Correlation between inflammatory marker and lipid metabolism in patients with uterine leiomyomas

Abstract

IntroductionObesity is a risk factor for the development of uterine leiomyoma (UL), and the inflammatory response plays a key role in the pathogenesis of UL. Our objective was to assess whether there was an independent relationship between inflammatory markers and triglycerides (TG) in patients with UL.Methods1,477 UL participants who were hospitalized at the Jining Medical University between January 2016 and December 2022 were included in this cross-sectional study. The independent and dependent variables measured at baseline were inflammatory markers and TG levels, respectively. The covariates were age, body mass index (BMI), UL and menstrual status. Based on the number of fibroids, the study population was divided into Single-group and Multiple-group.ResultsUnivariate and multiple regression analyses and stratified analyses revealed significant positive correlations between neutrophil-lymphocyte ratio and systemic immune inflammation index and TG, and significant negative correlations between monocyte-lymphocyte ratio and TG.ConclusionThe findings show a significant correlation between the inflammatory response and lipid metabolism levels in UL patients. This provides direction for further research into the pathophysiology of UL and also helps to formulate hypotheses for predictive models of UL.

Exploring blood lipids-immunity associations following HBV vaccination: evidence from a large cross-sectional study

“…In contrast, Mahemuti et al found a notable positive correlation between SII and hyperlipidemia (Mahemuti et al, 2023). In a separate study involving uterine leiomyoma patients, the neutrophil-lymphocyte ratio and SII exhibited a significant positive correlation with TG, while the monocyte-lymphocyte ratio demonstrated a notable negative correlation with TG (Duan et al, 2023). Discrepancies in these study outcomes may arise from variations in the studied populations and the utilization of different indicators.…”

Obesity Contributes to Transformation of Myometrial Stem-Cell Niche to Leiomyoma via Inducing Oxidative Stress, DNA Damage, Proliferation, and Extracellular Matrix Deposition

“…Adipokines, adipocyte-released signaling molecules, may promote fibroid tumor proliferation via inflammatory pathways that are upregulated in obese patients [ 6 ]. Among patients with fibroids, pro-inflammatory cytokines and the neutrophil–lymphocyte ratio have been shown to correlate positively with triglyceride levels, suggesting that dyslipidemia, known to induce a pro-inflammatory milieu, may contribute to fibroid growth and development [ 7 ]. The local oxidative stress that accompanies the obese state may further drive fibroid growth via genomic oxidation at the MED12 locus, which is fueled by NOX4 and TGF-β3 signaling [ 8 , 9 ].…”