Serum Magnesium Level is Negatively Associated with Fasting Serum Glucose Level in Korean Adults

Song, Chan Hee; Song, In Kwon; Ju, Sang Yhun; Ock, Sun Myeong

doi:10.1007/s12011-010-8889-5

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…We have also observed an association between glucose and Mg, which confirms the results of other studies [32, 33]. In this study, we observed following supplementation that there were increased concentrations of Mg associated with decreased levels of glucose in the serum of the GTE group.…”

Section: Discussionsupporting

confidence: 92%

Effects of Green Tea Supplementation on Elements, Total Antioxidants, Lipids, and Glucose Values in the Serum of Obese Patients

Suliburska

Bogdański

Szulińska

et al. 2012

Biol Trace Elem Res

160

170

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The consumption of green tea has been associated with cardiovascular and metabolic diseases. There have been some studies on the influence of green tea on the mineral status of obese subjects, but they have not yielded conclusive results. The aim of the present study is to examine the effects of green tea extract on the mineral, body mass, lipid profile, glucose, and antioxidant status of obese patients. A randomized, double-blind, placebo-controlled study was conducted. Forty-six obese patients were randomly assigned to receive either 379 mg of green tea extract, or a placebo, daily for 3 months. At baseline, and after 3 months of treatment, the anthropometric parameters, blood pressure, and total antioxidant status were assessed, as were the levels of plasma lipids, glucose, calcium, magnesium, iron, zinc, and copper. We found that 3 months of green tea extract supplementation resulted in decreases in body mass index, waist circumference, and levels of total cholesterol, low-density cholesterol, and triglyceride. Increases in total antioxidant level and in zinc concentration in serum were also observed. Glucose and iron levels were lower in the green tea extract group than in the control, although HDL-cholesterol and magnesium were higher in the green tea extract group than in the placebo group. At baseline, a positive correlation was found between calcium and body mass index, as was a negative correlation between copper and triglycerides. After 3 months, a positive correlation between iron and body mass index and between magnesium and HDL-cholesterol, as well as a negative correlation between magnesium and glucose, were observed. The present findings demonstrate that green tea influences the body's mineral status. Moreover, the results of this study confirm the beneficial effects of green tea extract supplementation on body mass index, lipid profile, and total antioxidant status in patients with obesity.

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Section: Discussionsupporting

confidence: 92%

Effects of Green Tea Supplementation on Elements, Total Antioxidants, Lipids, and Glucose Values in the Serum of Obese Patients

Suliburska

Bogdański

Szulińska

et al. 2012

Biol Trace Elem Res

160

170

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“…Therefore, in most normal adults, serum magnesium ranges from 0.70 to 1.10 mM/L. In Korea, there was a few report about magnesium status of normal population or pregnant women, Song et al reported that the magnesium levels of these subjects including type 2 diabetes patients are 0.85±0.07 mM/L, respectively (18). However, the National Academy of Science and the Institute of Medicine have reported that an estimated 50%-85% of the US population has subclinical or severe magnesium deficiency (19).…”

Section: Discussionmentioning

confidence: 99%

Serum Magnesium Level Is Associated with Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus: The Korea National Diabetes Program Study

et al. 2014

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Gestational diabetes mellitus (GDM) is a strong predictor of postpartum prediabetes and transition to overt type 2 diabetes (T2DM). Although many reports indicate that low magnesium is correlated with deteriorated glucose tolerance, the association between postpartum serum magnesium level and the risk for T2DM in women with a history of GDM has not been evaluated. We analyzed postpartum serum magnesium levels and development of prediabetes and T2DM in women with prior GDM according to American Diabetes Association (ADA) criteria using the Korean National Diabetes Program (KNDP) GDM cohort. During a mean follow-up of 15.6±2.0 months after screening, 116 women were divided into three groups according to glucose tolerance status. Ultimately, eight patients (6.9%) were diagnosed with T2DM, 59 patients (50.9%) with prediabetes, and 49 patients (42.2%) with normal glucose tolerance (NGT) after follow-up. The T2DM group had the lowest serum magnesium level (0.65 [0.63-0.68] mM/L) in the postpartum period, but there was no significant difference between the prediabetes group (0.70 [0.65-0.70] mM/L) and the NGT group (0.70 [0.65-0.70] mM/L) (P=0.073) Multiple logistic regression analysis showed that postpartum HOMA-IR was a significant predictor of both prediabetes and T2DM. Moreover, we found that postpartum serum magnesium level was also a possible predictor for T2DM development. Serum magnesium level in the postpartum period may be a possible predictor for T2DM development in women with a history of GDM.

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“…Mg may play a key role in the regulation of carbohydrate and lipid metabolism (44,45). Severe magnesium deficiency can promote lipogenesis (5,29,41).…”

Section: Discussionmentioning

confidence: 99%

Mg supplementation attenuates ritonavir-induced hyperlipidemia, oxidative stress, and cardiac dysfunction in rats

Mak

Kramer

Chen

et al. 2013

American Journal of Physiology-Regulatory, Integrative and Comp

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Mak IT, Kramer JH, Chen X, Chmielinska JJ, Spurney CF, Weglicki WB. Mg supplementation attenuates ritonavir-induced hyperlipidemia, oxidative stress, and cardiac dysfunction in rats. Am J Physiol Regul Integr Comp Physiol 305: R1102-R1111, 2013. First published September 18, 2013 doi:10.1152/ajpregu.00268.2013.-Use of protease inhibitors (PI) in HIV patients is associated with hyperlipidemia and increased risk of coronary heart disease. Chronic systemic and cardiac effects of ritonavir (RTV), a universal PI booster, and Mg supplementation were examined. RTV was administered (75 mg·kg Ϫ1 ·day Ϫ1 po) to LewisϫBrown-Norway hybrid (LBNF1) rats for up to 8 wk; significant increases in plasma triglyceride and cholesterol occurred from 8 days to 8 wk. At 5 wk, the expression of selected hepatic genes (CYP7A1, CITED2, G6PC, and ME-1), which are key to lipid catabolism/synthesis, were altered toward lipogenesis. Dietary Mg supplementation (six-fold higher) completely reversed the altered expression of these genes and attenuated both hypertriglyceridemia and hypercholesterolemia. Neutrophils isolated from the RTV-treated rats displayed a three-fold higher basal and a twofold higher stimulated superoxide production; plasma isoprostane and red blood cell (RBC) GSSG levels were elevated twoto three-fold. All oxidative indices were normalized by Mg supplementation. After 5 wk, RTV caused significant decreases in cardiac left ventricular (LV) shortening fraction and LV ejection fraction; mitral valve early/late atrial ventricular filling (E/A) ratio was reduced accompanied by LV posterior wall thinning. Immunohistochemical staining revealed significant white blood cell (WBC) infiltration (5 wk) and prominent fibrosis (8 wk) in the RTV hearts. Mg supplementation attenuated RTV-induced declines in systolic and diastolic (improved mitral valve E/A ratio) function (Ͼ70%), lessened LV posterior wall thinning (by 75%), and substantially decreased the pathological markers. The known clinical hyperlipidemia effects of RTV can be mimicked in the LBNF1 rats; in association, systemic oxidative stress and progressive cardiac dysfunction occurred. Remarkably, Mg supplementation alone suppressed RTV-mediated hyperlipidemia, oxidative stress, and cardiac dysfunction.HIV-1 protease inhibitor ritonavir; hepatic metabolic gene regulation; hyperlipidemia; oxidative stress; cardiac dysfunction; dietary Mg supplementation ACCORDING TO A RECENT REPORT (47), there are 34 million people worldwide infected with HIV-1, and of these, 1.3 million are in the United States (7). Nucleoside/nucleotide analogs, with Zidovudine (AZT) as the prototype compound, were first introduced in the late 1980s and continue to play a significant role in HIV therapy (13). With the introduction of protein inhibitors (PIs) in the mid 1990s, HIV-1 replication in the patients was shown to be dramatically reduced, and currently, to the extent that HIV-1 infection has become a more manageable disease (20,23). However, along with the chronic use of PIs, significant metabolic si...

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Serum Magnesium Level is Negatively Associated with Fasting Serum Glucose Level in Korean Adults

Cited by 8 publications

References 21 publications

Effects of Green Tea Supplementation on Elements, Total Antioxidants, Lipids, and Glucose Values in the Serum of Obese Patients

Effects of Green Tea Supplementation on Elements, Total Antioxidants, Lipids, and Glucose Values in the Serum of Obese Patients

Serum Magnesium Level Is Associated with Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus: The Korea National Diabetes Program Study

Mg supplementation attenuates ritonavir-induced hyperlipidemia, oxidative stress, and cardiac dysfunction in rats

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