AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

Balogh, Attila; Farkas, Balázs; Verreck, Geert; Mensch, J.; Borbás, Enikő; Nagy, Brigitta; Marosi, György; Nagy, Zsombor Kristóf

doi:10.1016/j.ijpharm.2016.03.024

Cited by 47 publications

(30 citation statements)

References 43 publications

(39 reference statements)

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“…Another strategy for reducing the droplet formation was to add high molecular weight polyethylene oxide (PEO) in low concentration to the PVA solution. PEO is a really good fiber forming polymer, thus it can help the fiber formation of various blends [36,37]. PEO can interact with the PVA molecules by competing with water molecules and combined with the larger molecule size results in an increase of the entanglement.…”

Section: Role Of Peomentioning

confidence: 99%

Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals

Hirsch¹,

Vass²,

Démuth³

et al. 2019

Express Polym. Lett.

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The application of biopharmaceuticals for oral administration is a topic of great interest in the pharmaceutical industry due to the inherent advantages of oral delivery [1]. Biopharmaceutical formulations are more stable in the solid state than in liquid form; in addition, it has many advantages like storage at ambient temperature, longer shelf-life, easier product shipping and the possibility of controlled drug delivery [2]. Currently, the pharmaceutical industry is typically applying freeze drying and spray drying processes in order to obtain solid biopharmaceuticals, however, both technologies have disadvantages [3,4]. Freeze drying is a time-consuming batch technology, has high energy consumption, and the freezing can cause degradation of the biomolecules. On the contrary, spray drying can be operated continuously, is more economical, but can induce inactivation of heat-sensitive molecules, due to the high drying temperature. Electrospinning (ES), which is originally a fiber drawing technology, can be a promising alternative for continuous drying technologies, providing Abstract. Electrospinning is a promising drying technology providing a rapid and gentle drying at ambient temperature, thus electrospinning of polyvinyl alcohol aqueous solutions was investigated for the solid formulation of biopharmaceuticals. The commonly used single-needle electrospinning does not have adequate productivity to satisfy the industrial requirements, therefore our aim was to study the scale-up of the technology by using high-speed electrospinning. High molecular weight polyethylene oxide as a secondary polymer was applied to enhance the fiber formation of polyvinyl alcohol. While polyvinyl alcohol-polyethylene oxide formulations resulted in adequate fiber formation it was not possible to process them further as the friability of the fibers was too low. In order to increase the friability, the effect of adding various sugars (mannitol, glucose, lactose, saccharose, and trehalose) was investigated. The results showed that mannitol was the best friability enhancing excipient because of its crystallinity and low moisture content in the fibrous sample. In contrast, glucose, lactose, saccharose, and trehalose were amorphous with higher moisture content and fibers containing these were grindable only after post-drying.

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Section: Role Of Peomentioning

confidence: 99%

Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals

Hirsch¹,

Vass²,

Démuth³

et al. 2019

Express Polym. Lett.

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“…HPMC is an highly appreciated amorphous-state stabilizing carrier polymer in nanofibers [34]. PEO is known to greatly improve the spinability of HPMC even at small concentrations (<0.1%) [35], and is an easily electrospinnable polymer, widely applied as a co-spinning agent [36]. Although the preliminary studies showed that βG, in combination with HPMC and PEO, could be successfully electrospun from an aqueous solution, applying EtOH as a (co-)solvent made the [38], and explains the different viscosities of two HPMCderivatives tested.…”

Section: The Polymer Solutions and Viscosity Characteristicsmentioning

confidence: 99%

Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice

Grip

Engstad

Skjæveland

et al. 2018

European Journal of Pharmaceutical Sciences

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The increased prevalence of chronic wounds requires novel treatment options. The aim of this study was to develop a beta-glucan (βG)-loaded nanofiber wound dressing. Nanofibers were prepared using the needle-free Nanospider™ technology, an electrospinning method which enables the production of nanofibers at an industrial scale. The βG was selected as active ingredient based on its confirmed wound healing potential in both animals and humans. Hydroxypropyl methylcellulose (HPMC) and polyethylene oxide (PEO) were included as copolymers. Rheological profiles of spinning solutions containing HPMC, PEO, βG, ethanol and water, were optimized. The nanofiber formation was confirmed by Field Emission Scanning Electron Microscopy (FE-SEM), and both nanofibers with (βG-nanofibers) or without βG (NoβG-nanofibers) were evaluated by their swelling index and FT-IR spectroscopy. The formulations, active ingredient and excipients were tested for their possible in vitro toxicity in keratinocytes. Finally, the wound healing potential of the nanofibers was tested in externally induced excisional wounds in male diabetic db/db mice. Three different doses of βG-nanofibers and the βG-free, NoβG-nanofibers, were evaluated for their in vivo wound healing efficacy. All nanofiber-treatments provided improved wound healing as compared to the negative control (water). All βG-nanofiber treated groups exhibited significantly improved wound healing as compared to the NoβG-nanofiber treated group, indicating the potential of βG-nanofibers as wound dressing.

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“…However, the productivity of SNES does not satisfy the pharmaceutical requirements thus scaling-up of the technology is essential. In recent years, many methods have been created for this purpose such as needleless electrospinning [25][26][27][28], multineedle electrospinning [29], alternating current electrospinning [30][31][32], and high-speed electrospinning (HSES) [33]. The latter one, where electrostatic and centrifugal forces are combined, may be a highly suitable technology in the pharmaceutical industry for mass production of fibrous drug delivery systems.…”

mentioning

confidence: 99%

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

Szabó

Démuth

Nagy

et al. 2018

Express Polym. Lett.

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AC and DC electrospinning of hydroxypropylmethylcellulose with polyethylene oxides as secondary polymer for improved drug dissolution

Cited by 47 publications

References 43 publications

Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals

Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals

Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

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