In the preceding papers (1, 2), we have described the phenomena produced by the cessation of injections of suprarenal cortical extract in the suprarenalectomized adult dog, which has been maintained in a normal state of nutrition, with well healed incisions, for a period of several weeks after suprarenalectomy. We have pointed out that death in such an animal, if injections of the hormone are not resumed, is due to a condition of shock produced by loss of body fluid. The observed sequence of events is: hemoconcentration, which becomes more and more marked; progressive loss of body weight; anorexia; lowered body temperature and basal oxygen consumption; muscular weakness; vomiting and diarrhea; and ultimate failure of the circulation, as indicated by diminished blood flow and fall in blood pressure. These symptoms are associated with a progressive rise in blood nonprotein nitrogen (urea) concentration, a drop in plasma chlorides, and, as we have recently shown (1), a fall in plasma total base. The present communication is concerned with an analysis of the factors producing this hemoconcentration and of the train of phenomena which then follows it. 1 1 We wish to acknowledge the assistance of Dr. Mary Buell in organizing the chemical procedures involved in the manufacture of the cortical extract and in the selection and setting up of analytical methods used in the studies herein reported.We are indebted to Miss Margaret Strauss who has made lactic acid, inorganic phosphorus, and calcium estimations on a series of animals before and during insufficiency.

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A case of a virilizing adrenal adenoma in which bilateral Stein-Leventhal ovaries were found is presented. Despite the morphologic similarity, these ovaries did not possess the in vitro potential for increased androgen production demonstrated by polycystic ovaries removed from patients without apparent adrenal disease. These findings lend support to the thesis that, regardless of the organ source, increased androgen production leads to abnormal ovarian function reflected morphologically in follicle maturation arrest.

of 60 mg. over a 6 month period, without effect on the nephropathy. Three of these patients also received testosterone and cortisone to the point at which virilization occurred, with marked clitoral enlargement, with no amelioration of the kidney damage. One of these also had severe lupus myocarditis (Libman-Sacks syndrome), which was not affected by the above treatment. All the other patients are alive and are leading relatively normal lives.