The inflammatory reaction has been proven to be a key factor in the pathogenesis of uterine leiomyoma. The platelet-lymphocyte ratio (PLR) and the neutrophil-lymphocyte ratio (NLR) are inexpensive and reliable inflammatory biomarkers. However, evidence of the relationship between PLR and NLR in patients with uterine leiomyoma is limited. This study aimed to explore the relationship between PLR and NLR in patients with incident uterine leiomyoma. This cross-sectional study included 763 patients with uterine leiomyoma who were first diagnosed in our hospital between January 2016 and December 2016. Patient characteristics were collected for univariate analysis, smooth curve fitting, and multivariate piecewise linear regression. Overall, 722 patients with an average age of 40.16 ± 5.99 years were included. The average PLR was 161.22 ± 65.33. Univariate analysis revealed a significant positive correlation between PLR and NLR ( P < 0.0001 ). In addition, the non-linear relationship between the PLR and NLR was tested using smooth curve fitting after adjusting for potential confounding factors. The multivariate piecewise linear regression model showed that there was a significant positive correlation between PLR and NLR in both PLR <226.45 (β 0.01, 95% CI: 0.01, 0.01; P < 0.0001 ) and >226.45 (β 0.00, 95% CI: 0.00, 0.00; P = 0.0026 ). In conclusion, PLR and NLR are positively correlated in patients with uterine leiomyoma. This result clarifies the promoting role of inflammation in the occurrence of uterine leiomyoma.
IntroductionObesity is a risk factor for the development of uterine leiomyoma (UL), and the inflammatory response plays a key role in the pathogenesis of UL. Our objective was to assess whether there was an independent relationship between inflammatory markers and triglycerides (TG) in patients with UL.Methods1,477 UL participants who were hospitalized at the Jining Medical University between January 2016 and December 2022 were included in this cross-sectional study. The independent and dependent variables measured at baseline were inflammatory markers and TG levels, respectively. The covariates were age, body mass index (BMI), UL and menstrual status. Based on the number of fibroids, the study population was divided into Single-group and Multiple-group.ResultsUnivariate and multiple regression analyses and stratified analyses revealed significant positive correlations between neutrophil-lymphocyte ratio and systemic immune inflammation index and TG, and significant negative correlations between monocyte-lymphocyte ratio and TG.ConclusionThe findings show a significant correlation between the inflammatory response and lipid metabolism levels in UL patients. This provides direction for further research into the pathophysiology of UL and also helps to formulate hypotheses for predictive models of UL.
Infertility is highly correlated with inflammation. We sought to evaluate the independent relationships between each inflammatory marker in women with infertility. Patients and Methods: This cross-sectional study included 1028 infertile patients who were hospitalized at Jining Medical University between January 2016 and December 2022. NLR and PLR were the independent and dependent variables measured at baseline, respectively. Age, body mass index (BMI), and menstrual status were covariates. Based on BMI, the study population was split into two groups: Low-BMI and High-BMI. Results: A stratified analysis revealed that the overweight group had significantly higher levels of WBC, platelet count, lymphocyte count, neutrophil count and NLR. Comparing the overweight group to the normal weight group, the levels were noticeably higher in the overweight group. Significantly positive correlations between NLR and PLR were found in both univariate and multiple regression analyses. Conclusion:There was a significant positive correlation between NLR and PLR in infertility patients. These results will help in the search for biomarkers of infertility and in the development of infertility prediction models.
Purpose To investigate whether there is any difference in the safety, feasibility and intraoperative lymph node clearance of the Da Vinci robot-assisted surgery in endometrial cancer lymph node dissection compared to conventional laparoscopic surgery. Methods A retrospective analysis was made on the clinical data of 83 patients with endometrial cancer enrolled in the Affiliated Hospital of Jining Medical University from January 2018 to March 2022. 41 patients received Da Vinci robot-assisted surgery (RAS group) and 42 received conventional laparoscopic surgery (CLS group). To collect and compare the general condition, operation time, intraoperative bleeding, presence of intraoperative injury, postoperative exhaustion time, application of antibiotics, duration of pelvic drainage tube retention, duration of indwelling catheter, whether postoperative pain medication was applied, whether postoperative abdominal distension was present, number of intraoperative lymph nodes cleared and positive, and LNR between the two groups. Results There was a statistically significant difference (P < 0.05) between the two groups in terms of operative time. There was no statistically significant difference (P > 0.05) in terms of intraoperative bleeding, postoperative time to exhaustion, time to apply antibiotics, time to leave a pelvic drain in place, time to leave a catheter in place, length of hospital stay, whether pain medication was applied postoperatively, and whether there was postoperative abdominal distension. When comparing the number of lymph nodes cleared intraoperatively, the number of positives and LNR between the two groups, the differences were statistically significant (P < 0.05). When the surgical approach, number of intraoperatively cleared lymph nodes, maximum diameter of the mass, tissue grading, type of postoperative pathology, myxomatous infiltration, cervical interstitial involvement and vascular infiltration were compared with the number of positive intraoperative cleared lymph nodes and LNR in each of the 83 patients in a univariate analysis, the differences between the number of intraoperative cleared lymph nodes, maximum diameter of the mass, tissue grading, type of postoperative pathology and cervical interstitial involvement were The differences were not statistically significant (P > 0.05), while the differences were statistically significant (P < 0.05) when comparing the surgical approach, tumour myxomatous infiltration and choroidal infiltration. The number of positive intraoperative lymph node dissection (P = 0.0498) and LNR (P = 0.0455) were compared between the two groups after multiple regression analysis of tumour myofibrotic infiltration and choroidal infiltration, and the differences were statistically significant (P < 0.05). Conclusion This may be related to the 360o wrist rotation of the instrument arm of the Da Vinci robot-assisted surgery, which allows for the smooth removal of deep pelvic lymph nodes with clear exposure, thus allowing more lymph nodes to be cleared, but the relationship remains to be investigated.
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