The clinical evaluation and the preparation and standardization of suspensions of a new water-insoluble whole ragweed pollen complex

Antibody Response in Rabbits Following Intranasal and Parenteral Administration of Birch Pollen

“…For some experiments a 2% suspension of pollen disintegrated by freeze-pressing [9] was used. One group of rabbits was injected with an alumprecipitated aqueous-pyridine extract of birch pollen prepared according to F uchs and Strauss [11]. This preparation contained 10 mg dry weight material/ml.…”

Hemagglutination Titer Changes of Pollinosis Patients Treated with Alum-Precipitated Pyridine Ragweed Extract

“…Serologic tests were performed with serum specimens obtained from a relatively large group of patients treated with alum-precipitated ragweed. Sera were obtained for this study from several hundred patients prior to and at several time intervals following injection therapy with alum-precipitated pyridine extracted ragweed pollen (7). Hemagglutinin antibody titers to the whole ragweed extract were determined by standard tanned cell hemagglutinin techniques using sheep erythrocytes coated with an optimum concentration of whole, defatted ragweed pollen extract (3)(4)(5).…”

Clinical Studies of Two New Ragweed Preparations: ‘Purified’ Delta and Allpyral

“…The clinical results obtained with the allpyral preparation were definitely disappointing in view of the presumed advantages of its administration (fewer injections, less reactions and excellent clinical response), as previously reported (2,6,7,8,9). In re viewing our data, possible explanations for our poor therapeutic results were considered.…”

“…As recommended (2,6,7,8,9), the dose was rapidly increased with each injection in order to reach a maximum of 20,000 PNU after 10 to 12 treatments. This schedule was modified if mo derate local or systemic reactions occurred.…”

“…During the past two years, we have used the delta fraction of ragweed (1) and allpyral ragweed extract (2) in the treatment of ragweed pollenosis. Although these two preparations were developed for different reasons, they are included together in this study in order to compare the results of fairly comparable groups of patients who were treated during the same period of time.…”