Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

El-Kader, Shehab M Abd; Al-Jiffri, Osama H; Al-Shreef, Fadwa M

doi:10.4314/ahs.v15i4.13

Cited by 31 publications

(27 citation statements)

References 35 publications

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“…Similar research has never been conducted in China, sot no comparison may presently be made in the same population. Although the current study lacks without control groups of patients suffering from other diseases, the scores above are at a medium-high level with regard to related researches carried out among other clinical populations [ 53 – 56 ]. PSS had a significantly negative association with fatigue, accounting for almost half of the variance concerning its predicting role, indicating that less severity of fatigue might be experienced among RA patients when acquiring more positive assistance from others.…”

Section: Discussionmentioning

confidence: 92%

Associations of perceived social support and positive psychological resources with fatigue symptom in patients with rheumatoid arthritis

Zhao

Xue

et al. 2017

PLoS ONE

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ObjectiveThis study aimed to assess the association between perceived social support (PSS) and fatigue and the roles of hope, optimism, general self-efficacy and resilience as mediators or moderators on PSS-fatigue association among Rheumatoid Arthritis (RA) patients in China.MethodsA multi-center, cross-sectional study was conducted withinpatients diagnosed with RA in northeast China, in which 305 eligible inpatients were enrolled. The Multidimensional Fatigue Inventory, Multidimensional Scale of Perceived Social Support, Herth Hope Index, Life Orientation Test Revised, General Self-Efficacy Scale and Ego-Resiliency Scale were completed. The associations of PSS, hope, optimism, general self-efficacy and resilience with fatigue and the moderating roles of these positive psychological constructs were tested by hierarchical linear regression. Asymptotic and resampling strategies were utilized to assess the mediating roles of hope, optimism, general self-efficacy and resilience.ResultsThe mean score of the MFI was 57.88 (SD = 9.50). PSS, hope, optimism and resilience were negatively associated with RA-related fatigue, whereas DAS28-CRP was positively associated. Only resilience positively moderated the PSS-fatigue association (B = 0.03, β = 0.13, P<0.01). Hope, optimism and resilience may act as partial mediators in the association between PSS and fatigue symptoms (hope: a*b = -0.16, BCa 95%CI: -0.27, -0.03; optimism: a*b = -0.20, BCa 95%CI: -0.30, -0.10; resilience: a*b = -0.12, BCa 95%CI: -0.21–0.04).ConclusionsFatigue is a severe symptom among RA patients. Resilience may positively moderate the PSS-fatigue association. Hope, optimism and resilience may act as partial mediators in the association. PSS, hope, optimism and resilience may contribute as effective recourses to alleviate fatigue, upon which PSS probably has the greatest effect.

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Section: Discussionmentioning

confidence: 92%

Associations of perceived social support and positive psychological resources with fatigue symptom in patients with rheumatoid arthritis

Zhao

Xue

et al. 2017

PLoS ONE

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“…Thus, more research is needed to investigate fatigue and related factors among patients with T2D. Several programs have been shown to alleviate fatigue symptoms among patients with T2D, such as aerobic exercise, dietary intervention, and lifestyle intervention (Abd El-Kader et al, 2015; Brinkworth et al, 2016; Vadstrup et al, 2011). Nonetheless, few have reported the results on related health outcomes (e.g., A1C).…”

Section: Discussionmentioning

confidence: 99%

Fatigue in Adults with Type 2 Diabetes: A Systematic Review and Meta-analysis

Chen

Liu

2020

West J Nurs Res

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This review aimed to evaluate the level of fatigue in adults with type 2 diabetes measured by the validated Diabetes Symptom Checklist (DSC)and related factors. Ten studies were included. Both DSC (n = 4) and the revised (n = 6) have been used to measure fatigue. When the latter was used (n = 1082), the pooled level of fatigue was 1.77 (on a 0–5 scale). When the former was used (n = 674), the pooled level of fatigue was 1.73 (on a 0–10 scale). Participant demographics (e.g., gender), health information (e.g., BMI), and diabetes-specific factors (e.g., A1C and diabetes distress) were associated with fatigue. Fatigue was negatively related to self-care behaviors. The prevalence of significant fatigue remains unclear due to a lack of a cut-off point of the instrument. Future research is warranted to identify the threshold for clinically significant fatigue and investigate the causal relationship. Nurses are recommended to perform a routine assessment of fatigue.

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“…The interest of these studies is increasingly focused on determining the most adequate training to reduce the inflammatory state and its effects on metabolic syndrome in people with obesity. There is scientific evidence that aerobic training improves the levels of proinflammatory cytokines (TNF-α, IL-6, and IL-8) in people with obesity and type 2 diabetes [ 26 ]. In fact, aerobic or cardiorespiratory exercise programs are the most frequently implemented [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women

González-Jurado

Suárez-Carmona

López

et al. 2020

IJERPH

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Obesity is related to low-grade systemic inflammation. This state of inflammation is characterized by the alteration in adipokine regulation, which may lead to a situation of cardiometabolic risk. The aim of this study was to evaluate the effects of a concurrent training program on markers of lipoinflammation in adult people with obesity, comparing the response to the training between men and women. A quasi-experimental, quantitative, and longitudinal study with a pre–post intervention was conducted. An 8-week concurrent training program was carried out, in which 26 individuals with obesity participated (mean ± SD; age = 46.38 ± 4.66) (BMI = 36.05 ± 4.99) (12 men and 14 women). Before and after the intervention period, blood samples were taken by percutaneous puncture. The blood levels of adiponectin and leptin were evaluated. Significant differences were obtained in the adiponectin–leptin ratio (A/L ratio) of the entire sample (p = 0.009, ES = 0.53), which indicates a decrease in the risk of cardiovascular diseases and lipoinflammation. There were no significant differences in the improvements observed after the training in A/L ratio between women (A/L change = +63.5%) and men (A/L change= +59.2%). It can be concluded that the combination of aerobic exercise and resistance training induced an improvement in markers of lipoinflammation and cardiometabolic risk in the individuals with obesity evaluated in this study.

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Aerobic exercises alleviate symptoms of fatigue related to inflammatory cytokines in obese patients with type 2 diabetes.

Cited by 31 publications

References 35 publications

Associations of perceived social support and positive psychological resources with fatigue symptom in patients with rheumatoid arthritis

Associations of perceived social support and positive psychological resources with fatigue symptom in patients with rheumatoid arthritis

Fatigue in Adults with Type 2 Diabetes: A Systematic Review and Meta-analysis

Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women

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