The Effect of Interval Training and Nettle Supplement on Glycemic Control and Blood Pressure in Men WithType 2 Diabetes

Ghalavand, Akbar; Motamedi, Pezhman; Delaramnasab, Mojtaba; Mostafa, Khodadoust

doi:10.15171/ijbsm.2017.08

Cited by 11 publications

(22 citation statements)

References 34 publications

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“…These exclusions were due to the following reasons: administered nettle in combination with other components ( n = 4), duplicate dataset ( n = 2), contained no placebo group ( n = 1), studies that did not provide sufficient data for outcomes ( n = 2). Finally, eight trials (Dabagh, S and Nikbakht, M, ; Dadvar et al, ; Ghalavand et al, ; Hassani et al, ; Khajeh‐Mehrizi et al, ; Kianbakht et al, ; Korani et al, ; Tarighat et al, ) were included in this meta‐analysis. Of these, six trials (Dabagh, S and Nikbakht, M, ; Dadvar et al, ; Ghalavand et al, ; Kianbakht et al, ; Korani et al, ; Tarighat et al, ) reported the effect of nettle on FBS, three articles (Kianbakht et al, ; Korani et al, ; Tarighat et al, ) on glycosylated hemoglobin, three articles (Hassani et al, ; Khajeh‐Mehrizi et al, ; Tarighat et al, ) on HOMA‐IR, and three trials (Khajeh‐Mehrizi et al, ; Korani et al, ; Tarighat et al, ) on insulin.…”

Section: Resultsmentioning

confidence: 99%

“…Participant's age ranged from 41 to 57 years. Two studies (Dabagh, S and Nikbakht, M, ; Ghalavand et al, ) were conducted exclusively on males, and two (Dadvar et al, ; Hassani et al, ) on females, whereas the other four trials were performed on both genders. Nettle dose ranged from 1.5 to 10 g/day, and intervention duration ranged from 8 to 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…In studies by Dabagh and Nikbakht (), Ghalavand et al (), Hassani et al (), and Dadvar et al (), there were three intervention groups (nettle, nettle + aerobic training, and aerobic training + placebo) and one placebo group. We considered the result of the nettle and placebo groups as one study and the result of the nettle + aerobic training and placebo + aerobic training groups as another study.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of nettle supplementation on T2DM has been considered in several human‐based randomized clinical trials (RCTs;Khajeh‐Mehrizi et al, ; Dabagh, S and Nikbakht, M, ; Ghalavand et al, ; Korani et al, ; Kianbakht et al, ; Dadvar et al, ; Tarighat et al, ; Hassani et al, ); however, the results are equivocal at best. Some studies (Korani et al, ; Khajeh‐Mehrizi et al, ; Dabagh, S and Nikbakht, M, 2016; Ghalavand et al, ; Kianbakht et al, ; Tarighat et al, ) have reported significant improvements in biochemical outcomes, in T2DM patients, as a result of nettle supplementation, whereas others have reported no improvement (Hassani et al, ; Dadvar et al, ).…”

Section: Introductionmentioning

confidence: 99%

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The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

Ziaei

Foshati

Hadi

et al. 2019

Phytotherapy Research

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Type 2 diabetes mellitus (T2DM) is a major health problem, worldwide, that is associated with increased morbidity and mortality. Several randomized controlled clinical trials (RCTs) have investigated the effect of nettle (Urtica dioica) supplementation on markers of glycemic status in patients with T2DM, with conflicting results. Therefore, the present study assessed the effect of nettle on some glycemic parameters in patients with T2DM. A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science, from database inception up to June 2019, to identify RCTs investigating the effect of nettle supplementation on glycemic markers, including fasting blood sugar (FBS) concentrations, insulin levels, homeostasis model assessment-estimated insulin resistance index, and glycosylated hemoglobin percentage in adults with T2DM. The Cochrane Collaboration tool was used to assess the methodological quality of the included studies. Results of this meta-analysis were reported based on the random effects model. Eight RCTs, comprising 401 participants, were included in the present systematic review and meta-analysis. Based on the Cochrane Collaboration risk of bias tool, five studies were considered as good quality, one was fair, and two studies were poor, respectively. The results of the meta-analysis revealed a significant reduction in FBS concentrations (weighted mean difference [WMD]: −18.01 mg/dl, 95% confidence interval [CI]: −30.04 to −5.97, p < .001, I 2 = 94.6%) following nettle supplementation. However, no significant reduction was observed in insulin levels (WMD: 0.83 Hedges' g, 95% CI: −0.26 to 1.92, p = .13, I 2 = 89.4%), homeostasis model assessment-estimated insulin resistance index (WMD: −0.22, 95% CI: −0.83 to 0.40, p = .49, I 2 = 69.2%), or glycosylated hemoglobin percentage (WMD: −0.77%, 95% CI: −1.77 to 0.22, p = .12, I 2 = 83.0%). The find-ings of the present study suggest that nettle supplementation may be effective in controlling FBS for T2DM patients. However, further studies are needed to confirm the veracity of these results. K E Y W O R D Sglycemic markers, meta-analysis, nettle, systematic review, type 2 diabetes mellitus

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

Ziaei

Foshati

Hadi

et al. 2019

Phytotherapy Research

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show abstract

“…To measure the body mass index (kg/m 2 ), weight (kg) was divided by squared height and BMI was calculated using the following formula: BMI = weight (kg)/height 2 (m). To estimate the percentage of body fat, the 3-SITE SKINFOLD (chest, Abdominal, and thigh) measurements were performed using the Jackson-Pollack (1978) formula (19,20), as follows:…”

Section: Anthropometric Indicesmentioning

confidence: 99%

Effect of Circuit Resistance Training and L-Carnitine Supplementation on Body Composition and Liver Function in Men with Non-Alcoholic Fatty Liver Disease

Mohammadi

Ghalavand

Delaramnasab

2019

Jundishapur J Chronic Dis Care

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Background: Exercises and L-carnitine supplementation are effective for liver function. Objectives: The purpose of this study was to compare effect of circuit resistance training and l-carnitine supplementation on body Composition and Liver Function in men with non-alcoholic fatty liver disease (NAFLD). Methods: In this semi-experimental study, 40 men with NAFLD were selected through purposive sampling and were randomly assigned to one of four groups includes: (1) resistance training, (2) supplement, (3) combined (exercise-supplement) and (4) control. Circuit resistance training was performed for 12 weeks, three sessions per week, with a training intensity of 40% -80% maximum one-repetition. In the combined and supplementation group, 10 mg L-carnitine supplement per kg body weight was consumed daily with three main meals. To analyze the data, dependent t-test and one-way analysis of variance were used at P ≤ 0.05.Results: After exercise, there was a significant decrease in body mass index and body fat percentage in the resistance training group and combined (exercise-supplement) group when compared to the control and supplementation groups. There was also a significant decrease in the level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the intervention groups including exercise, supplement, and combined (exercise-supplement) groups compared to the control group. The percentage of changes in AST and ALT was significantly higher in the combined group than in the training and supplement groups. Conclusions: According to the findings of this study, circuit resistance and complementary L-carnitine training are effective for improving liver function. This improvement was more evident in the combination of training and L-carnitine supplementation, and these shifts are independent of changes in body composition.

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Preparation of O/W nano-emulsion containing nettle and fenugreek extract and cumin essential oil for evaluating antidiabetic properties

2021

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The oil-in-water (O/W) nano-emulsion (NE) is expanded to enhance the bioavailability of hydrophobic compounds. The NE can be prepared by herbal extract and essential oil as herbal medicines for antidiabetic treatment. In the present study, the O/W NE was prepared by fenugreek extract (FE), nettle extract (NE), and cumin essential oil (CEO) using tween 80 and span 80 surfactants in an ultrasonic bath, at room temperature within 18 min. The antidiabetic property was evaluated by determining glucose absorption using cultured rat L6 myoblast cell line (L6) myotubes and insulin secretion using the cultured mouse pancreatic beta-cell (RIN-5) for NEs. The samples were investigated by dynamic light scattering (DLS) to examine the size distribution and size, zeta potential for the charge determination, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) to investigate morphology and size. The rheological properties were studied by viscosity. The sample stability was evaluated at different temperatures and days by DLS and SEM analyses. The cytotoxicity of samples was explored by MTT assay for HEK293 human cell line as a specific cell line originally derived from human embryonic kidney cells at three different concentrations for three periods of time. The NEs with nanometer-size were observed with antidiabetic properties, low cytotoxicity, and suitable stability. This study provides definitive evidence for the NE as a plant medicine with antidiabetic properties. The NE can be a good candidate for biomedical applications.

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The Effect of Interval Training and Nettle Supplement on Glycemic Control and Blood Pressure in Men WithType 2 Diabetes

Cited by 11 publications

References 34 publications

The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta‐analysis

Effect of Circuit Resistance Training and L-Carnitine Supplementation on Body Composition and Liver Function in Men with Non-Alcoholic Fatty Liver Disease

Preparation of O/W nano-emulsion containing nettle and fenugreek extract and cumin essential oil for evaluating antidiabetic properties

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