The dominance of a multiresistant strain of Neisseria gonorrhoeae among prostitutes and STD patients in The Gambia.

Ison, Catherine; Pépin, Jacques; Roope, N. S.; Demba, Edward; Secka, Ousman; Easmon, C. S. F.

doi:10.1136/sti.68.6.356

Cited by 21 publications

(18 citation statements)

References 13 publications

(4 reference statements)

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“…In this study the gonococcal population was heterogeneous, although there were fewer serovars and A/S classes among the PPNG than the non-PPNG. We have encountered this phenomenon in other studies both in London, UK [25] and in The Gambia [26]. Serovar IA-6 strains were the most frequently detected in this study and have been reported as one of the predominant serovars in Kenya [24].…”

Section: Resultssupporting

confidence: 60%

Antimicrobial susceptibilities and serotyping of Neisseria gonorrhoeae in southern Africa: influence of geographical source of infection

et al. 1993

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SUMMARYOne hundred and ninety-two strains of Neisseria gonorrhoeae isolated from migrant mine-workers were tested for their susceptibility to antibiotics, auxotyped and serotyped. Of the total, 93 (48%) were acquired locally and 64 (33%) from different geographical locations. Plasmid-mediated resistance to penicillin was found in 28 (14-6%) strains and was associated predominantly with the presence of 5 0 kb penicillinase encoding plasmid (18/28, 64 %). Chromosomal resistance to penicillin (MIC ) 1 mg/l) was detected in 14 (73 0%) strains. Resistance to tetracycline was chromosomally and not plasmid-mediated. Antibiotic resistance was encountered most commonly among strains acquired in Natal. The overall gonococcal population was sensitive to ceftriaxone, ciprofloxacin, spectinomycin and azithromycin. Nine auxotype/serovar (A/S) classes were encountered among penicillinase-producing N. gonorrhoeae (PPNG) compared to 24 A/S classes among non-PPNG strains. The most common A/S class was NR/IA-6 which accounted for 38 % of PPNG and 15 % of non-PPNG.

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Section: Resultssupporting

confidence: 60%

Antimicrobial susceptibilities and serotyping of Neisseria gonorrhoeae in southern Africa: influence of geographical source of infection

et al. 1993

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“…The isolation of penicillinase-producing Neisseria gonorrhoeae strains (PPNG) was described for the first time by both Philips (1976) and Ashford et al (1976). Thereafter, PPNG strains presenting an higher resistance to penicillin have been isolated and its number increased rapidly allover the world: Nigeria 3% in 1979 to 48% in 1984 (Lind, 1991); Senegal 21% in 1984 (Lind, 1991); Gabon 48% in 1984 (Ison, 1992); Zaire 59% in 1988(Van Dyck, 1992and Portugal 19.2% in 1985to 50% in 1995(Ferreira, 1997. These strains harboured the 4.5 MDa or 3.2 MDa plasmid in conjunction with or without the 24.5 MDa conjugative plasmid, defining the rapid diffusion of the resistance.…”

Section: Introductionmentioning

confidence: 99%

GUINEA-BISSAU'S PLANTS: IN VITRO SUSCEPTIBILITY STUDIES ON NEISSERIA GONORRHOEAE

Silva

Ferreira

Pato

et al. 1997

International Journal of Pharmacognosy

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Extracts from different parts of Cassia sieberiana, Chamaechrista nigricans, Guiera senegalensis, Lippia chevalieri, Pavetta oblongifolia, Piliostigma thonningii, Senna podocarpa and Terminalia macroptera were examined for in vitro antibacterial activity. These species were collected in the Contuboel region (Guinea-Bissau) which were used by the traditional healer's of the Fulani ethny to treat several disorders including venereal diseases (Diniz, 1996). Fifteen plant extracts were tested against nine strains ofNeisseria gonorrhoeae, including penicillin and tetracycline resistant strains. All the extracts exhibited antibacterial activity against all the tested strains. Two of the most active extracts (from Guiera senegalensis leaves and Terminalia macroptera root) were partitioned with different solvents and tested for antiNeisseria gonorrhoeae activity.

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“…4 Appropriate and effective treatment requires updated information about susceptibility patterns. Because of the emergence of drug resistant strains like penicillinase producing N. gonorrhoeae (PPNG), plasmid-mediated tetracycline resistance (TRNG), and chromosomally mediated resistance to penicillin and/or tetracycline (CMRNGPT), the Centers for Disease Control and Prevention, Atlanta, has advocated the use of expandedgeneration cephalosporin or fluoroquinolones as the first line of therapy for uncomplicated gonorrhea.…”

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confidence: 99%

Gonococcal infections: The trends of antimicrobial susceptibility of Neisseria gonorrhoeae in Western Nepal

Bhatta

Gokhale

et al. 2012

Nep J Med Sci

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Background: Gonorrhea is caused by Neisseria gonorrhoeae, is an important public health problem and is the second most common reportable sexually transmitted bacterial infection. Present study was conducted to determine the antimicrobial resistance pattern of Neisseria gonorrhoeae isolates from various clinical specimens. Methods: This is a hospital based retrospective study conducted at Manipal Teaching Hospital, Pokhara, Nepal. Various clinical specimens (urethral, cervical and conjunctival discharges) were collected from the suspected cases of gonococcal infections between January 2004 to December 2010. Specimens were subjected to Gram stain and culture on chocolate agar. Antibiotic susceptibility testing was performed on chocolate agar by Kirby Bauer’s disc diffusion method. Results: A total of 119 patients were tested for gonococcal infections. Forty-eight patients were diagnosed as having gonococcal infections, of which 40 cases were culture positive. Penicillin resistance was seen in 27 (67%) cases while all isolates were sensitive to ceftriaxone. Conclusion: Neisseria gonorrhoeae isolates are becoming increasingly resistant to antibiotics like penicillin, ciprofloxacin and tetracycline. Therefore, continuous surveillance of antibiotic resistance pattern is required in order to start empirical antibiotic therapy in high risk population like commercial sex workers. DOI: http://dx.doi.org/10.3126/njms.v1i2.6603 Nepal Journal of Medical Sciences. 2012;1(2): 74-78

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The dominance of a multiresistant strain of Neisseria gonorrhoeae among prostitutes and STD patients in The Gambia.

Cited by 21 publications

References 13 publications

Antimicrobial susceptibilities and serotyping of Neisseria gonorrhoeae in southern Africa: influence of geographical source of infection

Antimicrobial susceptibilities and serotyping of Neisseria gonorrhoeae in southern Africa: influence of geographical source of infection

GUINEA-BISSAU'S PLANTS: IN VITRO SUSCEPTIBILITY STUDIES ON NEISSERIA GONORRHOEAE

Gonococcal infections: The trends of antimicrobial susceptibility of Neisseria gonorrhoeae in Western Nepal

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