Hyperhomocysteinemia has been considered an independent risk factor in the development of stroke. The present study was undertaken to evaluate serum homocysteine levels in patients with cerebrovascular accidents among the Manipuri population and to compare with the normal cases. Ninety-three cerebrovascular accident cases admitted in the hospital were enrolled for the study and twenty-seven age and sex matched individuals free from cerebrovascular diseases were taken as control group. Serum homocysteine levels were estimated by ELISA method using Axis homocysteine EIA kit manufactured by Ranbaxy Diagnostic Ltd. India. The finding suggests that hyperhomocysteinemia is associated with cerebrovascular accident with male preponderance, which increases with advancing age. However, whether hyperhomocysteinemia is the cause or the result of cerebrovascular accidents needs further investigations.

Objective: To estimate the serum homocysteine and uric acid levels in normal and pre-eclamptic patients and to find out any correlation between these parameters and pre-eclampsia Study design and setting: Cross-sectional study; Dept. of Biochemistry in collaboration with Department of Obstetrics and Gynaecology, Regional Institute of Medical Sciences (RIMS); Imphal (Manipur), India.Methods: Data collected from 50 pre-eclamptic pregnant women and 25 normotensive pregnant women admitted in Antenatal ward, Department of Obstetrics and Gynaecology, RIMS Hospital. The blood samples were collected from these patients and analyzed for serum homocysteine and uric acid level. Results:The serum homocysteine and uric acid levels were found to be significantly higher in preeclamptic cases than in normal controls. Mean ± SD of uric acid and homocysteine levels were 8.82 ± 1.68 mg% and 10.32 ± 2.52 µmol/l respectively in the cases compared to 4.06 ± 0.96 mg% and 3.55 ± 1.25 µmol/l in the controls. A positive correlation was found between the serum uric acid level, homocysteine and blood pressure. Thus the study showed a strong association between increased uric acid, blood pressure and homocysteine levels.

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Aim: The aim of our study was to estimate the level of HbA1c in patients with Acute Coronary Syndrome (ACS). To determine any correlation between HbA1c, admission blood glucose (Random blood sugar), serum lipid profile among the cases and to evaluate the outcome during hospitalization. Study Design and Setting: Cohort study. Place and Duration of the Study: Department of Biochemistry and General Medicine including ICCU and Cardiology unit, RIMS, Imphal, between September 2015 to August 2017. Methodology: Data were collected from 98 patients admitted in Medicine ward who were diagnosed with ACS irrespective of their diabetes status and they were divided into three groups according to their HbA1c levels (<5.7%, 5.7-6.4%, > 6.5%). The blood samples collected by venipuncture were analyzed for HbA1c level, done by RANDOX HbA1c Rx series (latex agglutination inhibition assay), admission blood glucose (measured by Trinder’s method) and serum lipid profile (RANDOX enzymatic Endpoint Method Rx series). The data were analyzed using statistical tools like Chi Square test, Independent sample t test, Pearson’s Correlation, Fisher’s exact test through SPSS 21.0. Results: Majority of the patients were men (72.4%) & (27.6%) women and in the age group of 51-65 years. The mean age is 62.14 years. 54.1% of the ACS patients were already diagnosed cases of type 2 diabetes mellitus whereas 45.9% were non-diabetic. Out of 98 patients, 60 had HbA1c level in the diabetic range (≥6.5%), 25 in the pre-diabetic range (5.7-6.4%) and the remaining 13 were within normal range (<5.7%). Admission blood glucose, total cholesterol and LDL were positively correlated with HbA1c value. Conclusion: The mortality of the ACS patients irrespective of diabetic status during hospitalization was associated with HbA1c value irrespective of diabetic status during hospitalization. However, it was not associated with thirty days mortality.