The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus

Mráz, Miloš; Lacinová, Z; Drápalová, J.; Haluzíková, D; Hořı́nek, A.; Matoulek, Martin; Trachta, Pavel; Kaválková, Petra; Svačina, Š; Haluzı́k, Martin

doi:10.1210/jc.2010-1858

Cited by 64 publications

(54 citation statements)

References 29 publications

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“…Low-grade inflammation is a common feature in subjects with type 2 diabetes 6 as increased levels of circulating inflammatory markers were found to be significantly more prominent in type 2 diabetes 7 . Increased inflammatory markers in type 2 diabetes are believed to originate, at least partially, from adipose tissue 8,9 . Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) are two major pro-inflammatory cytokines, secreted in significant amounts from adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial

Gari²,

2014

Afr H. Sci.

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Background: Recently some plasma biomarkers of inflammation have been recognized as important cardiovascular risk factors. There is little information about the effects of aerobic exercise training on these biomarkers and the risk of metabolic complications in obese type 2 diabetes patients. Objective: To compare the impact of moderate versus mild aerobic exercise training on the inflammatory cytokines in obese type 2 diabetic patients. Methods: Fifty obese type 2 diabetic patients of both sexes with body mass index (BMI) varying from 31 to 36 kg/m 2 , non smokers, free from respiratory, kidney, liver, metabolic and neurological disorders, participated in this study. Their age ranged from 40 to 55 years. The subjects were included into two equal groups; the first group (A) received moderate aerobic exercise training. The second group (B) received mild aerobic exercise training, three times / week for 3 months. Results:The mean values of leptin, TNF-alpha, IL2, IL4, IL6, HOMA-IR and HBA1c were significantly decreased in group (A) and group (B). Also, there were significant differences between both groups after treatment. Conclusion: Moderate aerobic exercise training modulates inflammatory cytokines more than mild aerobic exercise training in obese type 2 diabetic patients.

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Section: Introductionmentioning

confidence: 99%

Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial

Gari²,

2014

Afr H. Sci.

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“…Mraz et al evidenced that a two-week VLCD regimen (~600 cal/day) decreased body weight and fasting glycemia accompanied by decreased C-reactive protein and IL-6 plasma levels in obese type 2 DM women. Moreover, these subjects experienced a reduction in inflammatory markers at the mRNA level, including chemokine receptors (e.g., CCR-1, CCR-2, CCR-5, IL-6 receptor) in peripheral monocytes and chemokines (CCL-8 and CXCL-10) in subcutaneous adipose tissue [8].…”

Section: Cytokines and Adipokines In Obesity And Type 2 Dmmentioning

confidence: 99%

“…VLCD appears to have the most profound and rapid positive effect on weight loss, insulin resistance, β-cell function, inflammation and OS than other calorie-restricted regimens [3,[46][47][48][49]. However, the majority of studies performed, thus far, have failed to demonstrate significant changes in adiponectin serum levels after VLCD regimens in obese and type 2 DM individuals, despite improvements on metabolism [6,8,50].…”

Section: Cytokines and Adipokines In Obesity And Type 2 Dmmentioning

confidence: 99%

“…Benefits of VLCD in T2DM patients with obesity include weight loss, fat mass reduction, reversion of hyperglycemia, elimination of pharmacologic treatment and normalization of both beta cell function and hepatic insulin sensitivity [3,5]. The main mechanism by which VLCD regimens exert their beneficial effects on metabolism of type 2 DM subjects appears to be their capacity to induce weight loss and modulate inflammation via cytokines and adipokines [6][7][8]. However, there are considerable limitations of VLCD regimens in certain individuals.…”

Section: Introductionmentioning

confidence: 99%

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Very Low-Calorie Diets in Type 2 Diabetes Mellitus: Effects on Inflammation, Clinical and Metabolic Parameters

Román-Pintos¹,

Villegas-Rivera²,

Cardona-Muñóz³

et al. 2018

Diabetes and Its Complications

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Type 2 diabetes mellitus (DM) is a chronic and multifactorial disease strongly linked to a low-grade inflammatory process. Thus far, type 2 DM is generally regarded as an incurable disease by common therapies. However, very low-calorie diet (VLCD) regimens have demonstrated beneficial and rapid effects on glucose metabolism in subjects with type 2 DM. These beneficial effects include improvement of diabetes complications, insulin sensitivity and reduction in glycaemia, glycated hemoglobin (HbA1C), and triglyceride levels. VLCD regimens commonly comprise no more than 800 kcal/day and are therefore associated with rapid weight loss in overweight and obese individuals. This group of diets positively affects local/systemic inflammation and oxidative stress (OS) by modulating inflammatory cytokines, adipokines and endogenous antioxidant levels. The investigation of VLCDs in the field of type 2 DM treatment is progressively augmenting due to the multiple benefits in cardiometabolic health of overweight/obese subjects with type 2 DM. Here, we gather and review the evidence regarding the role of inflammation and OS in individuals with type 2 DM under VLCD regimens.

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“…Systemic inflammation in type 2 diabetes is believed to originate, at least partially, from the adipose tissue [11][12][13][14] . The ability of pro-inflammatory cytokines (e.g., interleukin -6 (IL-6), tumor necrosis factor-alpha (TNF)-α) to act on the brain and to induce behavioral symptoms, including fatigue, is well documented in both experimental and clinical studies 15 .…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

2016

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Background: Non-insulin dependent diabetic patients frequently suffer from fatigue symptoms that result from chronic systemic inflammation. Aerobic exercise was proved to modulate systemic inflammation. Objective: This study was an attempt to measure the impact of aerobic exercises on fatigue symptoms related to systemic inflammation in obese patients with type 2 diabetes. Methods: Eighty obese patients with type 2 diabetes participated in the present study, their age ranged from 40-58 years and their BMI ranged from 31-36 kg/m 2 and were assigned to two subgroups; group (A) received aerobic exercise training for 12 weeks and group (B) received no exercise training for 3 months. Measurements of fatigue symptoms and markers of systemic inflammation were assessed before and at the end of the study for all participants in both groups. Results:The mean values of inflammatory markers (IL-6 and TNF-α) and Multidimensional Fatigue Inventory (MFI) was significantly decreased in group (A), while changes were not significant in group (B). Moreover, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study. Sci. 2015;15(4):1142-8. http://dx.doi.org/10.4314/ahs.v15i4.13 Conclusion

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The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus

Abstract: Obese patients with and without T2DM have increased mRNA expression of chemotactic and proinflammatory factors in SCAT and expression of corresponding receptors in PM. Two weeks of VLCD significantly improved this profile in T2DM patients.

Cited by 64 publications

References 29 publications

Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial

Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial

Very Low-Calorie Diets in Type 2 Diabetes Mellitus: Effects on Inflammation, Clinical and Metabolic Parameters

Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

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