“…The majority of evidence supports the benefits of exercise on total cholesterol [ 64 , 71 , 74 , 75 , 121 , 124 , 125 ], potentially driven by benefits on LDL-cholesterol [ 54 , 64 , 65 , 75 , 79 , 82 , 121 , 124 , 125 ]. While one meta-analysis demonstrated within-group benefits for exercise on hepatic insulin sensitivity [ 69 ], the efficacy for improving glycaemic control [ 54 , 65 , 73 , 75 , 79 , 80 ] and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) [ 25 , 50 , 54 , 59 , 60 , 66 , 67 , 70 , 76 , 123 ] in people with MAFLD is inconsistent. Small laboratory-based aerobic exercise trials have shown a benefit on endothelial function [ 136 ], peripheral insulin sensitivity [ 142 ] and novel risk factors such as thrombotic biomarker plasminogen activator inhibitor 1 (PAI-1) [ 139 ].…”