High speed electrospinning for scaled-up production of amorphous solid dispersion of itraconazole

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

“…collection, milling and feeding of the fibres The scaled-up electrospinning experiments were performed using a high speed electrostatic spinning setup (Quick2000 Ltd, Tiszavasvári, Hungary) consisting of a round-shaped, stainless steel spinneret connected to a high speed motor [33]. The polymer solution was fed with a peristaltic pump with a flow rate of 200 mL/h.…”

“…However, the productivity of SNES does not satisfy the pharmaceutical requirements thus scaling-up of the technology is essential. In recent years, many methods have been created for this purpose such as needleless electrospinning [25][26][27][28], multineedle electrospinning [29], alternating current electrospinning [30][31][32], and high-speed electrospinning (HSES) [33]. The latter one, where electrostatic and centrifugal forces are combined, may be a highly suitable technology in the pharmaceutical industry for mass production of fibrous drug delivery systems.…”

Nanofibers Fabricated Using Triaxial Electrospinning as Zero Order Drug Delivery Systems

“…Large-scale production of electrospun nanofibers from a single-fluid has been proved to be eminently possible, and industrial systems allowing this now exist. [16][17][18] However, the creation of complicated nanostructures from templates at the macro-scale in a "top-down" manner (i.e., using the structural characteristics of the spinneret to produce nanostructures with analogous features), has yet to be fully explored. 19 The creation of core-sheath nanostructures using a concentric spinneret has been widely reported, but there is a deficit of knowledge regarding other more complex structure types.…”

AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

“…Although various modifications have been published in respect to the ES setup related mostly to the spinneret (e.g., needleless (Molnár and Nagy, 2016), side-by-side or multiaxial electrospinning (Illangakoon et al, 2015;Yang et al, 2016;Yu et al, 2015)), the challenge of increasing the productivity of ES could not have been addressed considering the high output of other fiber formation techniques such as melt blowing (Balogh et al, 2015b). Recent efforts for scaling up of ES combine the electrostatic field with another fiber formation force such as centrifugal force at low (Lomov and Molnár, 2015) and high (Nagy et al, 2015) frequencies, or a blow of air (Balogh et al, 2015c). However, as Pokorny and his coworkers have pointed out, replacing the static direct current (DC) high voltage source generally used for ES to a dynamic alternating current (AC) high voltage also results in a significant increase in productivity (Pokorny et al, 2014).…”