In vitro anti-Neisseria gonorrhoeae activity of Terminalia macroptera leaves

Abstract

We used the agar dilution method to evaluate the antibacterial effect of Terminalia macroptera leaf (Tml) extract against nine reference and clinical Neisseria gonorrhoeae strains, including penicillin-and tetracycline-resistant and -susceptible strains. Tml possesses anti-N. gonorrhoeae activity against all of the strains and the minimum inhibitory concentrations (MIC) were between 100 and 200 Wg ml 31 . We then used a liquid^liquid partition method to divide the Tml extract into five fractions and determined the anti-N. gonorrhoeae activity of each of the fractions. All of the fractions showed antibacterial activity. The most active one was identified as the diethyl ether fraction and had MIC values of between 25 and 50 Wg ml 31 against all of the strains.

Antipsychotic-like effect of ethyl acetate fraction of Terminalia macroptera leaf in mice

“…It is widely distributed in West Africa, occurring from Senegal, to Cameroun occasionally as far as Sudan and Uganda ( Arbonnier, 2004 ). Literature survey reveals that T. macroptera possess various pharmacological properties including antianxiety ( Bum et al, 2012 ), antioxidant ( Zou et al, 2014 , Kone et al, 2012 ), Immunomodulatory ( Zou et al, 2014 ) and antimicrobial ( Pham et al, 2011 , Silva et al, 2002 ) effects. From a methanol extract of the leaves of the medicinal tree Terminalia macroptera, cis -polyisoprene, chebulic acid trimethyl ester, methyl gallate, shikimic acid, corilagin, rutin, narcissin, chebulagic acid, and chebulinic acid, were isolated.…”

Resistência Aos Antibióticos Em Neisseria Gonorrhoeae – Passado, Presente E Futuro

“…• 45 . O desenvolvimento de uma vacina para Neisseria gonorrhoeae é dificultado pela elevada variabilidade genómica e antigénica da bactéria, pelo que não se prevê que uma vacina capaz de induzir uma proteção eficaz e duradoura esteja a breve trecho disponível.…”

DPPH Radical Scavenging and Xanthine Oxidase Inhibitory Activity of Terminalia macroptera Leaves

“…All parts of the tree are widely used in traditional medicine. The root is used against hepatitis, gonorrhea and sexually transmitted diseases [1,2]. Preparations from the leaves are employed in the treatment of hepatitis, ringworm, skin diseases [3] as well as gastritis, colic, high blood pressure, fever and tuberculosis [4].…”

“…Triterpenoids, tannins and other phenolics are found in the bark [1,[7][8][9]. Phenolic acids, flavonoids and ellagitannins have been identified in the leaves [2,9]. The leaves have antibacterial [2] and antifungal activities [10].…”

“…Phenolic acids, flavonoids and ellagitannins have been identified in the leaves [2,9]. The leaves have antibacterial [2] and antifungal activities [10]. As part of our research on Malian medicinal plants [11], we have isolated and identified antioxidant compounds from T. macroptera leaves.…”