The Effect of Arsenic on the Toxicity of Seleniferous Grains

Associations of Plasma Selenium with Arsenic and Genomic Methylation of Leukocyte DNA in Bangladesh

“…Antagonistic effects between As and Se have been well documented since the original discovery by Moxon (1938) that cattle could be protected from Se toxicity by treatment with As. Several studies have indicated that As and Se each mutually facilitate excretion of the other in bile (Levander 1977).…”

Selenium Deficiency and Toxicity in the Environment

“…Sodium sulfate and high protein intakes have been shown to reduce the toxicity of selenate to rats but not of selenite or selenomethionine in wheat. Arsenic, silver, mercury, copper and cadmium have all been shown to decrease the toxicity of selenium to laboratory animals and have been used to alleviate selenium poisoning in dogs, pigs, chicks and cattle (WHO, 1987;Levander, 1986;Moxon, 1938). The protective effect of arsenic is thought to be a consequence of increased biliary selenium excretion.…”

Biological interaction of selenium with other trace elements in chicks.

“…The discovery that the biological effects of selenium could be modified by other elements dates back to the work of Moxon (1), who reported that arsenic counteracted the toxic effects of seleniferous grain. This was found to be true in rats (I), pigs (2), dogs (3), and chicks (4).…”