The challenge of antioxidants to free radicals in periodontitis

Pendyala, Gowri; Thomas, Biju; N, Suchetha Kumari

doi:10.4103/0972-124x.44100

Cited by 49 publications

(42 citation statements)

References 14 publications

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“…This outcome may be interpreted as RA having a negative impact on GCF TAS values. The serum TAS value in the C group was higher than that of the CP group, which corroborates the findings of Pendyala et al 43 who reported lower serum antioxidant values in patients with CP compared to healthy controls. Interestingly, there was no significant difference between the C and RA groups in serum TAS values.…”

Section: Discussionsupporting

confidence: 90%

The Effects of Chronic Periodontitis and Rheumatoid Arthritis on Serum and Gingival Crevicular Fluid Total Antioxidant/Oxidant Status and Oxidative Stress Index

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et al. 2012

Journal of Periodontology

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Background: Chronic periodontitis (CP) and rheumatoid arthritis (RA) appear to share many pathologic features. Oxygen metabolism has an important role in the pathogenesis of both CP and RA. The aim of this study is to evaluate the relationship between these two chronic inflammatory diseases with regard to antioxidant and oxidant status. Methods: A total of 80 participants were divided into four groups of 20 each: group RA–CP (patients with RA and CP), group RA (periodontally healthy patients with RA), group CP (systemically healthy patients with CP), and group C (periodontally and systemically healthy volunteers) were included in the study. After assessment of periodontal measurements, gingival crevicular fluid (GCF) samples were taken at one incisor, premolar, and molar tooth and stored with serum samples at −80°C for the antioxidant/oxidant assay. Results: Although all clinical measurements in groups RA–CP and CP were statistically higher compared to those of C and RA groups (P <0.001), there were no differences between CP and RA–CP groups (P >0.05). GCF total oxidant status (TOS) values of CP and RA–CP groups were higher than those of the RA group (P <0.05). GCF oxidative stress index (OSI) values of the RA–CP group were higher than those of the RA group (P <0.05). There were no differences among the groups in terms of serum TOS and OSI values (P >0.05). Conclusions: Local OSI values in groups with patients with CP were higher, whereas systemic OSI values showed no difference among the groups. The presence of RA seems not to affect local and systemic OSI values in patients with CP.

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Section: Discussionsupporting

confidence: 90%

The Effects of Chronic Periodontitis and Rheumatoid Arthritis on Serum and Gingival Crevicular Fluid Total Antioxidant/Oxidant Status and Oxidative Stress Index

Esen

Alkan

Kırnap

et al. 2012

Journal of Periodontology

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“…Smokers are almost four times more likely to have severe periodontitis than non-smokers (12). However, the exact mechanism by which smoking exerts its deleterious effects on periodontium remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Periodontitis

2012

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“…This reactive oxygen species generation may be responsible for the bone resorption, degradation of connective tissue and increase in the matrix metalloproteinase activity. [8] The polymorphonuclear leukocytes are the initial and the predominant defense cells produced during the host response to bacterial pathogens. The periodontopathogens along with their products induce the generation of free radicals.…”

Section: Resultsmentioning

confidence: 99%