Clinical Studies of Two New Ragweed Preparations: ‘Purified’ Delta and Allpyral

IMMUNOLOGIC CHANGES DURING SPECIFIC TREATMENT OF THE ATOPIC STATE II. The Serum Immunoglobulin Levels in the Hay Fever Hyposensitization Treatment

“…A certain relation was noted between the binding activity and the clinical tolerance of pollen allergen in the next season or in skin tests. Also using indirect haemagglutination method some differences could be observed {Reisman & Arbesman 1965, Spiegelman, Friedman & Ttift 1967and Zavdzal & Stajner 1969 in comparison with the native treatment. DISCUSSION It was shown that there are certain differences not only in the effect of the repeated therapy with aqueous or alum-pyridine allergens, but also in the immunologic response of both groups of patients.…”

“…A similar statement was observed by inhibition of histamine release from sensitive leukocytes after challenging with ragweed allergen by Lichtenstein, Norman & Winkenwerder 1968. Also using indirect haemagglutination method some differences could be observed {Reisman & Arbesman 1965, Spiegelman, Friedman & Ttift 1967and Zavdzal & Stajner 1969 in comparison with the native treatment. Before the last treatment with alum-pyridine allergens the immunoglobulin G levels were slightly higher, but these differences diminished in the course of the fifth hyposensitization.…”

Grass Pollen Allergoid

“…The clinical efficacy of both extracts was dem onstrated by a num ber o f open and double-blind studies, which showed that antigen dose (4-fold) in the allergoid group. these extracts were equally effective com pared to water-based extracts, but had few er side effects [ 1,3,6,10,25,26,[29][30][31].In 1970 Marsh [12] described 'allergoids'. Allergoids are formed by the treat ment of the original m aterial with glutaraldehyde [21,22,23] and form aldehyde [2,12,15], It was shown in addition to the re duction in allergenicity and the same po tency of imm unogenicity that the m olecu lar size of the modified grass extract in creased considerably.…”

Hemagglutination Titer Changes of Pollinosis Patients Treated with Alum-Precipitated Pyridine Ragweed Extract

“…Y.) indicated that the purified ragweed fraction elicited higher hem agglutinin titers, as well as resulted in better clinical responses, than did the alum-precipitate (8). It was reported that only two of 12 patients treated with the alum-pyridine extract had a 'signif icant' increase in hemagglutinin titer to ragweed antigens following treatment.…”

“…In comparison, there was an 'excellent' immunologic response in the majority of the other patients treated with the partially purified ragweed fraction, administered as an aqueous preparation. However, serum specimens from both groups of patients were tested only with tannic acid treated erythrocytes which had been coated with the purified ragweed preparation, and not with whole ragweed extract (8).…”