Spectrum of glomerular diseases - clinico-pathologic observations from a state run tertiary care centre

Umesha, L; Varma, Shyam S.; Satishkumar, M M; Leelavathi, V; Shreedhar, C G

doi:10.18203/2320-6012.ijrms20150317

Cited by 3 publications

(11 citation statements)

References 15 publications

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“…MCD followed by FSGS was reported as the prevalent primary GD whereas others showed shift towards FSGS, closely followed by MGN and IgAN as the new leaders. [3][4][5][6][7][8][9][10][11] Amongst elderly Indians, MGN was the leading cause of NS. 21 Two studies from southern India reported this change, with IgAN leading the pack, followed by FSGS.…”

Section: Discussionmentioning

confidence: 99%

“…Narsimhan et al 3 Balakrishnan et al 4 Das et al 9 Lingaraju et al 10 Lakshminarayana MGN accounted for 11.9% of primary GD, with 85% presenting as NS, 15% as SbNP and none as early RD. The average daily proteinuria in MGN was 4262.5±1092.3 grams per day.…”

Section: Aggarwal Et Al 11mentioning

confidence: 99%

“…Lucknow and Christian Medical College (CMC), Vellore, etc, and are useful for publication of data about the prevalent glomerular diseases. [3][4][5][6][7][8][9][10][11] India being the seventh largest and the second most populated country in the world, is expected to have regional variations (inter/intra) in prevalent GD. We conducted a clinicopathological study of biopsy proven renal diseases with an aim to determine the prevalent GD in eastern India, and to assess the inter-and intra-regional variations of prevalent GD comparing various studies from the four different geographical zones of India.…”

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confidence: 99%

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Adult glomerular diseases in east zone and zonal prevalence in India: an Omnium Gatherum

Dogra

Shanmugraj

Jana

et al. 2019

Int J Community Med Public Health

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Background: India is a vast country with four geographical zones. Zonal heterogeneity amongst prevalent adult glomerular diseases is expected and has not been analysed in past studies.Methods: We conducted clinico-histological correlation of 290 kidney biopsies for adult glomerular diseases (GD) at tertiary teaching hospital in Eastern India between January 2013 and December 2015 and compared our data with biopsy data from other geographical zones in India to evaluate zonal variability (intra/inter) of adult glomerular diseases.Results: Males dominated all clinical syndromes except subnephrotic proteinuria (SbNP). IgA Nephropathy (IgAN, 41.1%) and Focal Segmental glomerulosclerosis (FSGS, 17.3%) were prevalent primary GD whereas Lupus nephritis (LN, 52.2%) and diabetic nephropathy (DN, 23.9%) were prevalent secondary GD. IgAN (44.4%) and LN (33.2%) dominated SbNP group whereas FSGS (30.2%) and Membranous nephropathy (MGN, 22.3%) dominated nephrotics. Mean eGFR (CKD-EPI) amongst EyRD and RPRF was 39.6±12.9 and 6.2±2.9 ml/min/1.73m2 respectively. In contrast, biopsies from East India showed MCD prevalence, followed by FSGS. Kidney biopsy data from West India showed MCD prevalence whereas Northern India and South India studies showed FSGS and MCD prevalence, but later data showed an IgAN emergence, as in our data.Conclusions: There is considerable heterogeneity in prevalent adult glomerular diseases in different geographical zones (inter and intra) in India. FSGS and MCD were the most prevalent in all zones. Our study showed IgAN prevalence in East Zone, similar to South India. Reason was, increased number of kidney biopsies in EyRD (eGFR 30-60 ml/min) and subnephrotic proteinuria.

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Section: Discussionmentioning

confidence: 99%

Section: Aggarwal Et Al 11mentioning

confidence: 99%

mentioning

confidence: 99%

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Adult glomerular diseases in east zone and zonal prevalence in India: an Omnium Gatherum

Dogra

Shanmugraj

Jana

et al. 2019

Int J Community Med Public Health

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“…nog tkiva dobivenog biopsijom, putem primjene svjetlosne, imunofluorescentne i elektronske mikroskopije, ušlo se u modernu eru nefrologije i patologije ovog područja [6][7][8] . Biopsija bubrega postala je prihvatljivija nakon publiciranih studija Iversona i Bruna 1951. godine i Alwalla 1952. koji su opisali rezultate aspiracijskih biopsija [9][10] .…”

Section: Biopsija Kao Dijagnostička Metodaunclassified

“…Pregled biopsija bubrega može pružiti podatke i epidemiološke dokaze lokalnih trendova i promjena u obrascima bolesti te usmjeriti pažnju na ranije otkrivanje klinički značajnih bolesti bubrega na određenom području 6 . Epidemiolološki podatci bioptički dokazanih bubrežnih bolesti u našoj populaciji su nedostatni.…”

Section: Zaključakunclassified

Glomerular diseases: a review of the literature and of the epidemiology of biopsy proven glomerular diseases diagnosed in KBC Rijeka

et al. 2016

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Sažetak. Glomerularne bolesti mogu biti uzrokovane hemodinamskim promjenama, infekcijom, nepravilnim imunološkim odgovorom, nasljednim metaboličkim poremećajima, djelovanjem toksičnih tvari, a katkada uzrok ostaje skriven. Bazična znanost i translacijska istraživanja u kombinaciji s kliničkim unaprijedili su naše razumijevanje etiopatogeneze ovih bolesti. Nova znanja dovela su do upotpunjavanja i izmjena postojeće klasifikacije glomerulopatija. Poznavanje molekularnih puteva staničnog ciklusa ili otkrivanje novih genetskih oštećenja pridonijela su kreiranju pametnijih terapeutskih pristupa i boljoj kvaliteti života pacijenata s bubrežnim oštećenjem uz odgodu renalne insuficijencije. Cilj preglednog članka je ukratko razmotriti opća načela u patologiji glomerularnih oštećenja i predočiti neka od novijih istraživanja podocitopatija; membranske glomerulopatije (MG); ANCA vaskulitisa; membranoproliferativnog glomerulonefritisa (GN) i C3 glomerulopatije te ulogu komplementa u oštećenju glomerularnih struktura. Također se ukazuje na vrijednost biopsije bubrega koja uz dijagnostičku i prognostičku ostaje nezaobilazna epidemiološka te istraživačka metoda.

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Morphological Spectrum of Glomerulonephritis in Medical Renal Biopsies: A Single-Center Study

Rafique¹,

Sadaf²,

Batool³

et al. 2022

Cureus

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BackgroundGlomerulonephritis is among the most common and serious non-communicable diseases in the world, and some of them are major causes of chronic kidney disease, which eventually leads to kidney failure. In developing countries, it is the most common cause of end-stage renal disease (ESRD). Chronic kidney disease affects 10-16% of the adult population in Asia, including 21.2% in Pakistan. This study aims to determine the frequency and spectrum of glomerulonephritis at our center. MethodologyThis is a cross-sectional analysis of 81 renal core biopsies obtained between August 2020 and August 2021. The histopathological reports, demographic data, and relevant laboratory investigations, such as blood urea and creatinine levels, were collected. All cases were blindly reviewed by two pathologists with a special interest in medical renal pathology. Data were analyzed using SPSS version 22 (IBM Corp., Armonk, NY, USA). ResultsThe majority of the patients (46.9%) were between the ages of 21 and 40 years. There was a slight male predominance, with 44 (54.3%) of the 81 participants being male. Hematuria was reported in 20 (24.7%) patients, with mean serum urea and creatinine levels of 75 mg/dL and 2.6 mg/dL, respectively. Nephrotic syndrome was the most common indication for a renal biopsy, accounting for 54 (67.7%) of the 81 cases. Chronic glomerulonephritis is classified into two categories, namely, primary and secondary glomerulonephritis. Focal segmental glomerulosclerosis (FSGS), the leading cause of primary glomerulonephritis, was found in 25 (30.9%) 81 patients. Furthermore, lupus nephritis (9.9%) and advanced glomerulonephritis (9.9%) were found in equal proportions among secondary glomerulonephritis. ConclusionsAccording to our study, nephrotic syndrome was the most common indication for medical renal biopsy, with FSGS being the most common primary glomerulonephritis. Lupus nephritis and advanced glomerulonephritis were the most common secondary glomerulonephritis diagnoses.

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Spectrum of glomerular diseases - clinico-pathologic observations from a state run tertiary care centre

Cited by 3 publications

References 15 publications

Adult glomerular diseases in east zone and zonal prevalence in India: an Omnium Gatherum

Adult glomerular diseases in east zone and zonal prevalence in India: an Omnium Gatherum

Glomerular diseases: a review of the literature and of the epidemiology of biopsy proven glomerular diseases diagnosed in KBC Rijeka

Morphological Spectrum of Glomerulonephritis in Medical Renal Biopsies: A Single-Center Study

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