Oxidative Stress in Periodontitis

Dhotre, Pradnya Shree; Suryakar, Adinath N.; Bhogade, R. B.

doi:10.29333/ejgm/82469

Cited by 21 publications

(28 citation statements)

References 12 publications

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“…In a study by Epperlein et al [ 10 ], it was suggested that one of the main pathways to damage caused by the gas phase of cigarette smoke was through the NO and hydrogen peroxide interaction giving rise to an active molecule (which may be singlet oxygen) that can initiate lipid peroxidation, and red blood cell glutathione is one of the chief sources of protection against this damage. Another study by Dhotre et al [ 20 ] showed a significant increase in serum lipid peroxide and NO with a corresponding decrease in serum superoxide dismutase, glutathione peroxidase, and total antioxidant capacity in periodontitis patients. Further, it was noted that the oxidant levels were significantly higher and antioxidants were significantly lower in smoker patients than nonsmoker patients.…”

Section: Discussionmentioning

confidence: 99%

Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis

Wadhwa

Bey

Hasija

et al. 2013

J Periodontal Implant Sci

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PurposeCigarette smoking is a major risk factor in periodontal diseases. The pathogenesis of periodontal diseases may be affected by alterations of the inflammatory response by smoke. Nitric oxide (NO) is a gaseous, colorless, highly reactive, short-lived free radical with a pivotal role in the regulation of various physiological and pathological mechanisms in the body. It is important in host defense and homeostasis, on the one hand, whereas, on the other hand, it modulates the inflammatory response in periodontitis, leading to harmful effects. The aim of this study was to assess the levels of NO in both the serum and saliva of smokers and nonsmokers having chronic periodontitis and to compare them with periodontally healthy controls.MethodsSixty subjects participated in the study and were divided into three groups: group I, healthy nonsmoking subjects; group II, nonsmoking patients with chronic periodontitis; group III, smoking patients with chronic periodontitis. Each group consisted of twenty subjects. The biochemical estimation of NO in the collected serum and in the saliva was performed using the Griess colorimetric reaction.ResultsThe results showed that the mean value of the salivary and serum NO was greater in group II than in group I, and also greater in group III than in group II.ConclusionsNO appears to play an important and rather complex role in the immuno-inflammatory process and in the remodeling and maintenance of osseous structures. It is therefore logical that modulation of this mediator has potential for the treatment of a number of inflammatory conditions including periodontal disease.

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Section: Discussionmentioning

confidence: 99%

Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis

Wadhwa

Bey

Hasija

et al. 2013

J Periodontal Implant Sci

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“…Periodontitis is a silent disease. It is an inflammatory response caused by groups of specific microorganisms in which the structural support to the tooth is destroyed (1,2) .…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of the Effectiveness of Coenzyme Q10 Gel in Management of Patients with Chronic Periodontitis ( II Inter Group Comparison )

Salih¹

2016

JBCD

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Background: Periodontal pathogens can induce free radicals over-formation and thus may cause collagen and periodontal destruction. Anti-oxidants are used as supplements to counteract the over production of free radicals in periodontal disease, that can reduce of collagen destruction. Coenzyme Q10 serves as an endogenous antioxidant, regenerates other antioxidants, stimulates cell growth, and inhibits cell death. Because it is an antioxidant, coenzyme Q10 has received much research attention associated with periodontal diseases. Perio Q gel may possibly be effective as a topical agent and as an adjunct to scaling& root planing in treatment of gingivitis and chronic periodontitis. Aim of study:Determine the periodontal health status in a follow up study for 6 weeks of a group of patients with chronic periodontitis by measuring clinical periodontal parameters, which included (Plaque index, Gingival index, Bleeding on Probing, Probing Pocket Depth and Relative Attachment Level) and to evaluate the effect of intra pocket application of perio Q gel (coenzyme Q10) alone & as adjunct to scaling,& root planing on the periodontal clinical parameters in the management of patients with chronic periodontitis. Materials and methods: A total of 323 sites with pocket depth (5-8) mm in patients with chronic periodontitis were randomly divided in three groups. The Gel group, 111 sites were treated with intra-pocket application of Perio Q gel alone. In the Combination group, 106 sites were treated with scaling and root planning (SRP) plus intra-pocket application of Perio Q gel, in Scaling and root planing group, 106 sites were treated with scaling and root planing alone. Clinical periodontal parameters such as Plaque index (PI), Gingival index (GI), Bleeding on probing (BOP), Probing pocket depth (PPD), Relative attachment level (RAL) were assessed at first visit, 3weeks and 6weeks. Results: on intra-group analysis, all groups showed highly significant reduction in PI, GI, BOP, PPD and RAL among the three visits .On inter-group analysis, the results showed significant reduction in the clinical parameters PPD and RAL of combination group in comparison to SRP group. Conclusion: The results of the research were encouraging and suggested the possibility to use the gel as a sole agent to support standard treatment procedures in periodontitis. The clinical parameters significantly improved in the phase of periodontal treatment, indicating that CoQ10 opens new treatment options by improving the host response to disease activity.

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“…The markers, which have always been traditionally used and continue to be popular are estimation of malondialdehyde (TBARS assay), total antioxidant capacity or total antioxidant power, nitric oxide, antioxidant enzymes superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), glutathione reductase, Glutathione-S-Transferase, and estimation nonenzymatic markers like Vitamin C, Vitamin E, coenzyme Q, uric acid, bilirubin etc. [ 8 10 11 12 13 14 15 16 ]…”

Section: Introductionmentioning

confidence: 99%

Is gamma-glutamyl transpeptidase a biomarker for oxidative stress in periodontitis?

Sreeram¹,

Suryakar²,

Dani³

2015

J Indian Soc Periodontol

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Context:Periodontal disease and oxidative stress (OS) are part of a vicious cycle with each causing a deleterious effect on the other causing changes in the levels of antioxidants, and enzymes of antioxidant defense. Biomarkers and methods used for measuring OS are very expensive.Aims:To see how gamma-glutamyltransferase (GGT) fares, as a biomarker for OS in periodontits along with other routinely used biomarkers.Design:A cross-sectional study involving 300 people of which 150 were cases and 150 were controls.Setting:Candidates enrolled were patients visiting the OPD of MGV's Dental College and Hospital, Nasik, India between January 2011 and December 2012.Materials and Methods:Serum samples of patients with periodontitis, and controls were analyzed for malondialdehyde, superoxide dismutase (SOD), glutathione peroxidase (GPx), uric acid, and GGT.Statistical Analysis Used:Analysis was performed using Student's t test. P <0.05 were considered to be significant.Results:Malondialdehyde values were found to be significantly higher cases, while SOD, GPx and uric acid levels were found to be lower than controls. GGT levels were significantly higher in cases as compared to controls.Conclusions:GGT may be used as a cheap, quick, easy and precise marker for measuring OS.

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Oxidative Stress in Periodontitis

Abstract: Periodontitis is one of the most common oral infections induced

Cited by 21 publications

References 12 publications

Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis

Determination of levels of nitric oxide in smoker and nonsmoker patients with chronic periodontitis

An Evaluation of the Effectiveness of Coenzyme Q10 Gel in Management of Patients with Chronic Periodontitis ( II Inter Group Comparison )

Is gamma-glutamyl transpeptidase a biomarker for oxidative stress in periodontitis?

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