Objective: To estimate the serum homocysteine and uric acid levels in normal and pre-eclamptic patients and to find out any correlation between these parameters and pre-eclampsia Study design and setting: Cross-sectional study; Dept. of Biochemistry in collaboration with Department of Obstetrics and Gynaecology, Regional Institute of Medical Sciences (RIMS); Imphal (Manipur), India.Methods: Data collected from 50 pre-eclamptic pregnant women and 25 normotensive pregnant women admitted in Antenatal ward, Department of Obstetrics and Gynaecology, RIMS Hospital. The blood samples were collected from these patients and analyzed for serum homocysteine and uric acid level. Results:The serum homocysteine and uric acid levels were found to be significantly higher in preeclamptic cases than in normal controls. Mean ± SD of uric acid and homocysteine levels were 8.82 ± 1.68 mg% and 10.32 ± 2.52 µmol/l respectively in the cases compared to 4.06 ± 0.96 mg% and 3.55 ± 1.25 µmol/l in the controls. A positive correlation was found between the serum uric acid level, homocysteine and blood pressure. Thus the study showed a strong association between increased uric acid, blood pressure and homocysteine levels.
Background: Thyroid hormone inuences glucose homeostasis by modications of the circulating insulin levels and peripheral tissues uptake of glucose. Thyroid function has been associated with insulin resistance. There is infrequent information about thyroid function in relation with glucose homeostasis in young adults. Objective: To evaluate the thyroid prole, fasting serum insulin, HOMA-IR, Fasting blood sugar among newly detected hypothyroid adults (cases) in comparison with normal healthy adults (controls). Methodology: A case control study of 164 subjects was carried out on hypothyroid adults (n=82) and controls (n=82), general medicine OPD, RRMC & hospital, Bengaluru. Fasting blood samples were taken. Thyroid prole, serum fasting insulin was done with CLIA. HOMA-IR was employed to assess the level of insulin resistance. Results: The study subjects with mean age of 35 years and female predominance. TSH levels were higher in cases as compared to controls (p<0.01). However, the value of both T3 and T4 levels were found to be lower in cases as compared to controls and the difference of T3 between the groups was statistically signicant (p=0.03) while that of T4 was not signicant (p=0.07). FT3 & FT4 levels were within the reference range. Serum fasting insulin levels and HOMA-IR levels were higher in cases than controls (p=0.007) and (p<0.01) respectively. A strong positive correlation was found between TSH and insulin (r=.528, p<.01), TSH and HOMA-IR (r=.462, p<.01), insulin and HOMA-IR (r=.962, p<.01). Conclusion: Our study shows that hypothyroidism is common among females and associated with mild degree of insulin resistance as reected by HOMA-IR.
Background: Elevated body iron stores have been implicated as a risk factor of coronary artery disease (CAD
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