Evaluation of Chitosan Gel as Antibiotic and Photosensitizer Delivery

Fontana, Carla Raquel; Santos, David S. dos; Bosco, Joseane Maria Dias; Spolidório, Denise Madalena Palomari; Marcantonio, Rosemary Adriana Chiérici

doi:10.1080/10717540802007433

Cited by 23 publications

(9 citation statements)

References 33 publications

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“…Results from Ag + release indicate that silver ion releasing was continuous and prolonged with no initial burst release which agrees with other reports where chitosan was used as a vehicle to transport drugs [4][5][6][7], Fig. 2 shows that the maximum concentration was reached after one week with 21.0 70.7 mM (which corresponds to a 70% of the initial silver content).…”

Section: Resultssupporting

confidence: 91%

“…However a vehicle to transport nanoparticles to specific sites with a sustained activity is needed; in this field, the use of hydrogels in transporting drugs has showed excellent results and one of the substances used to prepare these hydrogels is chitosan [4][5][6][7]. Chitosan is a cationic aminopolysaccharide obtained by the alkaline deacetylation of chitin, it presents several characteristics such as bioadhesivity, biodegradablility, biocompatibility, safety, non-toxicity and it promotes drug absorption.…”

Section: Introductionmentioning

confidence: 99%

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Bactericide efficiency of a combination of chitosan gel with silver nanoparticles

et al. 2013

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Bactericide efficiency of a combination of chitosan gel with silver nanoparticles

et al. 2013

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“…5–16 nm were also detected. These shifts are attributed to small alterations of porphyrin molecular environment due to its interaction with chitosan [28,67].…”

Section: Resultsmentioning

confidence: 99%

New Materials Based on Cationic Porphyrins Conjugated to Chitosan or Titanium Dioxide: Synthesis, Characterization and Antimicrobial Efficacy

Castro

Moura

Figueira

et al. 2019

IJMS

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The post-functionalization of 5,10,15-tris(1-methylpyridinium-4-yl)-20-(pentafluorophenyl)porphyrin tri-iodide, known as a highly efficient photosensitizer (PS) for antimicrobial photodynamic therapy (aPDT), in the presence of 3- or 4-mercaptobenzoic acid, afforded two new tricationic porphyrins with adequate carboxylic pending groups to be immobilized on chitosan or titanium oxide. The structural characterization of the newly obtained materials confirmed the success of the porphyrin immobilization on the solid supports. The photophysical properties and the antimicrobial photodynamic efficacy of the non-immobilized porphyrins and of the new conjugates were evaluated. The results showed that the position of the carboxyl group in the mercapto units or the absence of these substituents in the porphyrin core could modulate the action of the photosensitizer towards the bioluminescent Gram-negative Escherichia coli bacterium. The antimicrobial activity was also influenced by the interaction between the photosensitizer and the type of support (chitosan or titanium dioxide). The new cationic porphyrins and some of the materials were shown to be very stable in PBS and effective in the photoinactivation of E. coli bacterium. The physicochemical properties of TiO2 allowed the interaction of the PS with its surface, increasing the absorption profile of TiO2, which enables the use of visible light, inactivating the bacteria more efficiently than the corresponding PS immobilized on chitosan.

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“…Inhibition zone (11 mm) around chitosan gel was measured after 24 and 48 hours of incubation. 19 Periodontitis is a chronic inflammatory, polymicrobial disease that leads to the destruction of the supporting tissues of teeth and if left untreated, leads to tooth loss. Periodontal pockets are populated by various periodontal pathogens.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Efficacy of 1% Chitosan Gel against Periodontal Pathogens: An In Vitro Study

Prakash¹,

Vandana²,

Sarkar³

2021

CODS Journal of Dentistry

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Aim and objective: The purpose of this study was to evaluate the effects of 1% (w/v) chitosan gel as an active agent, on periodontopathogens, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and Tannerella forsythia. Materials and methods: One percent chitosan gel was tested for its antimicrobial activity against four periodontopathogens, P. gingivalis, P. intermedia, F. nucleatum, and T. forsythia by using a disk diffusion test. Results: The effectiveness of chitosan gel can be measured using its zone of inhibition. Chitosan gel showed the maximum zone of inhibition against F. nucleatum. It also produced a wide ring of no bacterial growth where P. gingivalis, P. intermedia, and T. forsythia were inoculated. Conclusion:In this study, it has been demonstrated that chitosan gel is effective against the periopathogens tested, thereby highlighting its potential to be used in the treatment of chronic periodontitis. Clinical significance: Chitosan gel shows promise in vitro, by producing a wide zone of no bacterial growth. Therefore, it can be used in the treatment of chronic periodontitis, clinically.

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Evaluation of Chitosan Gel as Antibiotic and Photosensitizer Delivery

Cited by 23 publications

References 33 publications

Bactericide efficiency of a combination of chitosan gel with silver nanoparticles

Bactericide efficiency of a combination of chitosan gel with silver nanoparticles

New Materials Based on Cationic Porphyrins Conjugated to Chitosan or Titanium Dioxide: Synthesis, Characterization and Antimicrobial Efficacy

Antimicrobial Efficacy of 1% Chitosan Gel against Periodontal Pathogens: An In Vitro Study

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