The effect of maternal anemia and iron deficiency on fetal erythropoiesis: comparison between serum erythropoietin, hemoglobin and ferritin levels in mothers and newborns

Erdem, A.; Erdem, Mehmet; Arslan, MI; Yazıcı, Gülce Naz; Eskandari, Ramin; Himmetoğlu, Özdemir

doi:10.1080/jmf.11.5.329.332

Cited by 36 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to the findings of this study, other studies conducted both within and outside Africa have found negative or no significant associations between maternal and infant anemia status [27,32,40,41]. Erdem et al ., [41] observed from their study in Turkey that cord hemoglobin and mean corpuscular volumes were not affected by maternal anemia status. According to them, high serum erythropoietin levels were associated with low maternal hemoglobin levels and suggested that maternal anemia rather induces fetal erythropoiesis.…”

Section: Discussioncontrasting

confidence: 99%

Predictors of fetal anemia and cord blood malaria parasitemia among newborns of HIV-positive mothers

et al. 2013

View full text Add to dashboard Cite

BackgroundMalaria and HIV infections during pregnancy can individually or jointly unleash or confound pregnancy outcomes. Two of the probable outcomes are fetal anemia and cord blood malaria parasitemia. We determined clinical and demographic factors associated with fetal anemia and cord blood malaria parasitemia in newborns of HIV-positive women from two districts in Ghana.ResultsWe enrolled 1,154 antenatal attendees (443 HIV-positive and 711 HIV-negative) of which 66% were prospectively followed up at delivery. Maternal malaria parasitemia, and anemia rates among HIV+ participants at enrolment were 20.3% and 78.7% respectively, and 12.8% and 51.6% among HIV- participants. Multivariate linear and logistic regression models were used to study associations. Prevalence of fetal anemia (cord hemoglobin level < 12.5 g/dL) and cord parasitemia (presence of P. falciparum in cord blood at delivery) were 57.3% and 24.4% respectively. Factors found to be associated with fetal anemia were maternal malaria parasitemia and maternal anemia. Infant cord hemoglobin status at delivery was positively and significantly associated with maternal hemoglobin and gestational age whilst female gender of infant was negatively associated with cord hemoglobin status. Maternal malaria parasitemia status at recruitment and female gender of infant were positively associated with infant cord malaria parasitemia status.ConclusionsOur data show that newborns of women infected with HIV and/or malaria are at increased risk of anemia and also cord blood malaria parasitemia. Prevention of malaria infection during pregnancy may reduce the incidence of both adverse perinatal outcomes.

show abstract

Section: Discussioncontrasting

confidence: 99%

Predictors of fetal anemia and cord blood malaria parasitemia among newborns of HIV-positive mothers

et al. 2013

View full text Add to dashboard Cite

show abstract

“…[5][6][7][8][9][10][11] However, some investigators could not find any relationship between maternal and fetal iron nutriture, thereby concluding that the fetus continues to extract iron efficiently from the mother regardless of her iron balance. [12][13][14][15][16][17] However, these studies did not include a sufficient number of pregnant women with severe anemia. Moreover, these studies also did not examine the effect of simultaneously occurring maternal malnutrition on fetal iron status.…”

Section: Discussionmentioning

confidence: 99%

Cord Blood and Breast Milk Iron Status in Maternal Anemia

Kumar¹,

Kumar²,

Basu³

et al. 2008

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Although serum ferritin levels are elevated in the fetus compared with the mother, the fetal iron stores correlate well with the iron stores of the mother (Milman et al 1987). In anemic mothers with iron deficiency, the fetal ferritin levels remain 10 times higher than the maternal ferritin at the time of delivery (Erdem et al 2002). At birth, the fetal red cell mass is ~50 mL/kg (Phillips et al 1986), compared with 25 – 30 mL/kg in adults (Fairbanks et al 1996).…”

Section: Major Causes Of Iron Deficiency Anemiamentioning

confidence: 99%

Iron Deficiency Anemia: A Common and Curable Disease

Miller

2013

Cold Spring Harbor Perspectives in Medicine

438

309

View full text Add to dashboard Cite

Iron deficiency anemia arises when the balance of iron intake, iron stores, and the body’s loss of iron are insufficient to fully support production of erythrocytes. Iron deficiency anemia rarely causes death, but the impact on human health is significant. In the developed world, this disease is easily identified and treated, but frequently overlooked by physicians. In contrast, it is a health problem that affects major portions of the population in underdeveloped countries. Overall, the prevention and successful treatment for iron deficiency anemia remains woefully insufficient worldwide, especially among underprivileged women and children. Here, clinical and laboratory features of the disease are discussed, and then focus is placed on relevant economic, environmental, infectious, and genetic factors that converge among global populations.

show abstract

The effect of maternal anemia and iron deficiency on fetal erythropoiesis: comparison between serum erythropoietin, hemoglobin and ferritin levels in mothers and newborns

Abstract: Although cord hemoglobin and mean corpuscular volume were not affected by maternal anemia, increased cord serum erythropoietin levels related to low maternal hemoglobin levels suggest an induced fetal erythropoiesis in maternal anemia.

Cited by 36 publications

References 9 publications

Predictors of fetal anemia and cord blood malaria parasitemia among newborns of HIV-positive mothers

Predictors of fetal anemia and cord blood malaria parasitemia among newborns of HIV-positive mothers

Cord Blood and Breast Milk Iron Status in Maternal Anemia

Iron Deficiency Anemia: A Common and Curable Disease

Contact Info

Product

Resources

About