Abstract:Background: The aims of this study were to investigate the efficacy of CPP‐ACP containing Tooth Mousse on the remineralization of enamel lesions and to compare its efficacy to that of a fluoride‐containing toothpaste.Methods: Permanent teeth were placed in demineralizing solution for 96 hours to produce artificial caries‐like lesions 120–200 μm in depth. They were sectioned into 100–150 μm thick samples and randomly assigned to five groups: for Group A, a fluoridated toothpaste (1100 ppm) was used as a posit… Show more
“…Whereas in the present study, the CPP-ACP and CPP-ACFP crèmes were used as an adjunct to the fluoride treatment with 1450 ppm F. In their study, Kumar, et al (2008), revealed an additive effect for the application of the CPP-ACP crème after the fluoride toothpaste treatment, which is consistent with the results of the current study, however it was not reported whether this additional effect was statistical significance or not.…”
Section: Effect Of Cpp-acp and Cpp-acfp On Remineralising Enamel Subssupporting
confidence: 81%
“…The positive effect of CPP-ACP (Tooth Mousse) and CPP-ACFP (MI Paste Plus) in the remineralisation of enamel lesions has been shown in previous in vitro studies (Kumar et al, 2008, Jayarajan et al, 2011, Zhang et al, 2011. However, different methodologies were used in these studies compared to the current study.…”
Section: Effect Of Cpp-acp and Cpp-acfp On Remineralising Enamel Subsmentioning
The candidate confirms that the work submitted is her own and that appropriate credit has been given where reference has been made to the work of others. This copy has been supplied on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement. It was a great time that I spend with my friends and classmates
“…Whereas in the present study, the CPP-ACP and CPP-ACFP crèmes were used as an adjunct to the fluoride treatment with 1450 ppm F. In their study, Kumar, et al (2008), revealed an additive effect for the application of the CPP-ACP crème after the fluoride toothpaste treatment, which is consistent with the results of the current study, however it was not reported whether this additional effect was statistical significance or not.…”
Section: Effect Of Cpp-acp and Cpp-acfp On Remineralising Enamel Subssupporting
confidence: 81%
“…The positive effect of CPP-ACP (Tooth Mousse) and CPP-ACFP (MI Paste Plus) in the remineralisation of enamel lesions has been shown in previous in vitro studies (Kumar et al, 2008, Jayarajan et al, 2011, Zhang et al, 2011. However, different methodologies were used in these studies compared to the current study.…”
Section: Effect Of Cpp-acp and Cpp-acfp On Remineralising Enamel Subsmentioning
The candidate confirms that the work submitted is her own and that appropriate credit has been given where reference has been made to the work of others. This copy has been supplied on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgement. It was a great time that I spend with my friends and classmates
“…CPP-ACP products have shown an ability to prevent dental demineralization and increase remineralization of enamel and dentin in vitro (12,13), as well as to arrest initial enamel caries lesions in vivo (15)(16)(17). However, due to the lack of clinical trials, there is no consensus about the cariostatic effect of CPP-ACP.…”
Section: Discussionmentioning
confidence: 94%
“…Pastes containing a complex of casein phosphopeptide (CPP) and amorphous calcium phosphate (ACP), with or without fluoride, have shown potential to prevent dental demineralization, increase remineralization in vitro (10)(11)(12)(13)(14) and to repair initial enamel caries lesions in vivo as well (15)(16)(17). It has been suggested that casein phosphopeptides (CPP) have the ability to stabilize calcium phosphate in solution by binding amorphous calcium phosphate (ACP) with their multiple phosphoserine residues, thereby allowing the formation of small CPP-ACP clusters (18).…”
This in vitro study evaluated the preventive potential of experimental pastes containing 10% and 20% hydroxyapatite nanoparticles (Nano-HAP), with or without fluoride, on dental demineralization. Bovine enamel (n=15) and root dentin (n=15) specimens were divided into 9 groups according to their surface hardness: control (without treatment), 20 Nanop paste (20% HAP), 20 Nanop paste plus (20% HAP + 0.2% NaF), 10 Nanop paste (10% HAP), 10 Nanop paste plus (10% HAP + 0.2% NaF), placebo paste (without fluoride and HAP), fluoride paste (0.2% NaF), MI paste (CPP-ACP, casein phosphopeptide-amorphous calcium phosphate), and MI paste plus (CPP-ACP + 0.2% NaF). Both MI pastes were included as commercial control products containing calcium phosphate. The specimens were treated with the pastes twice a day (1 min), before and after demineralization. The specimens were subjected to a pH-cycling model (demineralization-6-8 h/ remineralization-16-18 h a day) for 7 days. The dental subsurface demineralization was analyzed using cross-sectional hardness (kgf/mm 2 , depth 10-220 µm). Data were tested using repeated-measures two-way ANOVA and Bonferroni's test (p<0.05). The only treatment able to reduce the loss of enamel and dentin subsurface hardness was fluoride paste (0.2% NaF), which differed significantly from the control at 30-and 50-µm depth (p<0.0001). The other treatments were not different from each other or compared with the control. The experimental Nanop pastes, regardless of the addition of fluoride, were unable to reduce dental demineralization in vitro.
“…Traces of demineralization, which cannot be foreseen, are often discovered at the end of treatment, requiring continued preventive fluoride treatment. In this case it is important to make topical applications of fluorides in a solution, gel or varnish to facilitate surface remineralization of incipient carious lesions [49,50]. Another study concerning remineralization with fluoride after removal of orthodontic devices has shown that the use of a fluoride toothpaste twice a day leads to remineralization after 2 months, and combining fluoride toothpaste and fluoride gels speeds up remineralization (1 month) [51].…”
Section: After the Orthodontic Treatmentmentioning
The formation of white spot lesions, or enamel demineralization, around fixed orthodontic attachments is a common complication during and following fixed orthodontic treatment, which marks the result of a successfully completed case. This article is a contemporary review of the risk factors and preventive methods of these orthodontics scars. Preventive programmes must be emphasized to all orthodontic patients. The responsibility of an orthodontist is to minimize the risk of the patient having decalcification as a consequence of orthodontic treatment by educating and motivating the patients for excellent oral hygiene practice. Prophylaxis with topical fluoride application should be implemented: high-fluoride toothpastes, fluoride mouthwashes, gels and varnishes during and after the orthodontic treatment, especially for patients at high risk of caries.
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