Preparations, properties and applications of chitosan based nanofibers fabricated by electrospinning

Abstract

Chitosan is soluble in most acids. The protonation of the amino groups on the chitosan backbone inhibits the electrospinnability of pure chitosan. Recently, electrospinning of nanofibers based on chitosan has been widely researched and numerous nanofibers containing chitosan have been prepared by decreasing the number of the free amino groups of chitosan as the nanofibiers have enormous possibilities for better utilization in various areas. This article reviews the preparations and properties of the nanofibers which were electrospun from pure chitosan, blends of chitosan and synthetic polymers, blends of chitosan and protein, chitosan derivatives, as well as blends of chitosan and inorganic nanoparticles, respectively. The applications of the nanofibers containing chitosan such as enzyme immobilization, filtration, wound dressing, tissue engineering, drug delivery and catalysis are also summarized in detail

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

“…especially favourable in the field of pharmaceutical application [7][8][9][10][11][12][13][14][15][16][17][18]. Although the electrospinning (ES) is fast developing with appearance of tri-axial, coaxial, side-by-side and their combination processes [19][20][21][22] the most common and facile ES equipment is the single needle apparatus [23,24].…”

Nanofibrous solid dosage form of living bacteria prepared by electrospinning

“…oped in the textile industry [5][6][7][8], but in the recent years, applications have been published also in various biomedical fields such as wound dressing [9], wound healing [10], sterile filtration [11], tissue engineering [12,13] and drug delivery [14][15][16][17][18][19]. In former studies bioactive ingredients such as proteins and DNA have been embedded successfully in nanofibers mainly for tissue engineering purposes, while living prokaryotic cells were encapsulated by this technique mainly for industrial application in bioreactors utilizing their metabolic activity [20][21][22].…”

A review on electrospun bio-based polymers for water treatment

“…Chitin, the mucopolysaccharides that is made up of ß-(1-4)-N-acetyl-D-glucosamine units linked by 1-4 glycosidic bonds, acts as mechanical strength and supporting structure in crustaceans, insects, etc. (Figure 11) [51,166,167]. Chitin with desirable properties such as good biocompatibility, biodegradability and ubiquitous availability has been used in various fields such as cosmetic, biomedical and in food additives [165].…”

“…In these studies the solubility of chitin was enhanced by Co 60 gamma ray irradiation. Chitin nanofibres with diameters ranging between 50 nm and several microns were electrospun in 1.1.1.3.3.3-hexaflouro-2-propanol (HFIP), with the diameters depending on the electrospinning technique parameters such as concentration [167][168][169]. Min et al [168] irradiated chitin (200 kGy) and obtain an average molecular weight of 91 000 to enhance its dissolution in HFIP.…”