A number of papers during the past few years, particularly those of Stewart and Rogoff (1), of Marine and Baumann (2), and of Loeb and his coworkers (3), have shown clearly the close relations which exist between the suprarenal glands and the metabolism of salt and water. The recent studies of Loeb are of fundamental interest since they provide for the first time a rational explanation of the mechanism of suprarenal insufficiency, which this author suggests may be due to a primary loss of sodium through the kidney.The results which follow total ablation of the suprarenal glands in the dog have been confirmed by studies on the effects of withdrawal of injections of the cortical hormone from the suprarenalectomized dog which had been previously maintained with healed wounds in a normal state of health and nutrition (4). Following the withdrawal of the hormone injections it has been shown that there is an increased urinary excretion of sodium, chloride, and of water, relative to the intake, which is presently reflected in a fall in the concentration of * We acknowledge the assistance of Dr. Oliver Kamm, of Parke, Davis and Co., who has generously supplied us for the past 4 years with the beef suprarenal glands from which we prepare our cortical extract.This investigation was aided in part by a grant from the Bingham Fund. We wish to acknowledge the assistance of Dr. Mary Buell in supervising the chemical procedures involved in the manufacture of the cortical extract and in the selection and setting up of analytical methods used in the studies herein reported.A preliminary report of portions of this work has been published (Tr. Assn. Am. Physn., 1934, 49, 153).
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