Associations of Plasma Selenium with Arsenic and Genomic Methylation of Leukocyte DNA in Bangladesh

Pilsner, J. Richard; Hall, Megan N.; Liu, Xinhua; Ahsan, Habibul; Ilievski, Vesna; Slavkovich, Vesna; Levy, Diane; Factor-Litvak, Pam; Gamble, Mary V.

doi:10.1289/ehp.1001973

Cited by 27 publications

(20 citation statements)

References 50 publications

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“…The study results were consistent with earlier in vitro findings (i.e. Se is inversely associated with genomic DNA methylation), suggesting that high levels of Se are associated with a decrease in DNMT expression and/or activity (65) .…”

Section: Role Of Selenium In Dna Methylation Changessupporting

confidence: 92%

Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention

et al. 2012

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There is evidence from epidemiological studies suggesting that increased consumption of cruciferous vegetables may protect against specific cancers more effectively than total fruit and vegetable intake. These beneficial effects are attributed to the glucosinolate breakdown products, isothiocyanates (ITC). Similarly, selenium (Se) consumption has also been inversely associated with cancer risk and as an integral part of many selenoproteins may influence multiple pathways in the development of cancer. This paper will briefly review the current state of knowledge concerning the effect of Se and ITC in cancer development with a particular emphasis on its antioxidant properties, and will also address whether alterations in DNA methylation may be a potential mechanism whereby these dietary constituents protect against the carcinogenic process. Furthermore, we will discuss the advantages of combining ITC and Se to benefit from their complementary mechanisms of action to potentially protect against the alterations leading to neoplasia. Based on this review it may be concluded that an understanding of the impact of ITC and Se on aberrant DNA methylation in relation to factors modulating gene-specific and global methylation patterns, in addition to the effect of these food constituents as modulators of key selenoenzymes, such as gastrointestinal glutathione peroxidase-2 (GPx2) and thioredoxin reductase-1 (TrxR1), may provide insights into the potential synergy among various components of a plant-based diet that may counteract the genetic and epigenetic alterations that initiate and sustain neoplasia.

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Section: Role Of Selenium In Dna Methylation Changessupporting

confidence: 92%

Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention

et al. 2012

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“…Promoter analysis of this gene revealed decreased association of DNMT1 and methylation of H3K9, and increased acetylation of this histone residue in selenite-treated cells [66] . One recent study in humans showed that selenium plasma levels were inversely correlated with genomic DNA methylation in leukocytes [71] ; the health implications of these findings require further study.…”

Section: Seleniummentioning

confidence: 99%

Targeting the Epigenome with Bioactive Food Components for Cancer Prevention

2011

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Epigenetic processes participate in cancer development and likely influence cancer prevention. Global DNA hypomethylation, gene promoter hypermethylation and aberrant histone posttranslational modifications are hallmarks of neoplastic cells which have been associated with genomic instability and altered gene expression. Because epigenetic deregulation occurs early in carcinogenesis and is potentially reversible, intervention strategies targeting the epigenome have been proposed for cancer prevention. Bioactive food components (BFCs) with anticancer potential, including folate, polyphenols, selenium, retinoids, fatty acids, isothiocyanates and allyl compounds, influence DNA methylation and histone modification processes. Such activities have been shown to affect the expression of genes involved in cell proliferation, death and differentiation that are frequently altered in cancer. Although the epigenome represents a promising target for cancer prevention with BFCs, few studies have addressed the influence of dietary components on these mechanisms in vivo, particularly on the phenotype of humans, and thus the exact mechanisms whereby diet mediates an effect on cancer prevention remains unclear. Primary factors that should be elucidated include the effective doses and dose timing of BFCs to attain epigenetic effects. Because diet-epigenome interactions are likely to occur in utero, the impact of early-life nutrition on cancer risk programming should be further investigated.

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“…Also, cases of Deg Nala disease have been successfully treated using proprietary pentasulfate mixture based on sulfur and Se antagonism [279]. Antagonism between arsenic (As) and Se, whereby each reduces the toxicity of the other, has been reported in animal models [281,282]. Proper management of the wound is recommended for complete recovery of the animal.…”

Section: Deg Nala Diseasementioning

confidence: 99%

Emerging Infectious Diseases in Water Buffalo: An Economic and Public Health Concern

Villanueva¹,

Mingala²,

Tubalinal³

et al. 2018

Emerging Infectious Diseases in Water Buffalo - An Economic and Public Health Concern

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Water buffalo is an indispensable livestock in Asia and other countries due to its high meat and milk quality, aside from draft power source. It adapts well to tropical climate and has significant contribution to the livestock industry, provided with improved breeding and good animal husbandry practices. Infectious diseases are hindrance to good reproductive performance of livestock, resulting in huge economic loss. In addition, most of these diseases are zoonotic, posing serious threats on human health. However, its degree of severity varies in each region and is often overlooked. This chapter reviews the common and current updates on emerging bacterial, viral, protozoal, fungal and endoparasitic pathogens that infect water buffaloes worldwide. All of the diseases directly affect the animals' health condition except for schistosomiasis where water buffalo played an important role as shedder of infection to humans. Leptospirosis, brucellosis, Bovine Tb, BVDV and fasciolosis have projected economic impact to water buffalo industry as well as its effect as zoonoses. However, the data seem underquantified since most are neglected diseases and are highly prevalent in developing countries. Further studies are needed particularly in countries where water buffalo is the major livestock than cattle to fully utilize the potential of the animal.

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Associations of Plasma Selenium with Arsenic and Genomic Methylation of Leukocyte DNA in Bangladesh

Cited by 27 publications

References 50 publications

Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention

Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention

Targeting the Epigenome with Bioactive Food Components for Cancer Prevention

Emerging Infectious Diseases in Water Buffalo: An Economic and Public Health Concern

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