Serum Uric Acid and Homocysteine as Predictors of Pre-eclampsia

Sangeeta, N; Shaini, L.

doi:10.4172/2155-6156.1000259

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…18 Almost similar findings were also observed in some other studies. [19][20][21] In the current study, it was observed that the mean serum homocysteine was 16.4±7.9 µmol/l in mild preeclampsia, 20.8±8.0 µmol/l in severe preeclampsia and 8.2±3.7 µmol/l in normal pregnant group.A study conducted by Yelikar and colleagues found the mean serum homocysteine levels in mild preeclampsia, severe preeclampsia was 14.99±3.47 µmol/l and 19.90±6.17 µmol/l and 12.48±2.95 µmol/l in normal pregnancy. 18 The study conducted by Ferdausi and colleagues found the mean serum homocysteine levels in mild preeclampsia, severe preeclampsia was 10.43±5.12 mol/l and 11.5±4.58 mol/l and 5.70±1.30 mol/L in normal pregnancy.…”

Section: Discussionsupporting

confidence: 53%

“…24 In this present study there is a significant positive correlation (r=0.455; p=0.001) was found between systolic blood pressure with serum homocysteine level.Othersimilar studies showed a positive correlation between serum homocysteine and systolic blood pressure. 16,19,25 . The above findings are closely resembled with the present study.In this present study significant positive correlation (r=0.546, p=0.001) was also found between diastolic blood pressure with serum homocysteine level, which is similar with some other studies.…”

Section: Discussionmentioning

confidence: 99%

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Association of Maternal Serum Homocysteine Levels with Pre-eclampsia

Rumi,

Zabin,

Hosain

et al. 2021

J Chittagong Med Coll Teachers Ass

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Background: Pre-eclampsia is a major cause of maternal or fetal morbidity and mortality. Its pathophysiology is still an area of dilemma. Homocysteine is a sulfur containing amino acid, which damages smooth muscle of the vessel wall. The objective of this study was to investigate the association of serum homocysteine levels with preeclampsia. Materials and methods: This case control study was carried out in the Department of Obstetrics & Gynecology Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from April 2017 to March 2018. The study reviewed a total of 108 women with pregnancy. These participants were categorized into three groups: healthy pregnant subjects group, mild preeclampsia group and severe preeclampsia group. The three study groups were statistically similar in aspects of maternal age, gestational age and parity. Results: The mean serum homocysteine level was found 16.4±7.9 μmol/l in mild preeclampsia group, 20.8±8.0 μmol/l in severe preeclampsia group and 8.2±3.7 μmol/l in the group of normal pregnant women. Serum homocysteine was significantly increased in severe preeclampsia and mild preeclampsia in comparison to normal group without preeclampsia. Significant positive correlation was found between systolic blood pressure (p=0.001) diastolic blood pressure (p=0.001) with serum homocysteine level. Conclusion: The study concluded that a significant positive association was found between pre-eclampsia and maternal serum homocysteine levels. This may provide informationonthe role of homocysteine in preeclampsia with a preventive strategy of consequences of this condition. JCMCTA 2021 ; 32 (1) : 14-20

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Association of Maternal Serum Homocysteine Levels with Pre-eclampsia

Rumi,

Zabin,

Hosain

et al. 2021

J Chittagong Med Coll Teachers Ass

View full text Add to dashboard Cite

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“…According to Sangeeta et al [19], the cause of hyperuricemia in preeclampsia is attributed to either a decreased excretion or to an increased production of uric acid.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of Applicability of Salivary Uric Acid Measurement in Preeclampsia and Normal Pregnancy and Its Correlation with Serum Uric Acid

Singh

Solanki

Mehrotra

et al. 2018

J Obstet Gynecol India

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Purpose Hypertensive disorders complicate 5-10% of all pregnancies and contribute greatly to maternal morbidity and mortality. There are various biomarkers for detection of preeclampsia. Several studies have reported that positive correlation exists between serum uric acid (UA) levels and adverse maternal and fetal outcome. Significant advances have been made toward validation of salivary biomarkers. We conducted this study to determine levels of salivary UA and its correlation with serum UA normal pregnancy and preeclampsia. Methods Present cross-sectional study was conducted in tertiary care teaching hospital in North India. One hundred and fifty participants were divided into control group (50 healthy non-pregnant females), study group I (50 normotensive pregnant females), study group II (50 pregnant females with preeclampsia), and both salivary and serum UA was estimated at the same time.Results Saliva UA of study group II (4.86 ± 2.37 mg/dl) was significantly higher (p \ 0.001) than that of control group (2.09 ± 1.33 mg/dl) and study group I

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Study of Serum Calcium, Magnesium, Uric Acid and Liver Enzymes in Pregnancy Induced Hypertension

Anusha¹,

Sankaranarayana²

2018

jemds

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BACKGROUND The lowering of serum calcium can cause an elevation of blood pressure in pre-eclamptic mothers. Magnesium is a potent vasodilator of uterine and mesenteric arteries and aorta. Magnesium also increases NO production causing vasodilation. Elevation of uric acid in preeclampsia is due to factors such as abnormal renal clearance, increased tissue breakdown, acidosis and a rise in the activity of the xanthine oxidase/ dehydrogenase enzyme. In preeclampsia hypervascularisation and vasoconstriction of liver leads to liver cell injury and alteration of cell membrane permeability and damage to the cells which allows intracellular enzymes to leak into the blood leading to elevated liver enzymes like AST, ALT and Alkaline phosphatase. Aims and Objectives of the Study-To estimate and compare the levels of serum calcium, magnesium, uric acid and liver enzymes in women with preeclampsia and normal pregnant women. MATERIALS AND METHODS This case control study was conducted at GGH, Vijayawada, Andhra Pradesh. Data was collected from 50 preeclampsia cases and 50 normal healthy pregnancies in the Department of Obstetrics and Gynaecology. RESULTS Mean Gestational age showed high significance with mean ± SD of cases at 36.38 ± 4.19 weeks compared to that of controls at 39.62 ± 1.16 weeks with a 'p' value of < 0.001. Systolic BP (150.4 ± 19.37 mmHg vs. 109.6 ± 7.55 mmHg) and mean ± SD of Diastolic BP (100.6 ± 14.05 mmHg vs. 75.4 ± 5.30 mmHg) of the pre-eclamptic group are significantly higher than the control group. Value of calcium in pre-eclamptic women was significantly low (8.57 ± 0.96 mg/dL vs. 9.88 ± 1.38 mg/dL; p < 0.001). Magnesium in preeclamptic women was lower than normal pregnant women (1.92 ± 0.36 mg/dL vs. 2.26 ± 0.25 mg/dL; p < 0.001). The serum uric acid in pre-eclamptic women was significantly more than normal pregnant women (6.66 ± 2.21 mg/dL vs. 4.51 ± 1.18 mg/dL, p < 0.001). ALP, AST and ALT were increased in cases compared to controls and are statistically highly significant (p < 0.001). CONCLUSION Based on the present study, serum calcium and magnesium levels are low in pre-eclamptic mothers. Pregnant women should be educated about nutrition during pregnancy and probable risks of inappropriate diet should be informed. Thus, it can be concluded that Calcium and Magnesium can be evaluated at an early date, so that such mineral deficiencies can be treated by appropriate Calcium and Magnesium supplements. Uric acid and Liver enzymes can possibly be used as biomarkers for identifying and avoiding adverse pregnancy outcomes by prompt intervention.

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Serum Uric Acid and Homocysteine as Predictors of Pre-eclampsia

Cited by 4 publications

References 16 publications

Association of Maternal Serum Homocysteine Levels with Pre-eclampsia

Association of Maternal Serum Homocysteine Levels with Pre-eclampsia

An Evaluation of Applicability of Salivary Uric Acid Measurement in Preeclampsia and Normal Pregnancy and Its Correlation with Serum Uric Acid

Study of Serum Calcium, Magnesium, Uric Acid and Liver Enzymes in Pregnancy Induced Hypertension

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