Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial

Goshtasebi, Azita; Alizadeh, Mozhgan

doi:10.26719/2012.18.6.561

Cited by 5 publications

(3 citation statements)

References 21 publications

(33 reference statements)

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“…The weekly iron supplementation has been proven to be of high efficacy by some authors, including Goshtasebi and Alizadeh ( 15 ) and Shankar et al ( 16 ), in randomized controlled trials inclusive of the fortification of iron in foods such as wheat or cow milk. All tested approaches focused on improving the adherence to iron supplementation among pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Uptake of Iron Supplement During Pregnancy Among Women of Reproductive Age in Tanzania: an Analysis of Data From the 2015 to 2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey

Moshi

Millanzi

Mwampagatwa

2021

Front. Public Health

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Background: Pregnant women are vulnerable to iron deficiency due to the fact that more iron is needed primarily to supply the growing fetus and placenta and to increase the maternal red cell mass. Little is known on the factors associated with uptake of iron supplement during pregnancy.Methods: The study used data from the 2015 to 2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey. A total of 6,924 women of active reproductive age from 15 to 49 were included in the analysis. Both univariate and multiple regression analyses were used to determine factors associated with uptake of iron supplement during pregnancy.Results: Majority of the interviewed women 5,648 (81.6%) always took iron supplement during pregnancy, while a total of 1,276 (18.4%) women never took iron supplement during pregnancy. After controlling for confounders, the predictors for uptake of iron supplement during pregnancy were early antenatal booking (adjusted odds ratio, AOR = 1.603 at 95% CI = 1.362–1.887, p < 0.001); rural residence (AOR = 0.711 at 95% CI = 0.159–0.526, p = 0.007); wealth index [rich (AOR = 1.188 at 95% CI = 0.986–1.432, p = 0.07)]—poor was the reference population; level of education [primary education (AOR = 1.187 at 95% CI = 1.013–1.391, p = 0.034)]—no formal education was the reference population; parity [para 2 to 4 (AOR = 0.807 at 95% CI = 0.668–0.974, p = 0.026), para 5 and above (AOR = 0.75 at 95% CI = 0.592–0.95, p = 0.017)], para 1 was the reference population; zones [mainland rural (AOR = 0.593 at 95% CI = 0.389–0.905, p = 0.015) and Unguja Island AOR = 0.63 at 95% CI = 0.431–0.92, p = 0.017]—mainland urban was the reference population; and current working status [working (AOR = 0.807 at 95% CI = 0.687–0.949, p = 0.009)].Conclusion: The study revealed that, despite free access to iron supplement during pregnancy, there are women who fail to access the supplement at least once throughout the pregnancy. The likelihood to fail to access iron supplement during pregnancy was common among pregnant women who initiated antenatal visits late, were from poor families, had no formal education, reside in rural settings, had high parity, were from mainland rural, and were in working status. Interventional studies are recommended in order to come up with effective strategies to increase the uptake of iron supplement during pregnancy.

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Section: Introductionmentioning

confidence: 99%

Factors Associated With Uptake of Iron Supplement During Pregnancy Among Women of Reproductive Age in Tanzania: an Analysis of Data From the 2015 to 2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey

Moshi

Millanzi

Mwampagatwa

2021

Front. Public Health

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“…The haemoglobin levels is comparable to previous studies. 9,12,14 When the serum feeitin levels are compare between group A and group B, the difference at baseline is find to be statistically insignificant (p>0.05) whereas the difference in serum ferritin levels after 3 months oral iron supplementation is find to be statistically highly significant (p<0.05). Increase in serum ferritin is a reflection of increase of increase in storage iron.…”

Section: Resultsmentioning

confidence: 99%

Effect of Daily versus Supervised Weekly Single Dose Oral Iron in Pregnant Women: Hematological Outcome

Saxena¹

2017

JMSCR

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“…17 Goshtasebi et al concluded that daily or weekly iron supplementation has the similar effect. 18,15 Bouzari et al observed that there were no significant differences in the concentrations of hemoglobin and serum ferritin in nonanemic pregnant women who consume iron three times a week, once a week, or every day. 19 A recent study in India showed that weekly iron intake was considered effective in preventing anemia in nonanemic pregnant women, however it was less effective in anemic pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Side Effects of Daily versus Weekly Iron Supplementation in Pregnant Women

2019

J Bah Med Soc

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Background & Objective: Iron supplementation in pregnant women is highly recommended, however there is reduced compliance due to the common gastrointestinal side effects. This study aimed to compare the clinical side effects between pregnant women with daily and weekly iron supplementation. Methods: Seventy-nine pregnant women who met the inclusion and exclusion criteria were given iron supplements every day (group 1, n=37) and twice a week (group 2, n=42). All numerical data were assessed by independent t-test. Side effects were assessed after one month of administration using a questionnaire containing complaints felt by pregnant women and were evaluated by chi-square test using SPSS 25. A P value <0.05 was considered as statistically significant. Results: The most common side effects of iron supplementation in both groups were black feces (35.4%) and nausea (31.6%). Nausea (45.9% vs. 19.0%; P<0.05) and constipation (35.1% vs. 11.9%; P<0.05) were more frequent in group 1 than in group 2, respectively. Other side effects, such as heartburn, flatulence, vomiting, black feces, and urine discoloration did not differ significantly between the two groups (P>0.05). Conclusion: The daily iron supplementation elevated the episodes of nausea and constipation during pregnancy than the weekly supplementation. The daily iron supplementation in pregnant women increases the risk of side effects, potentially reducing compliance.

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Impact of twice weekly versus daily iron supplementation during pregnancy on maternal and fetal haematological indices: a randomized clinical trial

Cited by 5 publications

References 21 publications

Factors Associated With Uptake of Iron Supplement During Pregnancy Among Women of Reproductive Age in Tanzania: an Analysis of Data From the 2015 to 2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey

Factors Associated With Uptake of Iron Supplement During Pregnancy Among Women of Reproductive Age in Tanzania: an Analysis of Data From the 2015 to 2016 Tanzania Demographic and Health Survey and Malaria Indicators Survey

Effect of Daily versus Supervised Weekly Single Dose Oral Iron in Pregnant Women: Hematological Outcome

Side Effects of Daily versus Weekly Iron Supplementation in Pregnant Women

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