Comparison of the newer preventive therapies on remineralisation of enamel in vitro

Bataineh, M.; Malinowski, M.; Duggal, M. S.; Tahmassebi, J. F.

doi:10.1016/j.jdent.2017.08.013

Cited by 5 publications

(4 citation statements)

References 176 publications

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“…The duration of similar in vitro studies varies, going from 10 days 11 , 13 , 27 up to 21 days 23 , 28 . This is in contrast with the 6 and 12 weeks used in the current study.…”

Section: Discussionmentioning

confidence: 90%

“…The application of CPP-ACP(F) requires sufficient time to enable effective diffusion of nanoclusters through the surface layer of the white spot lesion. More recent studies, both in vitro and in vivo , were also unable to confirm the potential of CPP-ACP and CPP-ACPF in conjunction with a conventional toothpaste 28 33 , 34 On the other hand, the prescribed application time of 3 minutes of CPP-ACP(F) must not be extended to produce an additional effect.…”

Section: Discussionmentioning

confidence: 99%

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The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

Thierens¹,

Moerman²,

Elst³

et al. 2019

J. Appl. Oral Sci.

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Objective: The aim of this in vitro study was to determine the effects of remineralization promoting agents containing casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP), or CPP-ACP in combination with fluoride (CPP-ACPF) on artificial white spot lesions (WSLs) after 6 and 12 weeks. Methodology: White spot lesions were created on 123 sectioned premolars (246 specimens) with a demineralization solution during a 96 hours pH-cycling regime. Two experimental groups were created: a CPP-ACP group (Tooth Mousse™), and a CPP-ACPF group (Mi Paste Plus™). Additionally, two control groups were created, one using only a conventional toothpaste (1450 ppm fluoride) and another one without any working agents. All teeth were also daily brushed with the conventional toothpaste except the second control group. Tooth Mousse™ and Mi Paste Plus™ were applied for 180 seconds every day. The volume of demineralization was measured with transverse microradiography. Six lesion characteristics regarding the lesion depth and mineral content of WSLs were also determined. Results: The application of CPP-ACP and CPP-ACPF had a significant regenerative effect on the WSLs. Compared to Control group 1 and 2 the volume of demineralization after 6 weeks decreased significantly for CPP-ACP (respectively p <0.001 and p <0.001) and CPP-ACPF (respectively p =0.001 and p =0.003). The same trend was observed after 12 weeks. For the CPP-ACPF group, WSL dimensions decreased significantly between 6 and 12 weeks follow-up ( p =0.012). The lesion depth reduced significantly after application of CPP-ACP and CPP-ACPF but increased significantly in the Control groups. Mineral content increased for CPP-ACP and CPP-ACPF after an application period of 12 weeks, but this was only significant for CPP-ACP. Conclusions: Long-term use of CPP-ACP and CPP-ACPF in combination with a conventional tooth paste shows beneficial effects in the recovery of in vitro subsurface caries lesions.

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“…The duration of similar in vitro studies varies, going from 10 days 11 , 13 , 27 up to 21 days 23 , 28 . This is in contrast with the 6 and 12 weeks used in the current study.…”

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

Thierens¹,

Moerman²,

Elst³

et al. 2019

J. Appl. Oral Sci.

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show abstract

“…In the presence of fluorides, formation of CPP-ACFP nano-complexes takes place, and when the pH falls, breakage of the nano-complex leads to formation of calcium ions, phosphate ions, and neutral species CaHPO4 and HF. These ions following concentration gradient move inside the subsurface lesion, thus leading to formation of fluorapatite [18,21,22].The resultingsurface would probably be much more cariesresistant compared to theoriginal enamel, but it still retains a demineralized appearance [23].…”

Section: Resultsmentioning

confidence: 99%

Comparative Evaluation of Casein Phosphopeptide - Amorphous Calcium Phosphate and Fluoride in Managing Early Caries Lesions

Bobu¹,

Murariu²,

Topor³

et al. 2019

Rev. Chim.

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The aim of the present study was to assess the remineralizing potential of 10% casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP) -Recaldent used alone or with fluoride (CPP-ACFP) as compared to fluoride mouthrinse for the non-invasive treatment of occlusal non-cavitary caries lesions in vivo.A total of eighty subjects were randomly assigned to four groups, i.e. group 1 - 10% CPP-ACP, group 2- 10% CPP-ACP + 0.2% NaF, group 3- 0.05% NaF mouthrinse and group 4 �control. The lesions were assessed using visual examination and DIAGNOdent measurements. After 12 weeks of using the corresponding product, the results showed that the highest decrease in fluorescence was produced by CPP-ACFP (from 16.28�1.40 to 6.53�0.59, p=0.002), followed by CPP-ACP (from 15.70�1.82 to 8.18�0.70, p=0.004) and fluoride mouthrinse (from 14.32�1.72 to 7.88�0.68, p=0.005), significantly higher than in the control group (p[0.05). No significant differences were found between the three treatment groups.

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“…The team further validated the preventive effect of CPP-ACP on enamel demineralization in a rat caries model (Reynolds et al, 1995). With the U.S. Food and Drug Administration and other regulatory agencies confirming the biosafety of CPP-ACP (Cochrane et al, 2010), CPP-ACP is added into oral health care products such as Tooth Mousse (GC, Tokyo, Japan) (Rees et al, 2007) and Tooth Mousse Plus (CPP-ACPF, GC, Tokyo, Japan) (Hamba et al, 2011;Bataineh et al, 2017;Olgen et al, 2021). These agents have been gradually used in clinical practice and have been studied in a number of clinical trials (Sitthisettapong et al, 2015;Güçlü et al, 2016;Munjal et al, 2016;Thierens et al, 2019).…”

Section: Casein Phosphopeptidesmentioning

confidence: 99%

Application of Amorphous Calcium Phosphate Agents in the Prevention and Treatment of Enamel Demineralization

Yan

Yang

Luo

et al. 2022

Front. Bioeng. Biotechnol.

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Enamel demineralization, as a type of frequently-occurring dental problem that affects both the health and aesthetics of patients, is a concern for both dental professionals and patients. The main chemical composition of the enamel, hydroxyapatite, is easy to be dissolved under acid attack, resulting in the occurrence of enamel demineralization. Among agents for the preventing or treatment of enamel demineralization, amorphous calcium phosphate (ACP) has gradually become a focus of research. Based on the nonclassical crystallization theory, ACP can induce the formation of enamel-like hydroxyapatite and thereby achieve enamel remineralization. However, ACP has poor stability and tends to turn into hydroxyapatite in an aqueous solution resulting in the loss of remineralization ability. Therefore, ACP needs to be stabilized in an amorphous state before application. Herein, ACP stabilizers, including amelogenin and its analogs, casein phosphopeptides, polymers like chitosan derivatives, carboxymethylated PAMAM and polyelectrolytes, together with their mechanisms for stabilizing ACP are briefly reviewed. Scientific evidence supporting the remineralization ability of these ACP agents are introduced. Limitations of existing research and further prospects of ACP agents for clinical translation are also discussed.

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Comparison of the newer preventive therapies on remineralisation of enamel in vitro

Cited by 5 publications

References 176 publications

The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

Comparative Evaluation of Casein Phosphopeptide - Amorphous Calcium Phosphate and Fluoride in Managing Early Caries Lesions

Application of Amorphous Calcium Phosphate Agents in the Prevention and Treatment of Enamel Demineralization

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