IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease

Tseng, W.-N.; Lo, Mao Hung; Guo, Mindy Ming‐Huey; Hsieh, Kai‐Sheng; Chang, Wei Chiao; Kuo, Ho‐Chang

doi:10.1371/journal.pone.0105195

Cited by 18 publications

(9 citation statements)

References 30 publications

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“…reported that histological findings in KD including vasculitis, endothelial necrosis, and infiltration of mononuclear cells into blood vessels [ 57 ]. In previous studies, plasma levels of inflammatory cytokines (TNF-α, IL-4, IL-5, IL-6, IL-17, IL-31, and IP-10) [ 7 , 8 , 58 – 62 ], chemokines and adhesion molecules were elevated at the acute stage of KD [ 57 ]. Macrophage colony-stimulating factor (M-CSF) has been performed to play a critical role in the pathogenesis of KD and can be used as an indicator for the risks of valvulitis and coronary arteritis [ 11 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease

Kuo

Guo

et al. 2016

PLoS ONE

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Kawasaki disease (KD) or Kawasaki syndrome is known as a vasculitis of small to medium-sized vessels, and coronary arteries are predominantly involved in childhood. Generally, 20–25% of untreated with IVIG and 3–5% of treated KD patients have been developed coronary artery lesions (CALs), such as dilatation and aneurysm. Understanding how coronary artery aneurysms (CAAs) are established and maintained in KD patients is therefore of great importance. Upon our previous genotyping data of 157 valid KD subjects, a genome-wide association study (GWAS) has been conducted among 11 (7%) CAA-developed KD patients to reveal five significant genetic variants passed pre-defined thresholds and resulted in two novel susceptibility protein-coding genes, which are NEBL (rs16921209 (P = 7.44 × 10−9; OR = 32.22) and rs7922552 (P = 8.43 × 10−9; OR = 32.0)) and TUBA3C (rs17076896 (P = 8.04 × 10−9; OR = 21.03)). Their known functions have been reported to associate with cardiac muscle and tubulin, respectively. As a result, this might imply their putative roles of establishing CAAs during KD progression. Additionally, various model analyses have been utilized to determine dominant and recessive inheritance patterns of identified susceptibility mutations. Finally, all susceptibility genes hit by significant genetic variants were further investigated and the top three representative gene-ontology (GO) clusters were regulation of cell projection organization, neuron recognition, and peptidyl-threonine phosphorylation. Our results help to depict the potential routes of the pathogenesis of CAAs in KD patients and will facilitate researchers to improve the diagnosis and prognosis of KD in personalized medicine.

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Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease

Kuo

Guo

et al. 2016

PLoS ONE

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“…Intense IL-1β, tumor necrosis factor α and IL-6 are also produced in acute KD patients ( Figure 2 ) ( 22 , 30 , 31 ). IL-31 has also been reported to be involved in Th2-mediated diseases, such as allergic diseases, as well as KD ( 32 ). Eosinophils play an important role in type 2 inflammation ( 33 ).…”

Section: Abnormal Type 2 Inflammation Imbalance T Helper Type 17/regmentioning

confidence: 99%

Kawasaki Disease and Allergic Diseases

Huang

Guo

et al. 2021

Front. Pediatr.

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Background: Kawasaki disease (KD) is an inflammatory disorder with an unknown etiology. It is the leading cause of acquired heart disease, which leads to coronary vasculitis among children. Studies of frequent manifestation of allergic diseases in children with KD have been the subject of mounting clinical interest. However, evidence supporting the association between KD and allergies has yet to be systematically reviewed.Methods: In this article, we reviewed current literature regarding the association between KD and allergic diseases. References for this review were identified through searches of PubMed, Cochrane, and Embase through the end of August 2020.Results: The results of the analyses of immune repertoire, clinical, and epidemiological studies have indicated some of the characteristics of infectious disease for KD. Although some allergic disorders, such as asthma, may be exacerbated by viral infections, allergies are typically caused by an allergen that triggers an immune response, with the potential involvement of type 2 inflammation and immune disturbances leading to tissue remodeling in genetically susceptible hosts. The effect of intravenous immunoglobulin is multi-faceted and results in a decrease in activating Fc gamma receptor IIA and an increase in anti-inflammatory eosinophils. The findings from this review demonstrate that children who have suffered from KD are more likely to have allergic rhinitis than the general population and their siblings, a condition that lasts until the age of 17. When followed up as teenagers and adults, children with KD are more likely to develop urticaria.Conclusions: This review supports that allergic diseases, such as allergic rhinitis, have been demonstrated to increase following KD. Therefore, the importance of allergic diseases in patients with KD should be emphasized in long-term care. Interventions that include strategies for managing allergies in children with KD would be beneficial.

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“…As far as cardiovascular diseases are concerned, the involvement of IL-31 has been studied in Kawasaki's disease. In particular, a study demonstrated how IL-31 expression was related to Kawasaki's disease, and thus, its higher expression could be considered as a promoter of coronary lesions [ 60 ]. On the other hand, serum levels of ST2 in patients affected by heart failure and myocardial infarction were found to be elevated, and the increase of ST2 levels was proposed as a biomarker in forecasting the risk for a cardiac transplantation and the risk of heart failure [ 40 ].…”

Section: Il-31 and Il-33 In Diseasesmentioning

confidence: 99%

IL-33/IL-31 Axis: A Potential Inflammatory Pathway

Salvo

Ventura-Spagnolo

Casciaro

et al. 2018

Mediators of Inflammation

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Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases. IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signalling and regulates a huge amount of biological functions: it induces proinflammatory cytokines, regulates cell proliferation, and is involved also in tissue remodelling. On the other hand, IL-33 has been identified as an "alarmin" released from the epithelial cells and from different human tissues and organs after a damage following, that is, an inflammatory process. The aim of this literature review is to strengthen the hypothesis about an IL-31/IL-33 axis by evaluating the most recent studies linking these two cytokines. Literature data showed that, in many cases, IL-31 and IL-33 are linked to each other and that their expression is correlated with disease severity. The presence of one interleukin might stimulate the induction of the other, amplifying inflammation and the consequent detrimental processes. In a near future, influencing their balance could be helpful in modulating the first responses of the immune system in order to prevent the development of many inflammation-related diseases.

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IL-31 Associated with Coronary Artery Lesion Formation in Kawasaki Disease

Cited by 18 publications

References 30 publications

Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease

Genome-Wide Association Study Identifies Novel Susceptibility Genes Associated with Coronary Artery Aneurysm Formation in Kawasaki Disease

Kawasaki Disease and Allergic Diseases

IL-33/IL-31 Axis: A Potential Inflammatory Pathway

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