Finally, the study gives an insight into the various oral and dento-maxillofacial manifestations of SCD and BTM and also reveals an association that exists between the oral and dento-maxillofacial manifestations and systemic health in these patients, thus stressing the importance of the concise and periodic examination of these individuals to perform appropriate preventive dental and periodontal care, and the facilitation of the management of the disease.

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Oral LP lesions have been reported in about 50-70% of patients with cutaneous lichen planus, but nearly 23% of patients have only oral lesions, and 15-28% of patients have both skin and oral lesions concomitantly (DeRossi et al., 2005;Cheng et al., 2016). In contrast to dermal LP, oral mucosal lesions are refractory to treatment

Background: Transfusion-transmitted cytomegalovirus infection (TT-CMV) is known to cause significant morbidity and mortality in immunosuppressed patients particularly among allograft recipients and infants born with birth weights less than 1.5 kg. Objectives: This is the first report in Iran showing the prevalence of CMV-DNA in whole blood/red cell components to evaluate safety for patients. Patients and Methods: 153 units of whole blood or red cell components [CPDA1 RBC (n = 88), washed RBC (n = 50), whole blood CPDA1 (n = 1), whole blood low volume (n = 1) and leukocytes reduced (n = 13)] were selected for the presence of CMV-DNA from two different hospitals in Gorgan. Detection of CMV-DNA in plasma was performed by nested polymerase chain reaction (Nested PCR) using specific primers selected from highly conserved regions of major capsid protein (MCP) gene of human cytomegalovirus. In addition, CMV-IgM antibody of plasma was analyzed by serological methods. Data was analyzed using SPSS software (version 18). Results: Totally, 2 of 153 (1.3%) whole blood or red cell components had positive results for CMV infection. Both viremia and anti-IgM CMV positivity were 0.65% (1/153), respectively. CMV-DNA was detected in 2/88 CPDA1 RBC, but not in other products. Conclusions: Unscreened whole-blood derivatives can act as a vehicle for transmission of CMV infection, thus, screening for cytomegalovirus infection should be performed at least for special groups of patients.

Patients suffering from hemoglobinopathies may suffer from pathogic dental and orofacial features. This study aimed to assess the prevalence of malocclusion and the need for orthodontic treatment in patients with β-thalassemia major (BTM) and sickle cell disease (SCD). The study was conducted on 311 blood transfusion-dependent patients with BTM or SCD and 400 healthy individuals aged 10 to 16. The types of malocclusion were evaluated based on Angle’s classification and Dewey’s modification, and their oral habits were recorded using a questionnaire. The need for orthodontic treatment was assessed through the Dental Health Component of the Index of Orthodontic Treatment Need (IOTN), and the data were compared with normal participants. The Index of Orthodontic Treatment Need-Dental Health Component (IOTN-DHC) assessment showed that patients had a higher prevalence of objective need for treatment (IOTN grades 4 and 5) compared to healthy children. The prevalence of class II malocclusion was significantly higher in patients. Patients showed significantly less Angle’s Class I malocclusion compared to normal participants. Oral habits were presented in 61%, 64.15% and 62.4% of normal participants, BTM and SCD patients, respectively. The higher prevalence of Angle’s class II malocclusion and higher percentage of IOTN grade 4 and 5 among BTM and SCD patients reveal the importance of early orthodontic assessment and intervention in children with BMT and SDC.