G<scp>UINEA</scp>-B<scp>ISSAU'S</scp> P<scp>LANTS: <i>IN VITRO</i></scp> S<scp>USCEPTIBILITY</scp> S<scp>TUDIES ON</scp> <i>N<scp>EISSERIA GONORRHOEAE</scp></i>

Silva, Olga; Ferreira, Eugénia; Pato, M. V. Vaz; Gomes, Eduardo

doi:10.1080/09251619708951276

Cited by 22 publications

(27 citation statements)

References 9 publications

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“…Regarding the plants being used by the traditional medicine for treatment of neurologic disorders it may be possible to obtain a validation for many of their uses by pharmacologic tests, as has already happened with other types of plant uses by the traditional medicine in GuineaBissau [37][38][39]. Validations could be followed by toxicology and dosage tests with a view to return the knowledge to the populations.…”

Section: Discussionmentioning

confidence: 99%

Medicinal Plants Used to Treat Neurological Disorders in West Africa: A Case Study with Guinea-Bissau Flora

Romeiras¹,

Cristina²,

Indjai³

et al. 2012

AJPS

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The sub-Saharan region holds a wide variety of indigenous plant species, still offering the possibility to discover very interesting new natural products with potential therapeutic value. Most of the African population depends on traditional medicine for primary health care, however, neurological disorders are often not considered as common diseases and many people with mental illnesses, like epilepsy, are severely affected by health-related stigma and discrimination. Epilepsy is the most common serious chronic brain disorder, estimated to affect at least 10 million people in Africa. Guinea-Bissau is located in West Africa, and its population is mainly rural with very few health services available. Since the earliest times, Guinea-Bissau flora has constituted the main source of materials used in folk medicine and the local population, who is well versed in the uses of these plants and their properties. The aim of this study was to document the existing knowledge and practices related to the treatment of neurological disorders, namely epilepsy and seizures, in Guinea-Bissau and in other West African countries. The results presented from this study provide information not only on the specific plants used to treat neurological disorders, but also on social knowledge brought in by various ethnic groups, each one having its own culture, beliefs and ways of nature appropriation. Taking into account the existing knowledge on the medicinal properties of plants for treatment of neurologic disorders, it is believed that research in the areas of ethnomedicine and ethnopharmacology in Guinea-Bissau can bring promising results capable of adding value to the very rich natural resources of this country of West Africa.

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Section: Discussionmentioning

confidence: 99%

Medicinal Plants Used to Treat Neurological Disorders in West Africa: A Case Study with Guinea-Bissau Flora

Romeiras¹,

Cristina²,

Indjai³

et al. 2012

AJPS

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“…1). Tml had similar antibacterial activity to Tmr in the range of the tested concentrations (400^12.5 Wg ml 31 ) [12] (Fig. 1).…”

Section: Resultsmentioning

confidence: 60%

“…2) [16]. It will be interesting to use di¡erent phytochemical methods to determine the active compounds in Tml-2 which contain ellagic and gallic derivatives.…”

Section: Resultsmentioning

confidence: 99%

“…[11]. Recent studies on plants used in Guinea-Bissau's traditional medicine showed that extracts from plants used against venereal diseases presented in vitro activity against N. gonorrhoeae strains with di¡erent susceptibilities to penicillin and tetracycline [12]. Ethanol extract of T. macroptera (Tmr) root was one of the most active, with a minimum inhibitory concentration (MIC) of between 100 Wg ml 31 and 200 Wg ml 31 .…”

Section: Introductionmentioning

confidence: 99%

“…The most active fractions of this extract are the diethyl ether fraction (Tmr-2) and water fractions (Tmr-3, Tmr-5). Ellagic acid, gallic acid, punicalagin, terchebulin, 3,3P-di-O-methylellagic acid, 3,4,3P,4P-tetra-O-methylellagic acid and ter£avin A were isolated and identi¢ed in these fractions [12,13].…”

Section: Introductionmentioning

confidence: 99%

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In vitro anti-Neisseria gonorrhoeae activity of Terminalia macroptera leaves

Silva

2002

FEMS Microbiology Letters

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We used the agar dilution method to evaluate the antibacterial effect of Terminalia macroptera leaf (Tml) extract against nine reference and clinical Neisseria gonorrhoeae strains, including penicillin-and tetracycline-resistant and -susceptible strains. Tml possesses anti-N. gonorrhoeae activity against all of the strains and the minimum inhibitory concentrations (MIC) were between 100 and 200 Wg ml 31 . We then used a liquid^liquid partition method to divide the Tml extract into five fractions and determined the anti-N. gonorrhoeae activity of each of the fractions. All of the fractions showed antibacterial activity. The most active one was identified as the diethyl ether fraction and had MIC values of between 25 and 50 Wg ml 31 against all of the strains.

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Chemical constituents and antimicrobial activity of medicinal plants from Ghana: Cassia sieberiana, Haematostaphis barteri, Mitragyna inermis and Pseudocedrela kotschyi

Asase

Kokubun

Grayer

et al. 2008

Phytotherapy Research

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The antimicrobial activity of the sequential n-hexane, acetone and 50% aqueous methanol extracts of leaves, stem bark and roots of four species of medicinal plants, Cassia sieberiana DC. (Leguminosae), Haematostaphis barteri Hook. f. (Anacardiaceae), Mitragyna inermis (Willd.) O. Kuntze (Rubiaceae) and Pseudocedrela kotschyi (Schweinf.) Harms (Meliaceae), from Ghana were tested against Bacillus subtilis, Pseudomonas syringae and Cladosporium herbarum using TLC direct-autobiographic methods. Extracts from leaves, stem bark and roots of the four species gave a positive result against at least one test organism. Twelve of the 36 extracts were active against B. subtilis, four extracts were active against P. syringae and six were active against C. herbarum. Preliminary chemical analysis revealed the presence of flavonoids, stilbenes and alkaloids. This is the first report of a stilbene from the Anacardiaceae.

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GUINEA-BISSAU'S PLANTS: IN VITRO SUSCEPTIBILITY STUDIES ON NEISSERIA GONORRHOEAE

Cited by 22 publications

References 9 publications

Medicinal Plants Used to Treat Neurological Disorders in West Africa: A Case Study with Guinea-Bissau Flora

Medicinal Plants Used to Treat Neurological Disorders in West Africa: A Case Study with Guinea-Bissau Flora

In vitro anti-Neisseria gonorrhoeae activity of Terminalia macroptera leaves

Chemical constituents and antimicrobial activity of medicinal plants from Ghana: Cassia sieberiana, Haematostaphis barteri, Mitragyna inermis and Pseudocedrela kotschyi

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