The Association Between Thalassemia Major and Periodontal Health

Abstract

TM may have a role in the underlying systemic hematologic condition and potentially affect gingival inflammation via dysregulation of lymphocytes and increased activation of osteoclasts.

Association of thalassemia major and gingival inflammation: A pilot study

“…In the same study, higher levels of a proliferation-inducing ligand (APRIL), receptor activator of nuclear factor kappa B ligand (RANKL), IL-6, IL-8 were found in the TM group than the systemically healthy counterparts. The present findings suggesting an exacerbation in local inflammatory response in the TM patients are in line with our previous study pointing that TM may have a role in the underlying systemic hematologic condition and potentially affect gingival inflammation via dysregulation of lymphocytes and increased activation of osteoclasts (Akcali et al, 2015).…”

“…Salivary MMP-9/TIMP-1 positively correlated with all clinical periodontal parameters, whereas, salivary MMP-8 correlated with BOP and PI, salivary MMP-9 correlated with PD in the TM group. In a recent study by our group, GCF, serum and salivary levels of B cell activating factor (BAFF), interleukin (IL)-6 and IL-8 in TM patients with gingivitis than the systemically healthy patients with gingivitis (Akcali et al, 2015). In the same study, higher levels of a proliferation-inducing ligand (APRIL), receptor activator of nuclear factor kappa B ligand (RANKL), IL-6, IL-8 were found in the TM group than the systemically healthy counterparts.…”

Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major

“…Hemoglobinopathies, mainly thalassemia and SCD, are globally prevalent. Thalassemia refers to a group of congenital and autosomal recessive hemolytic anemias, involving deficiencies in the synthesis of either the alpha or the beta polypeptide chains of hemoglobin [1][2][3].The homozygous form of the disease, which is known as Beta-thalassemia major (BTM), is one of the most frequent monogenic diseases in the Middle East, Asia, and the south pacific region. In Iran, which is located in the global thalassemia ring, about 3 million carriers and 25,000 individuals with BTM are registered [4,6].…”

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

“…These discrepant results might be explained by the age difference of the included participants between the studies. Patients with thalassemia were shown to have increased levels of several inflammatory markers in gingival crevicular fluid and in saliva, such as IL-6, IL-8, matrix metalloproteinase (MMP)-8, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1, compared with a systemically healthy group suggesting an exacerbation of the local immune response in these patients, which could affect the periodontal condition [48,50]. Whether there is a difference in periodontal status between thalassemia and SCD is not clear, though it has been shown that thalassemia patients have more missing teeth than SCD patients [32].…”