Cord Blood and Breast Milk Iron Status in Maternal Anemia

Kumar, Ashok; Kumar, Arun; Basu, Sriparna; Dash, Debabrata; Singh, Jaiveer

doi:10.1542/peds.2007-1986

Cited by 95 publications

(86 citation statements)

References 36 publications

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“…In the present study, cord blood Hb and ferritin concentrations were not different between the 2 supplemented groups, while maternal ferritin levels were lower in the twice weekly group, confirming the efficiency of twice weekly iron consumption in preventing fetal anaemia and iron deficiency in the absence of maternal hypoferritinaemia. This is consistent with other studies which showed that even with mild maternal anaemia, the fetal haematological condition remains normal [21]. Higher levels of ferritin in cord blood can be attributed to active transport of iron to the fetus.…”

Section: Discussionsupporting

confidence: 92%

Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial

Goshtasebi

Alizadeh²

2012

East Mediterr Health J

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A randomized clinical trial examined the efficiency and tolerability of twice weekly versus daily iron supplementation during pregnancy. A total of 370 pregnant women were randomly assigned to receive either daily or twice weekly iron supplementation during pregnancy. There were no significant differences in initial and delivery haemoglobin and haematocrit levels between the 2 groups. Ferritin concentrations were significantly lower in the twice weekly group at delivery, but hypoferritinaemia (ferritin < 15 µg/L) was not observed in either group. The frequency of nausea, vomiting and constipation were significantly lower in the twice weekly group. Birth weight and length were significantly higher in the daily supplemented group. In non-anaemic mothers, a smaller dose of iron may be sufficient and also might prevent the complications of iron excess.

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Section: Discussionsupporting

confidence: 92%

Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial

Goshtasebi

Alizadeh²

2012

East Mediterr Health J

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“…9,10 However, low maternal prenatal iron levels measured as serum ferritin have not been consistently linked with low cord blood serum ferritin (CBSF) concentrations. 11,12 Despite the known detrimental consequences of early ID on cognition, studies on the impact of prenatal ID on neurocognitive outcomes in human subjects remain scanty. Hence, we set out to investigate the impact of ID at 3 periods of pregnancy and in early postnatal stages of infant development on the cognitive development of 1-year-old children.…”

Section: What This Study Addsmentioning

confidence: 99%

Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

et al. 2016

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To investigate the impact of prenatal maternal iron deficiency (ID) on cord blood serum ferritin (CBSF) concentration and infant cognitive and motor development. METHODS:Our prospective cohort study included 636 mother-singleton child pairs from 828 eligible pregnant women who were enrolled during their first antenatal care (ANC) visit in Allada, Benin, into a clinical trial comparing the efficacy of mefloquine and sulfadoxinepyrimethamine. Venous blood samples of women were assessed for ferritin and hemoglobin concentrations at the first and second ANC visits (occurring at least 1-month apart) and at delivery. Women were prescribed daily iron and folic acid supplements throughout pregnancy. Hematologic examinations were repeated for cord blood at birth. At age 1 year, cognitive and motor functions of children were assessed by using the Mullen Scales of Early Learning. RESULTS:The prevalence of prenatal ID at first and second ANC visits, and at delivery was 30.5%, 34.0%, and 28.4%, respectively. CBSF concentrations were similar between ID and non-ID pregnant women. Neither prenatal ID nor CBSF concentration was associated with poor cognitive or gross motor function of children at age 1 year. CBSF concentrations were lower among mothers who had ID anemia (IDA) at delivery compared with non-IDA pregnant women (adjusted mean difference: -0.2 [95% confidence interval: -0.4 to -0.0]). CONCLUSIONS:In a malaria-endemic region, ID in pregnancy in the context of iron supplementation is neither associated with CBSF concentration nor with infant cognitive and motor development. Prenatal IDA around the time of delivery is associated with lower CBSF concentrations.

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“…In contrast, Ahmad et al (20) observed that chord blood Hb was markedly higher in babies born to non-anemic mothers compared to the babies born to anemic mothers. In similar studies, maternal ferritin levels were shown to be in accordance with chord blood ferritin levels of the babies (21,22). However, studies have shown that inadequate iron status during pregnancy does not cause inhibition of transfer of iron to the baby, if the mother's nutrition is adequate (23).…”

Section: Discussionmentioning

confidence: 61%

Doğu Anadolu bölgesinde gebelerde ve doğan bebeklerinde demir durumu ve süt çocuklarında demir desteği gerekliliği

Poyrazoğlu¹,

Aygün²,

Üstündağ³

et al. 2011

tpa

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Cord Blood and Breast Milk Iron Status in Maternal Anemia

Abstract: Maternal anemia, particularly the severe type, adversely affects cord blood and breast milk iron status. Maternal nutritional status exerts a significant influence on fetal iron status but has little influence on breast milk iron content.

Cited by 95 publications

References 36 publications

Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial

Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial

Prenatal Iron Deficiency, Neonatal Ferritin, and Infant Cognitive Function

Doğu Anadolu bölgesinde gebelerde ve doğan bebeklerinde demir durumu ve süt çocuklarında demir desteği gerekliliği

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