The bone-mimicking effect of calcium phosphate on composite chitosan scaffolds in maxillofacial bone tissue engineering

Abstract

This research explored a new trend in biomaterials science. The bone-mimicking effect of calcium phosphate on chitosan composite scaffolds was evaluated. Chitosan with 2% calcium phosphate was found to have suitable bone-mimicking performance for maxillofacial bone tissue engineering.

Research Progress of Shape Memory Polymer and 4D Printing in Biomedical Application

“…[157] (5) Excellent bone induction ability: The unique surface properties of nanomaterials can affect the adsorption and biological activity of some specific proteins, and ultimately affect cell behavior and tissue regeneration. [148][149][150] Studies have shown that nanomaterials are able to interact with certain proteins and thus more effectively promote the healing process of the bone. [158]…”

“…The non‐collagen protein with less content plays a role in inducing bone formation and metabolism. [ 148 ] Porous bone tissue scaffolds with appropriate shape, pore size, porosity, degradability, biocompatibility, mechanical properties, and good cellular response are needed to induce bone regeneration. [ 149 ] However, the highly complex hierarchical structure and composition of bone tissue bring great challenges to the fabrication of biomimetic bone scaffolds.…”

Advanced strategies for constructing interfacial tissues of bone and tendon/ligament

“… 108 , 109 TE, which not only seeks to reconstruct histological structures, but also to restore original biological functions, has been widely applied in orthopedics and there are several strategies for repairing bone defects. 110 – 112 However, the development of enthesis TE is not as advanced and the successful reconstruction of enthesis tissue has not yet been achieved. 3 , 26 , 113 – 115 Studies on the use of TE in enthesis repair involve four strategies, the biological scaffold, cell, growth factor, and biophysical modulation strategies.…”

Improvement of mechanical and antibacterial properties of porous nHA scaffolds by fluorinated graphene oxide

“…2 However, the present scaffolds have shortcomings such as weak mechanical properties and poor antibacterial effect, which lead to the failure of jaw bone regeneration. 3,4 At present, for the preparation of composite scaffolds, researchers are mixing polymeric materials with nanomaterials by 3D printing to fully utilize the advantages of both substances and improve their performance. 5 Hydroxyapatite (HA), the main inorganic component of natural bone, has good bioactivity and osteoinduction, which can be incorporated into new bone, promote osteoblast ossication and differentiation, as well as repair and replace damaged or traumatized bone tissue.…”

“…2 However, the present scaffolds have shortcomings such as weak mechanical properties and poor antibacterial effect, which lead to the failure of jaw bone regeneration. 3,4 At present, for the preparation of composite scaffolds, researchers are mixing polymeric materials with nanomaterials by 3D printing to fully utilize the advantages of both substances and improve their performance. 5…”