The effect of Kawasaki disease on childhood allergies – a sibling control study

Liew, Woei Kang; Lim, Chi Wan; Tan, Teng Hong; Wong, Keng Yean; Tai, Bee Choo; Quek, Swee Chye; Bever, Hugo Van

doi:10.1111/j.1399-3038.2011.01149.x

Cited by 34 publications

(34 citation statements)

References 24 publications

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“…Prevalence of atopic dermatitis, asthma and allergic rhinitis were reported to be higher in KD-affected children from a population-based study in Taiwan [13]–[15]. The related data suggests that children with history of KD were at a higher potential of developing allergic diseases.…”

Section: Introductionmentioning

confidence: 88%

IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease

Tseng

Guo

et al. 2014

PLoS ONE

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BackgroundKawasaki disease (KD) is known to be associated with T help (Th) 2 reaction and subsequently allergic diseases. Interleukin-31 (IL-31) has also been reported to be involved in Th2 mediated diseases such as allergic diseases. However, the role of IL-31 in KD has not been previously reported. The aim of this study is to investigate whether IL-31 is associated with KD and its clinical outcome.MaterialA total of 78 KD patients who met the criteria of KD were enrolled in this study as well as 20 age-matched controls. Plasma samples were conducted to measure IL-31 before intravenous immunoglobulin (IVIG) treatment (KD1), within 3 days after IVIG treatment (KD2) and at least 3 weeks after IVIG treatment (KD3) by utilizing enzyme-linked immunosorbent assay (ELISA).ResultOur findings showed that IL-31 expression was higher in KD patients after IVIG treatment significantly (KD2>KD1: 1265.0±199.3 vs. 840.2±152.5 pg/ml, p<0.0001). Further analysis revealed that IL-31 level was significantly higher in KD patients with coronary artery lesion (CAL) (656.6±139.5 vs. 1373.0±422.0 pg/ml, p = 0.04) before IVIG treatment (KD1). There were no significant differences between the IVIG resistance and IVIG responsiveness groups.ConclusionIL-31 was increased after IVIG treatment in patients with KD and was significantly associated with CAL formation. The results from this study may help to identify a novel risk factor for predicting KD and CAL formation.

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Section: Introductionmentioning

confidence: 88%

IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease

Tseng

Guo

et al. 2014

PLoS ONE

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“…In a sibling control study, Liew et al [15] hypothesized that children who had KD have a lower risk of developing allergic diseases. Because, KD is a multisystem inflammatory vasculitis of childhood with extensive Th1 type immune activation.…”

Section: Kawasaki Disease (Kd)mentioning

confidence: 99%

“…Interestingly, children in whom KD caused no coronary artery abnormalities have also more AR (OR: 8.50; 95% CI, 2.02-75.85). The authors assumed that KD happens more frequently in children at risk of immune disequilibrium, with an abnormal inflammatory response in the beginning, and consequently more allergic manifestations [15][16][17].…”

Section: Kawasaki Disease (Kd)mentioning

confidence: 99%

Correlation Between Prevalence of Allergic Rhinitis and Certain Diseases

Özdemir¹

2015

MOJI

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Allergic rhinitis is the most common chronic inflammatory disease of the upper respiratory tract, and its symptoms include watery rhinorrhea, sneezing, itching and nasal congestion. There have been quite different results for the prevalence of allergic diseases in different parts of world detected by surveys. However more amazingly, the international patterns of allergic disease prevalence cannot be explained by the current perception of the etiology of these conditions. Differences have been usually thought to be due to genetics, hygiene, diet, and environmental factors and not to be related to simply increased awareness of the disease. When current literature searched in detail, some of well-known specific diseases seem to be risk factors affecting development of allergic rhinitis. In this mini review, our aim is try to explain whether any relation between increasing allergic rhinitis prevalence and some specific disorders under the light of recent literature.

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“…Reports from East Asia have found a higher prevalence of atopic dermatitis, allergic rhinitis and asthma among children diagnosed with KD compared to the normal population [12,13,14,15,16]. However, to the best of our knowledge, large-scale studies regarding the incidence of allergic diseases occurring in KD patients are still lacking, especially regarding non-Asian populations.…”

Section: Introductionmentioning

confidence: 99%

Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers

Hassidim

Merdler²,

Chorin

et al. 2016

Int Arch Allergy Immunol

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Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. The purpose of this article was to achieve this goal. Methods: We conducted a cross-sectional, large-scale study to estimate the correlation of KD with allergic diseases. The medical history of 1,187,757 Israeli teenagers (aged 16-20 years during the years 1998-2013) was retrieved. The study population was divided into 3 groups according to a past history of noncomplicated and complicated KD and a control group. The prevalence of allergic diseases among these groups was further investigated. Results: The prevalence of atopic diseases in the 3 study groups was presented (asthma in 11.4, 8.1 and 3.5%, respectively; angioedema/urticaria in 7.1, 0 and 0.46%, respectively; allergic rhinitis in 20, 12.1 and 6.7%, respectively). In noncomplicated KD, a statistically significant link to asthma [odds ratio (OR) 2.4; p = 0.048] and a borderline significant link to allergic rhinitis (OR 1.9; p = 0.06) were found. In KD complicated with cardiac disease, statistically significant links were found for all the allergic conditions, asthma (OR 3.5; p = 0.003), allergic rhinitis (OR 3.5; p < 0.001) and angioedema/urticaria (OR 16.48; p < 0.001). Conclusion: KD is associated with allergic diseases. This association increases with the severity of the disease.

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The effect of Kawasaki disease on childhood allergies – a sibling control study

Abstract: Kawasaki disease may be a risk factor for subsequent allergic diseases. We postulate that KD occurs more frequently in children at risk of immune disequilibrium, with an abnormal inflammatory response initially, and subsequently more allergic manifestations.

Cited by 34 publications

References 24 publications

IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease

IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease

Correlation Between Prevalence of Allergic Rhinitis and Certain Diseases

Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers

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