The diagnostic value of the combination of hemoglobin, CA199, CA125, and HE4 in endometriosis

Abstract

Background We aimed to analyze the differences in the peripheral blood cells and tumor biomarkers between the patients with endometriosis and healthy people, and establish a more efficient combined diagnostic model. Methods We retrospectively analyzed the differences in the peripheral blood cells and tumor biomarkers between the patients with endometriosis and healthy people. Binary logistic regression analysis was used to establish a combined diagnostic model. We plotted the receiver operator characteristic (ROC) curve to analyze the diagnostic efficiency of different diagnostic indexes. Results Compared with patients in the control group, patients in the endometriosis group had significantly lower eosinophil% (p = 0.045), neutrophil (p = 0.001), lymphocyte (p < 0.001), red blood cells (RBCs) (p < 0.001), and hemoglobin (HGB) (p < 0.001), and had significantly higher monocyte% (p = 0.008), monocyte‐to‐lymphocyte ratio (MLR) (p = 0.001), platelet‐to‐lymphocyte ratio (PLR) (p < 0.001), carbohydrate antigen (CA)‐199 (p < 0.001), CA125 (p < 0.001), human epididymis protein (HE)‐4 (p < 0.001), and the risk of ovarian malignancy algorithm (ROMA) (p < 0.001). The combined diagnostic model of HGB, CA199, CA125, and HE4 was established by binary logistic regression analysis. The ROC curve showed that the combined diagnostic model reached a sensitivity of 85.4%, a specificity of 78.83%, and an area under the curve of 0.900, which was significantly higher than that of the individual index in endometriosis diagnosis. Conclusion The combined diagnostic model of HGB, CA199, CA125, and HE4 may provide a new approach for the early non‐invasive diagnosis of endometriosis.

Treatment of endometriosis with dienogest in combination with traditional Chinese medicine: A systematic review and meta-analysis

“…It has also been shown that VEGF, MMP-2 and MMP-9 are significantly elevated in the serum of patients with endometriosis ( 62 ). In contrast, CA-125 and CA-199 are significantly increased in the serum of patients with endometriosis and together with some other serological indicators can be used as a reference for the early diagnosis and staging of endometriosis ( 63 , 64 ). Some study found that Gal-3 was over-expressed in all forms of endometriosis ( 65 ), it played an important role in the development of endometriosis and might be a target for endometriosis treatment ( 66 ).…”

A Clinical Diagnostic Value Analysis of Serum CA125, CA199, and HE4 in Women with Early Ovarian Cancer: Systematic Review and Meta-Analysis

“…In the female reproductive system, ovarian cancer has become one of the three common malignant tumors, and about 85%-90% of ovarian malignant tumors are epithelial ovarian cancer [ 1 ]. In recent years, the incidence of ovarian cancer has shown a gradually increasing trend [ 2 ].…”

Inflammatory Markers in Women with Infertility: A Cross-Sectional Study

“…The severity of 19 PLR and NLR may be employed as possible blood indicators for endometriosis, according to a number of studies. [20][21][22] Patients who have been given the diagnosis of unexplained infertility or premature ovarian failure also display an imbalanced adaptive immune system and continue to experience chronic inflammation. 23 This generally agrees with what we discovered.…”