Summary: The main literature concerning the physiology and biochemistry as well as the pathophysiology and pathobiochemistry of magnesium is reviewed, including:Distribution and physico-chemical state of magnesium in the extracellular and intracellular fluid as well as in the subcellular organelles (membranes, mitochondria, microsomes, ribosomes).Intestinal resorption, transport across membranes and excretion by the kidney.Hormonal regulation of magnesium distribution and its clinical disturbances.Biochemical mechanism and the clinical effects of hypo-and hypermagnesemia.
Magnesium-Stoffwechsel: Eine ÜbersichtZusammenfassung: Die wichtigsten Arbeiten über die Physiologie und Biochemie sowie Pathophysiologie und Pathobiochemie des Magnesiums werden dargestellt.Die Darstellung bezieht sich im wesentlichen auf: Die Verteilung und den physikalisch-chemischen Zustand des Mg in der extrazellulären und intrazellulären Flüssigkeit und in den Zellorgänellen (Membranen, Mitochondrien, Mikrosomen, Ribosomen). Die Resorption im Darm, Transport durch Membranen und die Ausscheidung durch die Niere.Die hormonale Regulation der Mg-Verteilung und ihre klinischen Störungen. Biochemische Mechanismen und klinische Erscheinungen bei Hypo-und Hypermagnesiämie.
Mg2+ efflux from Mg2+‐loaded rat thymocytes was stimulated by 0.1 mM dibutyryl cAMP (db cAMP). The activation of Mg2+ efflux by db cAMP was more expressed at lower Mg2+‐loading, cAMP induced only a very small increase in the concentration of intracellular free Mg2+ which cannot explain the activation of Na+/Mg2+ antiport. From these results it was concluded that cAMP increases the affinity of the Na+/Mg2+ antiporter for intracellular Mg2+, probably by phosphorylation.
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