Malondialdehyde Levels in Patients With Chronic Periodontitis

Gupta, Madhur; Chari, Suresh; Kolte, Abhay; Chandankhede, Manju

doi:10.14260/jemds/841

Cited by 3 publications

(5 citation statements)

References 6 publications

(4 reference statements)

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“…However, Wei et al [ 26 ] reported insignificant MDA level differences between periodontitis and healthy controls in salivary and serum samples. The remaining studies of the present SR found significantly higher serum or plasma MDA in periodontitis than in healthy controls [ 27 – 30 , 32 , 34 , 40 , 43 , 46 , 49 , 51 , 54 , 56 ]. The serum samples displayed an overall standardized mean difference MDA value of 3.146 nmol/l (95% CI: 1.449–4.844) when the periodontitis group was compared with the healthy control group.…”

Section: Discussionmentioning

confidence: 63%

Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis

Mohideen

Chandrasekar

Ramsridhar

et al. 2023

International Journal of Dentistry

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Objective. The present systematic review and meta-analysis aimed to assess the oxidative stress-mediated lipid peroxidation end product malondialdehyde (MDA) in periodontitis using the available literature. Materials and Methods. An electronic literature search was performed for the published articles from 2000 to 2022 in PubMed (MeSH), Science Direct, Wiley Online library, and cross-reference using specific keywords. Results. The literature search identified 1,166 articles. After analyzing the abstracts of the obtained articles, the articles were excluded for the following reasons: duplicate studies (n = 395) and not relevant to the research question (n = 726). The remaining 45 articles were chosen for full-text evaluation. Finally, the present qualitative synthesis selected 34 articles that met the inclusion criteria for evaluation and removed the articles which did not meet the required criteria (n = 11). Out of these, 16 articles had coherent data for quantitative synthesis. The meta-analysis used the standardized mean differences method at a 95% confidence interval by random-effects model. The periodontitis group displayed significantly higher MDA levels ( P < 0.001 ) in gingival crevicular fluid, saliva, and serum samples of the studies analyzed than the healthy control. Conclusion. The analyzed studies showed significantly higher MDA levels in various biological samples of patients with periodontitis, supporting the role of elevated oxidative stress and consequent lipid peroxidation in periodontitis.

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Section: Discussionmentioning

confidence: 63%

Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis

Mohideen

Chandrasekar

Ramsridhar

et al. 2023

International Journal of Dentistry

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“…Gupta M, et al also found similar trends in MDA in patients with chronic periodontitis. [33] Significantly increased levels of GGT were found in patients with periodontitis as compared to controls. Though GGT is routinely used as a marker for liver functions, results of many studies in the recent times have touted GGT as a very good indicator of oxidative stress.…”

Section: Discussionmentioning

confidence: 93%

Is Periodontitis Associated with Decreased Glomerular Filtration Rate, with Oxidative Stress as an Important Link?

Sreeram¹

2013

IOSR-JDMS

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“…The lipid profile findings of the mentioned study 33 periodontitis. 34 However, as per the BMI calculations in the present study, we did not observe a substantial difference between the study participants belonging to the overweight and obese categories.…”

Section: Bmi Levels (Kg/m 2 ) Males Femalesmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 95%

“…In a case–control study by Gupta et al 33 significant positive correlations were found when total cholesterol and triglycerides were compared with homocysteine in patients of periodontitis with CVD and those with CVD alone as compared to healthy controls. The lipid profile findings of the mentioned study 33 are similar to those of the present clinical trial. On the calculation of percentage reduction in biomarker values 6 months post‐therapy a highly significant reduction was observed which may be attributed to the fact that the NSPT results in a significant decrease in local inflammatory load and tissue destruction factors.…”

Section: Discussionmentioning

confidence: 95%

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Assessment and correlation of the influence of non‐surgical periodontal therapy on serum lipid profile and cytokines in patients with stage III periodontitis

Kolte

Bawankar

et al. 2022

Int J Dental Hygiene

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Background Interleukins are the markers of inflammation and the lipid profile reveals the likelihood of arising cardiovascular disease (CVD). The present study aimed to assess and correlate the influence of non‐surgical periodontal therapy (NSPT) on serum lipid profile and Interleukin‐6 (IL‐6) and Interleukin‐8 (IL‐8) in patients with Stage III periodontitis. Methods Sixty patients with the age range of 35–60 years with Stage III periodontitis were included by evaluating for periodontal parameters such as Probing pocket depth (PPD) and clinical attachment levels (CAL). NSPT was performed at baseline, 3 and 6 months. Biochemical parameters like serum lipid parameters of total cholesterol (TC), triglycerides (TG), low‐density lipopolysaccharide (LDL), high‐density lipopolysaccharide (HDL), and IL‐6 and IL‐8 serum levels were assessed at baseline and 6 months' post‐NSPT. Results The results indicated a significant reduction (p < 0.0001) in the PPD (2.75 ± 0.41), CAL (3.23 ± 0.56), lipid profile, and serum cytokine levels 6 months' post‐NSPT as compared to baseline. A highly significant (p < 0.0001) percentage reduction was observed in the IL‐6 (35.3%), IL‐8 (41.6%), TC (7.5%), TG (1.78%), LDL (6.2%), and HDL (−21.8%) clinical and biochemical parameters at 6 months' recall post‐NSPT. Conclusion Non‐surgical periodontal therapy caused a significant reduction in the levels of serum pro‐inflammatory cytokines IL‐6 and IL‐8 as well as the lipid biomarkers TC, TG, LDL, and increase values of HDL. These findings imply a considerable reduction in the risk of developing CVD in patients with Stage III periodontitis.

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Malondialdehyde Levels in Patients With Chronic Periodontitis

Cited by 3 publications

References 6 publications

Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis

Assessment of Oxidative Stress by the Estimation of Lipid Peroxidation Marker Malondialdehyde (MDA) in Patients with Chronic Periodontitis: A Systematic Review and Meta-Analysis

Is Periodontitis Associated with Decreased Glomerular Filtration Rate, with Oxidative Stress as an Important Link?

Assessment and correlation of the influence of non‐surgical periodontal therapy on serum lipid profile and cytokines in patients with stage III periodontitis

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