The biochemical function of Mg2+ in insulin secretion, insulin signal transduction and insulin resistance

Günther, Theodor

doi:10.1684/mrh.2009.0195

Cited by 76 publications

(68 citation statements)

References 108 publications

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“…An increase of catecholamines reduces the peripheral sensitivity to insulin [33,34] and the secretion of this hormone[35]. Chronic plasmatic cortisol elevation has been associated with insulin resistance, independently of obesity[36] through a mechanism that would impair β-pancreatic function and peripheral tissue insulin sensitivity[37].…”

Section: Discussionmentioning

confidence: 99%

The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: Analysis of a health population survey in Chile, 2010

et al. 2017

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AimTo estimate the impact of tobacco use, sedentary lifestyle, obesity and alcohol consumption on type 2 diabetes mellitus (T2DM) prevalence in the Chilean population.MethodsThe study-included 5,293 subjects with fasting glycaemia levels from the nationwide cross-sectional health survey in 2010, commissioned by the Ministry of Health, Chile. Crude and Adjusted Odds Ratio to T2DM and its corresponding 95% confidence interval were estimated through logistic regressions. Attributable fractions and population attributable fractions were estimated.ResultsT2DM prevalence was 9.5%. Sedentary lifestyles and obesity were significant risk factors for T2DM. 52,4% of T2DM could be avoided if these individuals were not obese, and at a population level, 23% of T2DM could be preventable if obesity did not exist. A 64% of T2DM is explained by sedentariness, and if people would become active, a 62,2% of the cases of diabetes could be avoided.InterpretationAbout 79% of T2DM cases in Chile could be prevented with cost-effective strategies focused on preventing sedentary lifestyle and obesity. It’s therefore urgent to implement evidence-based public health polices, aimed to decrease the prevalence of T2DM, by controlling its risk factors and consequently, reducing the complications from T2DM.

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Section: Discussionmentioning

confidence: 99%

The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: Analysis of a health population survey in Chile, 2010

et al. 2017

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“…A Ca 2+ influx initiates insulin secretion that is competitively inhibited by extracelluar Mg 2+ , which can explain the inverse association of serum magnesium and insulin concentration. After insulin binds to its receptor and tyrosin kinase is activated, the autophosphorylation of the receptor kinase and all protein tyrosin kinases in the insulin signal transduction are dependent on Mg 2+ [23].…”

Section: Discussionmentioning

confidence: 99%

Serum Magnesium Level is Negatively Associated with Fasting Serum Glucose Level in Korean Adults

Song

et al. 2010

Biol Trace Elem Res

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Several studies have observed an inverse association between serum magnesium and fasting glucose levels. However, there have been sparse data on Koreans. The present study was designed to evaluate the association between serum magnesium and fasting serum glucose levels in Korean adults. A total of 949 Korean adults who visited an outpatient at a university hospital were included in this study. We compared mean values of clinical data according to the tertile of serum magnesium level using analysis of covariance. Association between serum magnesium and fasting glucose levels was evaluated using multiple regression analysis. Odds ratio (OR) was calculated to determine the association between hypomagnesemia and abnormal glucose metabolism. Fasting serum glucose levels decreased significantly from the lowest to the highest tertile of serum magnesium level (108.0±1.4, 106.5±2.1, 102.5±1.7 mg/dl, respectively, p=0.015), whereas blood pressure and lipid profile showed no significant associations. Serum magnesium level was negatively associated with fasting serum glucose level (β=-0.114, p=0.001). Participants with hypomagnesemia had significantly higher OR for abnormal glucose metabolism compared to those with normomagnesaemia (OR=2.28, 95%CI 1.29-4.02). There was a negative association between serum magnesium and fasting glucose levels in Korean adults. In addition, hypomagnesemia was associated with abnormal glucose metabolism.

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“…MgD promotes hypertriglyceridemia, in which numerous, easily-oxidized lipoproteins enter the blood stream [79] and the activity of lipoprotein lipase is down-regulated [80]. Additionally, MgD contributes to insulin resistance and the overproduction of contra-insulin hormones (epinephrine and cortisol) [81, 82]. The key factors implicated in hyperlipidaemia are: the activation of lipolysis in fat tissue, the excessive release of free fatty acids, the stimulation of lipogenesis in the liver followed by the hyperproduction of triglyceride-rich atherogenic lipoproteins and the inhibition of HDL synthesis [34, 83-85].…”

Section: Mechanisms Of Oxidative Stress Caused By Magnesium Deficimentioning

confidence: 99%

Magnesium deficiency and oxidative stress: an update

Желтова¹,

Kharitonova²,

Iezhitsa³

et al. 2016

BioMed

154

102

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Magnesium deficiency (MgD) has been shown to impact numerous biological processes at the cellular and molecular levels. In the present review, we discuss the relationship between MgD and oxidative stress (OS). MgD is accompanied by increased levels of OS markers such as lipid, protein and DNA oxidative modification products. Additionally, a relationship was detected between MgD and a weakened antioxidant defence. Different mechanisms associated with MgD are involved in the development and maintenance of OS. These mechanisms include systemic reactions such as inflammation and endothelial dysfunction, as well as changes at the cellular level, such as mitochondrial dysfunction and excessive fatty acid production.

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The biochemical function of Mg2+ in insulin secretion, insulin signal transduction and insulin resistance

Cited by 76 publications

References 108 publications

The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: Analysis of a health population survey in Chile, 2010

The population impact of obesity, sedentary lifestyle, and tobacco and alcohol consumption on the prevalence of type 2 diabetes: Analysis of a health population survey in Chile, 2010

Serum Magnesium Level is Negatively Associated with Fasting Serum Glucose Level in Korean Adults

Magnesium deficiency and oxidative stress: an update

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