Improvement of mechanical and antibacterial properties of porous nHA scaffolds by fluorinated graphene oxide

Abstract

Nano-hydroxyapatite (nHA) is widely used as a bio-scaffold material. In this study, fluorinated graphene oxide (FG) was added to nHA to improve its poor formability, weak mechanical properties and undesirable antimicrobial activity that affect its clinical application.

Development of Poly(methyl methacrylate)/nano-hydroxyapatite (PMMA/nHA) Nanofibers for Tissue Engineering Regeneration Using an Electrospinning Technique

“…Hydroxyapatite is highly hydrophilic [ 57 ], but the water contact angle of PMMA/nHA did not decrease significantly in comparison to pure PMMA. Apart from the possible instrumental effects, one of the possible non-instrumental reasons is related to the low content of nHA particles on the fiber surface [ 58 ].…”

Preparation and Characterization of Carboxymethyl Chitosan/Sodium Alginate Composite Hydrogel Scaffolds Carrying Chlorhexidine and Strontium-Doped Hydroxyapatite

“…The rising incidence of jaw defects due to factors such as inflammation, trauma, tumors, and congenital malformations poses a significant challenge in clinical care, particularly regarding the safe and effective repair and reconstruction of these defects. , Maxillofacial defects profoundly affect not only the normal function and facial aesthetics of patients but also have adverse effects on their physical and mental health. , Bone defects in the oral and maxillofacial areas are often situated in anatomically complex sites that are prone to bacterial infection, producing a high risk of postoperative bacterial infection following the reconstruction of jaw defects. , Staphylococcus aureus is the primary pathogen responsible for these infections . Severe bacterial infections can complicate treating jaw defects, potentially increasing wound size and the likelihood of developing serious osteomyelitis. , Consequently, managing local infections and fostering bone healing are critical aspects of bone repair .…”

“… 1 , 2 Maxillofacial defects profoundly affect not only the normal function and facial aesthetics of patients but also have adverse effects on their physical and mental health. 3 , 4 Bone defects in the oral and maxillofacial areas are often situated in anatomically complex sites that are prone to bacterial infection, producing a high risk of postoperative bacterial infection following the reconstruction of jaw defects. 5 , 6 Staphylococcus aureus is the primary pathogen responsible for these infections.…”