The Differential Effect of Low-Dose Mixtures of Four Pesticides on the Pea Aphid Acyrthosiphon pisum

Abstract

The modes of action of most insecticides are known, but little information exists regarding the toxicological interactions involving insecticide mixtures at low doses. The effects of mixtures of four insecticides were investigated using LC10 values (concentration leading to 10% mortality), acetamiprid (ACE, 0.235 µg/mL), chlorpyriphos (CHL, 107.0 µg/mL), deltamethrin (DEL, 5.831 µg/mL), and fipronil (FIP, 3.775 µg/mL) on the larvae of the pea aphid, Acyrthosiphon pisum. After 24 h exposure, 6 of the 11 tested combinations, DEL/FIP, ACE/DEL, CHL/FIP, ACE/DEL/FIP, ACE/CHL/FIP, and ACE/DEL/CHL/FIP, were toxic through an additive effect. Four combinations, ACE/FIP, DEL/CHL, ACE/CHL, and ACE/DEL/CHL had a synergistic effect, whereas only one DEL/CHL/FIP showed an antagonistic effect. The toxic effect of these mixtures was confirmed after 48 h of exposure, revealing an enhanced toxicity of CHL, DEL, and FIP in combination with ACE. We suggest that an insect pest management strategy should be evaluated in the future using different combinations of insecticides.

Neonicotinoid insecticides differently modulate acetycholine‐induced currents on mammalian α7 nicotinic acetylcholine receptors

“…Our hypothesis would be supported by the finding that clothianidin or acetamiprid enhanced ACh‐evoked currents after pretreatment. However, as previously demonstrated using the combination of several pesticides (Yi et al, ; Taillebois and Thany, ), our results could be due to additive, synergistic or antagonist effects of the three neonicotinoids with ACh, on the α7 nAChRs. Our data also suggest that the three neonicotinoid insecticides have complex effects on mammalian neuronal nAChRs.…”

Synergistic and antagonistic effects of insecticide binary mixtures against house flies (Musca domestica)

“…First, detoxification degrees of mixture compounds are different in living organisms and achieving the target sites by different compounds takes different amounts of time (Eremina & Ibragimkhalilova, 2010). Next, the chemical structure of compounds could change the toxicological effect of mixtures like this as has been suggested for fipronil (Taillebois & Thany, 2016). Finally, compounds of mixtures may have dose-dependent secondary effects, particularly in living organisms, resulting inchanges in the toxicological effect of mixtures (Ritz &Streibig, 2014).…”

“…Mixtures of commonly used pyrethroids and organophosphates have been evaluated against many insects including Culex quinquefasciatus Say (Corbel et al, 2003), Spodoptera litura F. (Ahmad et al, 2009), Acyrthosiphon pisum Harris (Taillebois & Thany, 2016), Plutella xylo-stella L. (Nasir et al, 2013) and M. domestica (Khan et al, 2013b). Сombinations of these insecticides with phenylpyrazole fipronil or avermectins (like abamectin, emamectin) have been also studied against, for example, Anopheles gambiae (Ngufor et al, 2017), Frankliniella occidentalis (Cloyd & Raudenbush, 2014), P. xylostella (Nasir et al, 2013) and M. domestica (Khan et al, 2013b;Abbas et al, 2015).…”

Evaluation of the Efficiency of Certain Attractive Toxic Baits for the Control of the House Fly, Musca domestica (Diptera: Muscidac)

“…Boron compounds were the standard chemical use for control of larval moscoid fly population in manure [97][98][99][100][101][102][103][104][105], sewage ludge [106][107][108][109][110][111] and compost [112]. Recently, Hinkle et al [113,114] …”