Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis

Rodrigues, Wellington Douglas Rocha; Sarni, Roseli Oselka Saccardo; Abad, Thais Tobaruela Ortiz; Silva, Simone Guerra Lopes da; Souza, Fabíola Isabel Suano de; Len, Cláudio Arnaldo; Terreri, Maria Teresa

doi:10.1590/1806-9282.66.8.1093

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…The present study showed that dyslipidemia affected more than three-quarters of JIA patients, with the predominance of borderline-low HDL-c based on classical lipid profile. Similar results were found in a retrospective study published by our research group [23]. We observed a higher frequency of increased LDL-c, NHDL-c, and Apo B in the systemic subtype than the polyarticular subtype.…”

Section: Discussionsupporting

confidence: 92%

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity

et al. 2021

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Background To describe the biomarkers of lipid metabolism in children and adolescents with polyarticular and systemic JIA and to relate them to diseases subtypes, diseases activity markers, and nutritional status. Methods A cross-sectional study including 62 JIA patients was performed. The following variables were evaluated: disease activity and medications used, body mass index, height for age (z-score), skin folds (bicipital, tricipital, subscapular and suprailiac), food intake based on three 24-h food recalls, lipid profile (total cholesterol (CT), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG) and non-HDL (N-HDLc), glycemia and insulin, erythrocyte sedimentation rate (ESR), ultrasensitive C-reactive protein (us-CRP) and apolipoproteins A-I and B (Apo A-I and Apo B). Results Dyslipidemia was observed in 83.3% of the patients. Based on classical lipid profile, low HDL-c levels was the most frequently alteration observed. Inadequate levels of LDL-c, Apo B and NHDL-c were significantly more frequent in the systemic JIA subtype when compared to the polyarticular subtype (p = 0.017, 0.001 and 0.042 respectively). Patients on biological therapy had a better adequacy of Apo A-I concentrations. The ESR showed a negative correlation with Apo A-I level (r = − 0.25, p = 0.047). Conclusion We concluded that dyslipidemia is common in patients with JIA, especially in systemic subtype. The systemic subtype and an elevated ESR were associated with lower concentrations of Apo A-I, suggesting the participation of the inflammatory process.

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Section: Discussionsupporting

confidence: 92%

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity

et al. 2021

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“…A retrospective cross-sectional study of 2020 by Rodrigues et al. ( 52 ), aimed to describe the prevalence of dyslipidemia in children and adolescents with autoimmune diseases (ARDs), such as JSLE. They studied 186 children and adolescents between the ages of 5 and 19 years old and found dyslipidemia in 128 patients (68.8%), the most common being low HDL-C (74 patients, 39.8%).…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular risk and inflammation in a population with autoimmune diseases: a narrative review

Bertoni,

Mazzocchi,

Leone

et al. 2024

Front. Immunol.

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Juvenile Systemic Connective Tissue Diseases (JSCTD) are a heterogeneous group of chronic autoimmune diseases, associated with dyslipidemia and increased cardiovascular risk are related. Studies from the last 10 years, from 2013 to 2022, on lipid profiles in JSCTD were collected. Different studies on lipid profiles in children affected by JSCTD were selected, because the aim is to analyze the cardiovascular risk and the possibility of atherosclerosis in these patients in whom, sometimes, corticosteroid therapies and immunosuppressants increase the state of dyslipidemia. Several studies have shown that autoimmune diseases with an inflammatory substrate also share abnormalities in lipid profile and increased cardiovascular risk. Specifically, associations have been found between Juvenile Systemic Connective Tissue Diseases and elevated triglycerides, TC-C (Total Cholesterol), LDL-C (Low-Density Lipoprotein), low HDL-C (High-Density Lipoprotein), and increased risk of developing diseases such as myocardial infarction, peripheral vascular disease, pulmonary and arterial hypertension, and atrial fibrillation. Supplementation with alpha-linolenic acid (ALA) on the other hand has also been analyzed with positive results in reducing inflammatory parameters, such as IL-6 (Interleukin-6), CRP (C-reactive protein), and fasting glucose, in subjects with dyslipidemia. These observations suggest that supplementation with ALA, an omega-3 precursor, may positively modulate both the inflammatory status and dyslipidemic conditions in patients with autoimmune disorders.

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“…An examination of blood lipids showed that children with SLE had obvious lipid metabolism disorders in the early stage, and they could be divided into the following types: increased serum TC level, increased serum TG level, increased serum LDL level, and decreased serum HDL level [ 15 ]. Some cross-sectional analytical studies found dyslipidemia rates of about 50%–85% in children with SLE [ 16 , 17 ]; however, no epidemiological studies have examined the blood lipid levels in children with LN. The incidence of dyslipidemia in children with LN in the current study was 89.2%, which was significantly higher than that in children without LN.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children

Song

Cui

2022

International Journal of Clinical Practice

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Objective. Systemic lupus erythematosus (SLE) is a relatively common rheumatic disease in children. The characteristics of blood lipid metabolism in children with LN are little reported. This study aimed to explore the relationship between blood lipid profiles and the risk of lupus nephritis (LN) in children. Methods. A total of 134 children with newly diagnosed SLE were divided into LN and non-LN groups according to pathological renal biopsy results. Clinical manifestations and blood lipid profiles were analyzed and compared between the two groups, and the relationships between blood lipid profiles and risk of LN were evaluated. Results. The positivity rate of an anti-dsDNA antibody and an SLE disease activity index (SLEDAI) were significantly increased, and C3 and C4 levels were significantly reduced in the LN compared with the non-LN group. The overall incidence of dyslipidemia was 79.9%, with a significantly high incidence in the LN group compared with the non-LN group. Total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and very LDLC (VLDL-C) were all higher in the LN group than those in the non-LN group. However, there was no significant difference in high-density lipoprotein cholesterol (HDL-C) between the two groups. The blood lipid levels were positively correlated with 24-hour urine protein quantification, urea, creatinine, uric acid, urinary IgG, urinary microalbumin, urinary transferrin, urinary α1 microglobulin, and urinary N-acetyl glucosidase, respectively. Receiver-operating characteristic curves showed that combined detection of TC, TG, LDL-C, and VLDL-C had higher discrimination capacity than that in individual measures. Additionally, increased TC was independently associated with the occurrence of LN. Conclusions. Children with LN have significant dyslipidemia. High levels of TC, TG, LDL-C, and VLDL-C are closely related to the occurrence of pLN. Clinical attention should be paid to monitoring and managing blood lipid profiles in children with LN.

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Lipid profile of pediatric patients with chronic rheumatic diseases - a retrospective analysis

Cited by 5 publications

References 21 publications

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity

Biomarkers of lipid metabolism in patients with juvenile idiopathic arthritis: relationship with disease subtype and inflammatory activity

Cardiovascular risk and inflammation in a population with autoimmune diseases: a narrative review

Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children

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