The changing pattern of adult primary glomerular disease

Hanko, Jennifer; Mullan, Robert; O’Rourke, Declan; McNamee, P; Maxwell, Alexander P.; Courtney, Aisling E.

doi:10.1093/ndt/gfp254

Cited by 117 publications

(131 citation statements)

References 21 publications

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“…2,67,9,20,21 In our study, membranous nephropathy was also the most frequent glomerular disease, corresponding to 15% of the sample, a finding similar to that of a recent survey of the Paulista Registry of Glomerulopathies, whose percentage was 13.1%. 22 In our study, hypertensive nephrosclerosis was the second most common histological pattern, a finding justified by the high prevalence of arterial hypertension in that age group, which can reach up to 50%.…”

Section: Discussionsupporting

confidence: 90%

Achados histopatológicos renais em idosos

Carmo¹,

Kirsztajn²,

Carmo³

et al. 2010

J. Bras. Nefrol.

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Original article GN, 4.4%; IgA nephropathy and lupus nephritis, 2.7% each. Primary GPs predominated (45.2%) as compared with other nephropathies. Conclusion: Nephrotic syndrome was the major indication for kidney biopsy. Regarding the kidney histological diagnoses, glomerular diseases predominated, in particular MN and hypertensive nephrosclerosis, findings compatible with previous studies in the area, but rarely assessed among us. It is clear that the diversity of diagnoses and differentiated treatments justify kidney biopsy for decision making in that group of patients.

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Section: Discussionsupporting

confidence: 90%

Achados histopatológicos renais em idosos

Carmo¹,

Kirsztajn²,

Carmo³

et al. 2010

J. Bras. Nefrol.

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“…It was reported that membranous nephropathy was much less common in the Chinese population than in the white population. [9][10][11][12][13][14] Although both HLA-DQA1 and PLA2R1 are associated with the development of membranous nephropathy in the Chinese population, PLA2R1 gene variance has shown a much stronger association with the development of IMN as well as the production of anti-PLA2R autoantibodies. In this study, we explored other SNPs in HLA-DOB and HLA-DQB2, which showed a relatively strong signal in European GWAS data; however, only HLA-DQA1 was identified as being associated with membranous nephropathy in the Chinese Han population.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11][12][13][14] In this study, we aim to evaluate the association between these risk alleles and the development of IMN in a large Chinese cohort with .2000 participants and to further explore their roles in the generation of anti-PLA2R antibodies and expression of PLA2R in glomeruli.…”

mentioning

confidence: 99%

Interaction between PLA2R1 and HLA-DQA1 Variants Associates with Anti-PLA2R Antibodies and Membranous Nephropathy

Hou

Zhou

et al. 2013

Journal of the American Society of Nephrology

135

129

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Risk alleles at genome loci containing phospholipase A2 receptor 1 (PLA2R1) and HLA-DQA1 closely associate with idiopathic membranous nephropathy (IMN) in the European population, but it is unknown whether a similar association exists in the Chinese population and whether high-risk alleles promote the development of anti-PLA2R antibodies. Here, we genotyped 2132 Chinese individuals, including 1112 patients with IMN and 1020 healthy controls, for three single nucleotide polymorphisms (SNPs) within PLA2R1 and three SNPs within HLA genes. We also selected 71 patients, with varying genotypes, to assess for circulating anti-PLA2R antibody and for PLA2R expression in glomeruli. Three SNPs within PLA2R1 and one SNP within HLA-DQA1 strongly associated with IMN, and we noted gene-gene interactions involving these SNPs. Furthermore, these risk alleles strongly associated with the presence of anti-PLA2R antibodies and glomerular PLA2R expression. Among individuals who carried risk alleles for both genes, 73% had anti-PLA2R antibodies and 75% expressed PLA2R in glomeruli. In contrast, among individuals who carried protective genotypes of both genes, none had anti-PLA2R antibodies and glomerular expression of PLA2R was weak or absent. In conclusion, the interaction between PLA2R1 and HLA-DQA1 risk alleles associates with the development of IMN in the Chinese population. Individuals carrying risk alleles are predisposed to the generation of circulating anti-PLA2R autoantibodies, which may contribute to the development of IMN.

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“…4 Also, literature shows evidence of change in the spectrum of renal diseases with time in many parts of the world during the recent past. 5 Therefore, regional epidemiological studies of GDs are important over a particular period of time as they contribute to a better understanding of the incidence of different histopathologies and helps in adopting different strategies for prevention and treatment. Many developed countries have established national renal biopsy registries to document such variations and changing trends in the disease spectrum.…”

Section: Introductionmentioning

confidence: 99%