The effect of reduced glomerular filtration rate on plasma total homocysteine concentration

Arnadottir, Margret; Hultberg, Björn; Nilsson‐Ehle, Peter; Thysell, Hans

doi:10.3109/00365519609088586

Cited by 223 publications

(150 citation statements)

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“…We also found an inverse relationship between plasma homocysteine and renal function, as measured by GFR, in agreement with previous studies. 30 This relationship is unlikely attributable to bladder dysfunction associated with SCI-specific bladder management. Several studies have shown that bladder management techniques do not significantly affect renal function in persons with SCI.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine and hypertension in persons with spinal cord injury

et al. 2005

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Study design: Cross-sectional analysis of a convenience sample of locally recruited participants, including both patients and volunteers. Objectives: To determine whether there is an association between plasma homocysteine and hypertension in persons with spinal cord injury (SCI). Setting: Spinal Cord Injury Service of the Veterans Affairs Palo Alto Medical Center (California, United States of America). Methods: The incidence of hypertension, dyslipidemia, insulin resistance, and the presence of metabolic syndrome were determined in 168 individuals with SCI (mean age 50.2712.8 years). Fasting lipids, insulin, glucose, plasma homocysteine, and anthropometric data was gathered for each subject. Results: Blood pressure values (Po0.001) and mean arterial pressure (Po0.05) increased with higher plasma homocysteine levels. Homocysteine values were also significantly greater among individuals with hypertension compared with those who were normotensive or prehypertensive (Po0.0001). There was an inverse relationship between plasma homocysteine levels and glomerular filtration rate and effective renal plasma flow (Po0.05). Conclusions: Plasma homocysteine levels are elevated in persons with SCI who have hypertension and inversely related to renal function, which suggests that renal dysfunction may be a link between homocysteine and hypertension in persons with SCI.

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Section: Discussionmentioning

confidence: 99%

Homocysteine and hypertension in persons with spinal cord injury

et al. 2005

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“…The decreased level with gestation may be either due to physiological response to the pregnancy, increase in estrogen, hemodilution from increased plasma volume or increased demand for methionine by both the mother and fetus. Studies involving patients with renal disease show an inverse correlation between homocysteine and glomerular filtration rate (GFR) [21]. The GFR increases on an average by 50%-70% above prepregnant levels as early as 5 weeks of gestation and remains elevated throughout pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid and Homocysteine as Predictors of Pre-eclampsia

Sangeeta¹,

Shaini²

2013

J Diabetes Metab

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Objective: To estimate the serum homocysteine and uric acid levels in normal and pre-eclamptic patients and to find out any correlation between these parameters and pre-eclampsia Study design and setting: Cross-sectional study; Dept. of Biochemistry in collaboration with Department of Obstetrics and Gynaecology, Regional Institute of Medical Sciences (RIMS); Imphal (Manipur), India.Methods: Data collected from 50 pre-eclamptic pregnant women and 25 normotensive pregnant women admitted in Antenatal ward, Department of Obstetrics and Gynaecology, RIMS Hospital. The blood samples were collected from these patients and analyzed for serum homocysteine and uric acid level. Results:The serum homocysteine and uric acid levels were found to be significantly higher in preeclamptic cases than in normal controls. Mean ± SD of uric acid and homocysteine levels were 8.82 ± 1.68 mg% and 10.32 ± 2.52 µmol/l respectively in the cases compared to 4.06 ± 0.96 mg% and 3.55 ± 1.25 µmol/l in the controls. A positive correlation was found between the serum uric acid level, homocysteine and blood pressure. Thus the study showed a strong association between increased uric acid, blood pressure and homocysteine levels.

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“…Although it was said that urinary homocysteine excretion was minimal 42 , hyperfiltrating diabetic subjects with supernormal glomerular filtration rates may have subnormal fasting tHcy levels 47 . Indeed, it should be stressed that glomerular filtration rate and cystatin C are independent determinants of tHcy, and they are much better determinants than is creatinine concentration 48,49 . Although there is a direct relationship between tHcy and KT/V (an index of dialysis adequacy), the dialytic amount of tHcy did not seem to contribute significantly to its removal 38 .…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocyst(e)inemia in chronic stable renal transplant patients

et al. 2000

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RHCFAP/3019 MACHADO DJ de B et al. -Hyperhomocyst(e) Purpose:Hyperhomocyst(e)inaemia is an important risk factor for atherosclerosis, which is currently a major cause of death in renal transplant patients. The aim of this study was to assess the influence of immunosuppressive therapy on homocyst(e)inemia in renal transplant recipients.Methods: Total serum homocysteine (by high performance liquid chromatography), creatinine, lipid profile, folic acid (by radioimmunoassay-RIA) and vitamin B12 (by RIA) concentrations were measured in 3 groups. Group I patients (n=20) were under treatment with cyclosporine, azathioprine, and prednisone; group II (n=9) were under treatment with azathioprine and prednisone; and group III (n=7) were composed of renal graft donors for groups I and II. Creatinine, estimated creatinine clearance, cyclosporine trough level, lipid profile, folic acid, and vitamin B12 concentrations and clinical characteristics of patients were assessed with the aim of ascertaining determinants of hyperhomocyst(e)inemia.Results: Patient ages were 48.8 ± 15.1 yr (group I), 43.3 ± 11.3 yr (group II); and 46.5 ± 14.8 yr (group III). Mean serum homocyst(e)ine (tHcy) concentrations were 18.07 ± 8.29 mmol/l in renal transplant recipients; 16.55 ± 5.6 mmol/l and 21.44 ± 12.1 mmol/l respectively for group I (with cyclosporine) and group II (without cyclosporine) (NS). In renal donors, tHcy was significantly lower (9.07 ± 3.06 mmol/l; group I + group II vs. group III, p<0.008). There was an unadjusted correlation (p<0.10) between age (r=0.427; p<0.005) body weight (r=0.412; p<0.05), serum creatinine (r=0.427; p<0.05), estimated creatinine clearance (r=0.316; p<0.10), and tHcy in renal recipients (group I +II). Independent regressors (r 2 =0.46) identified in the multiple regression model were age (coefficient= 0.253; p=0.009) and serum creatinine (coefficient=8.07; p=0.045). We found no cases of hyperhomocyst(e)inemia in the control group. In contrast, 38% of renal recipients had hyperhomocyst(e)inemia: 7 cases (35%) on cyclosporine and 4 (45%) without cyclosporine, based on serum normal levels.Conclusions: Renal transplant recipients frequently have hyperhomocyst(e)inemia. Hyperhomocyst(e)inemia in renal transplant patients is independent of the scheme of immunosuppression they are taking. The older the patients are and the higher are their serum creatinine levels, the more susceptible they are to hyperhomocyst(e)inemia following renal transplantation.

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The effect of reduced glomerular filtration rate on plasma total homocysteine concentration

Cited by 223 publications

References 10 publications

Homocysteine and hypertension in persons with spinal cord injury

Homocysteine and hypertension in persons with spinal cord injury

Serum Uric Acid and Homocysteine as Predictors of Pre-eclampsia

Hyperhomocyst(e)inemia in chronic stable renal transplant patients

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