The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial

Silva, S G L da; Terreri, Maria Teresa; Abad, Thais Tobaruela Ortiz; Machado, Daniele G.; Fonseca, Fernando; Hix, Sonia; Souza, Fabíola Isabel Suano de; Sarni, Roseli Saccardo; Len, Cláudio Arnaldo

doi:10.1177/0961203317751851

Cited by 15 publications

(21 citation statements)

References 29 publications

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“…Our group has previously reported a high prevalence of dyslipidemia in children and adolescents with JIA and jSLE. [6][7][8][9] It is well established in the literature that dyslipidemia is a relevant factor for triggering the atherosclerotic process. 1 To our knowledge, this is the first study conducted in the pediatric population that describes the prevalence of dyslipidemia in individuals with JDM.…”

Section: Resultsmentioning

confidence: 99%

Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis

Rodrigues

Sarni

Abad

et al. 2020

Rev. Assoc. Med. Bras.

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SUMMARY AIM To describe the prevalence of dyslipidemia in children and adolescents with autoimmune rheumatic diseases (ARDs), particularly juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (jSLE), and juvenile dermatomyositis (JDM). METHODS Retrospective cross-sectional study conducted in the pediatric rheumatology outpatient clinic. We evaluated 186 children and adolescents between the ages of 5 and 19 years. The medical records were reviewed for the following data: demographic and clinical features, disease activity, and lipid profile (triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C) and very low density lipoprotein (VLDL-C)). In addition, non-HDL cholesterol was calculated as TC minus HDL-C. The cut-off points proposed by the American Academy of Pediatrics were used to classify the lipid profile. RESULTS Dyslipidemia was observed in 128 patients (68.8%), the most common being decreased HDL-C (74 patients, 39.8%). In the JIA group there was an association between the systemic subtype and altered LDL-C and NHDL-C, which demonstrated a more atherogenic profile in this subtype (p=0.027 and p=0.017, respectively). Among patients with jSLE, the cumulative corticosteroid dose was associated with an increase in LDL-C (p=0.013) and with a decrease in HDL-C (p=0.022). CONCLUSION Dyslipidemia is common in children and adolescents with ARDs, especially JIA, jSLE, and JDM, and the main alteration in the lipid profile of these patients was decreased HDL-C.

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Section: Resultsmentioning

confidence: 99%

Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis

Rodrigues

Sarni

Abad

et al. 2020

Rev. Assoc. Med. Bras.

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“…Regarding the use of medication, in the studies by Davies et al [7] and Silva et al [11], there was no significant difference between the groups in terms of prednisolone dosage and hydroxychloroquine users. Shah et al [8] found that prednisolone use was slightly higher in the control group but without significant difference.…”

Section: Medication Used By Patientsmentioning

confidence: 89%

“…Silva et al [11]. included adolescents diagnosed with systemic lupus erythematosus for at least six months, with any clinical manifestation and disease activity.…”

Section: Sample Characteristicsmentioning

confidence: 99%

The impact of a low-calorie, low-glycemic diet on systemic lupus erythematosus: a systematic review

et al. 2021

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Background Diet plays a critical role in Systemic Lupus Erythematosus (SLE) patients, impacting on the microbiota composition and, consequently, on the immune response. The objective was to analyze and verify the diet effect on SLE patients. Methods This is a systematic review performed at the Evidences-based Health Lab, Escola Superior em Ciências da Saúde, Brasília (DF), Brazil. In March, 2021, five databases, and grey literature, through JSTOR, Open Grey, and Google Scholar were searched. Randomized Clinical Trials in which SLE patients with calorie restricted, low glycemic index or other diet involving the joint adequacy of these aspects, compared with placebo or different types of diet, were included. Results It was identified in the databases 758 articles; 132 were duplicated; 616 references were screened, and 604 were excluded. After reading the title and abstract, 12 articles were included for full-text reading. After the full-text reading, three studies were included for quantitative analysis. The diet improved the quality of life at 6 (MD 16.30; 5.91;26.69) and 12 weeks (MD 14.60; 0.88;28.32). The GRADE was used to evaluate the quality of evidence. Conclusion There is low evidence that the diet has a positive impact on the quality of life of SLE patients. Trial registration PROSPERO—CRD4202012208.

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“…Other patient groups responding well to treatment with statins, as assessed by HDL and LDL-C levels, have been shown to have high ApoB[47, 48]; thus apolipoprotein measures could help optimise the efficacy of lipid modifying therapy by targeting the correct patients. In addition to statins other interventions could also be relevant including PCSK9 inhibitor[49] and nutritional intervention through increased dietary intake of omega-3 FAs[50, 51]. The efficacy of personalised nutritional therapy has been validated recently in patients with diabetes; high variability between post-meal glucose levels in patients was used to stratify patients for specific short-term personalised dietary interventions to manage glucose levels[52].…”

Section: Discussionmentioning

confidence: 99%

“…The efficacy of personalised nutritional therapy has been validated recently in patients with diabetes; high variability between post-meal glucose levels in patients was used to stratify patients for specific short-term personalised dietary interventions to manage glucose levels[52]. Dietary intervention has been shown to reduce disease activity scores in SLE patients[50, 53] and patients are very engaged with such strategies[25].…”

Section: Discussionmentioning

confidence: 99%

Metabolomics in juvenile-onset SLE: identifying new biomarkers to predict cardiovascular risk

Robinson

Waddington

Coelewij

et al. 2019

Preprint

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BACKGROUND: Juvenile-onset systemic lupus erythematosus (JSLE) is an autoimmune disorder characterised by immune dysregulation, chronic inflammation and increased cardiovascular risk (CVR). Cardiovascular disease is the leading cause of mortality in JSLE patients not attributable to disease flares. However, it is not possible to predict those patients at greatest risk using traditional CVR factors. METHODSerum metabolomic analysis was performed using a nuclear magnetic resonance spectroscopy-platform in 31 JSLE patients. Data was analysed using cluster, linear regression and receiver operating characteristic analysis. Results were validated in a second cohort of 31 JSLE patients and using data from a cohort of adult-onset SLE patients with known pre-clinical atherosclerotic plaque. RESULTS: Unbiased hierarchical clustering of metabolomic data identified three patient groups. Group-1 had decreased atheroprotective high density lipoproteins (HDL) and increased atherogenic very low and low density lipoproteins (VLDL/LDL); Group-2 had elevated HDL but reduced VLDL/LDL; and Group-3 had low HDL/VLDL/LDL levels. Notably, apolipoprotein(Apo)B1:ApoA1 ratio, a known CVR marker in adult cohorts, was elevated in Group-1 JSLE patients compared to Groups-2/3. The metabolomic signature was validated in a second JSLE cohort and compared with lipid biomarkers previously associated with pre-clinical atherosclerotic plaque in adult SLE patients. Linear regression analysis accounting for demographics, treatment, disease activity, lupus serological markers and body mass index confirmed that a unique metabolomic profile could differentiate between JSLE patients at high and low CVR. CONCLUSIONS: Patient stratification using ApoB:ApoA1 ratio and lipoprotein signatures could facilitate tailored lipid modification therapies and/or diet/lifestyle interventions to combat increased CVR in JSLE.

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The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial

Cited by 15 publications

References 29 publications

Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis

Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis

The impact of a low-calorie, low-glycemic diet on systemic lupus erythematosus: a systematic review

Metabolomics in juvenile-onset SLE: identifying new biomarkers to predict cardiovascular risk

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