The blood compatibility of chitosan and N‐acylchitosans

Abstract

A segment of silk polyfilament suture [No. 2-0(USP)], ca. 10 cm long, was coated with a thin membrane (2-6 micron) of chitosan, N-acetylchitosan, or N-hexanoylchitosan. The suture was directly inserted into the lumen of dog's peripheral veins. The in vivo blood compatibility of these membranes was macroscopically determined from the blood coagulum formed on the membrane surface at 2 h. An intense thick blood coagulum formed on the chitosan membrane surface and a thin blood coagulum formed on N-acetylchitosan membrane surface, but no blood coagulum formed on N-hexanoylchitosan membrane surface.

Polyelectrolyte complex materials from chitosan and gellan gum

“…Biocompatibility evaluation consists of tissue compatibility (in-vitro and in-vivo) studies and blood compatibility 54,55 . Numerous studies have demonstrated successful…”

Evaluation of Chitosan Gel as Antibiotic and Photosensitizer Delivery

“…This bio-polymer presents interesting characteristics, such as nontoxicity, good biocompatibility (Hirano and Noishiki 1985), bioabsorbility (Muzzarelli et al 1988), and biodegradation, and can be used as a film, gel, or solution (Shin et al 2005). It has been demon-strated that chitosan presents antimicrobial and antifungal activity against many microorganisms, being commercially used as a bioinsecticide and as an agent for fruit conservation (Choi et al 2002).…”

Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

“…Electrospun N-CECS/polyacrylamide (PAAm) blend nanofibers have also been prepared [75]. Hexanoyl chitosan (H-CS) (Figure 2) has good blood compatibility and is anti-thrombogenic [76,77], so it has been used for medical applications. Ultrafine H-CS fibers were successfully prepared by electrospinning of H-CS solutions in chloroform [78].…”