Effect of Circuit Resistance Training and L-Carnitine Supplementation on Body Composition and Liver Function in Men with Non-Alcoholic Fatty Liver Disease

Abstract

Background: Exercises and L-carnitine supplementation are effective for liver function. Objectives: The purpose of this study was to compare effect of circuit resistance training and l-carnitine supplementation on body Composition and Liver Function in men with non-alcoholic fatty liver disease (NAFLD). Methods: In this semi-experimental study, 40 men with NAFLD were selected through purposive sampling and were randomly assigned to one of four groups includes: (1) resistance training, (2) supplement, (3) combined (exercise-supplement) and (4) control. Circuit resistance training was performed for 12 weeks, three sessions per week, with a training intensity of 40% -80% maximum one-repetition. In the combined and supplementation group, 10 mg L-carnitine supplement per kg body weight was consumed daily with three main meals. To analyze the data, dependent t-test and one-way analysis of variance were used at P ≤ 0.05.Results: After exercise, there was a significant decrease in body mass index and body fat percentage in the resistance training group and combined (exercise-supplement) group when compared to the control and supplementation groups. There was also a significant decrease in the level of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the intervention groups including exercise, supplement, and combined (exercise-supplement) groups compared to the control group. The percentage of changes in AST and ALT was significantly higher in the combined group than in the training and supplement groups. Conclusions: According to the findings of this study, circuit resistance and complementary L-carnitine training are effective for improving liver function. This improvement was more evident in the combination of training and L-carnitine supplementation, and these shifts are independent of changes in body composition.

The Effects of L-Carnitine Supplementation During Concurrent Training on the Functional Capacities and Body Composition in Obese Men

“…In fact, regular use of carnitine would increase plasma and intracellular concentration of carnitine and increase in fat oxidation and gradually decrease body fat storage. 37 To our knowledge, this was the first reported case that simultaneously analyses for factors of L-carnitine, functional capacities, body composition of obese males in both resistance and endurance training. The changes mentioned earlier occurred without any change in the body composition or functional parameters.…”

“…In fact, regular use of carnitine would increase plasma and intracellular concentration of carnitine and increase in fat oxidation and gradually decrease body fat storage. 37…”

Effect of Exercise on Liver Function and Insulin Resistance Markers in Patients with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…There were 1316 participants included in this review (intervention groups: 800 participants; control groups: 516 participants). Of the 26 included studies, 10 studies exclusively recruited male subjects (n = 401) [28][29][30][31][32][33][34][35][36][37], 4 studies exclusively recruited female subjects (n = 303) [38][39][40][41],…”

The Effect of Atorvastatin and Continuous Aerobic Exercise on the Expression of Vascular Endothelial Growth Factor Beta Gene in the Liver Tissue of Diabetic Rats

“…Aerobic activities with clinical benefits, including improved insulin sensitivity, glycemic control, and increased maximal oxygen consumption (VO2mx), can prevent diabetes complications (1,12,16). One of the benefits of doing exercise is its effects on liver health (8). Statins are one of the main and most effective drugs that have beneficial effects on lipid profile.…”