Nanofibrous solid dosage form of living bacteria prepared by electrospinning

Electrospun Solid Dispersions of Maraviroc for Rapid Intravaginal Preexposure Prophylaxis of HIV

“…It remains to be seen if maraviroc can serve as an effective microbicide in humans, either intravaginally or rectally. Previous work on electrospun microbicides has demonstrated the ability to load and release other APIs, including acyclovir (anti-HSV-2), tenofovir (anti-HIV/HSV-2), glycerol monolaurate (antisperm, antimicrobial, anti-inflammatory), and even whole live lactobacilli (antibacterial vaginosis) (8,9,41). We expect that fibers will be capable of delivering a full range of APIs for not only anti-HIV microbicides but also for treatment and prevention of bacterial, fungal, and viral infections.…”

High speed electrospinning for scaled-up production of amorphous solid dispersion of itraconazole

“…One of the most promising nanotechnology-based approaches is electrostatic spinning, which is a remarkably simple and continuous way for producing nanofibers (Lukas et al, 2009). Such nanofibers proved to be valuable in the fields of filtration , composites , textiles, catalysts , medicine anti-counterfeiting (Huang et al, 2010) and medical researches (wound dressing (Rosic et al, 2013), wound healing (Macri et al, 2012;Pelipenko et al, 2013), topical therapy (Huang et al, 2012a(Huang et al, ,b, 2014Nagy et al, 2014) and tissue engineering Driscoll et al, 2013;Nagy et al, 2013)). Electrospinning technology has recently attracted an increased academic and industrial attention because it is an effective way to prepare nanofibrous drug formulations with an enhanced dissolution (Verreck et al, 2003;Brewster et al, 2004;Nagy et al, 2010,c;Yu et al, 2013a,b,c,c;Vrbata et al, 2013;Wagner et al, 2011;Balogh et al, 2014;Li et al, 2013b;Williams et al, 2012;Yan et al, 2014) by combining a number of strategies and approaches.…”

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

“…especially favourable in the field of pharmaceutical application [7][8][9][10][11][12][13][14][15][16][17][18]. Although the electrospinning (ES) is fast developing with appearance of tri-axial, coaxial, side-by-side and their combination processes [19][20][21][22] the most common and facile ES equipment is the single needle apparatus [23,24].…”