Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major

Kalbassi, Salmeh; Younesi, Mohammad Reza; Asgary, Vahid

doi:10.1080/10245332.2017.1404219

Cited by 17 publications

(37 citation statements)

References 20 publications

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“…According to our search strategy, we comprehensively retrieved and identified 78 and 41 articles from PubMed and Embase, respectively. We reviewed 13 full-text articles; however, the investigators of one of the 4 studies did not provide available data [11,16,29,30]. Although we sent emails to contact the corresponding authors of these studies, we received no reply.…”

Section: Analysis Of Subgroupsmentioning

confidence: 99%

“…Ultimately, we included a total of 9 studies within 8 publications featuring a comparison group included in the systematic review and in the meta-analysis [9,15,16,22,23,32-34]. Table 1 summarizes the main characteristics of the included studies [9,15,16,22,23,[32][33][34]. The publication year ranged from 2002 to 2018.…”

Section: Analysis Of Subgroupsmentioning

confidence: 99%

“…Common oral manifestations have been described in SCD patients, including lower salivary flow [9,10], increased levels of biofilm [11,12], hypomineralization of the enamel [13] and dental caries [6,14]. In addition, frequent admission, drug treatments, and diminished oral hygiene are high-risk factors for caries, which contribute to more dental caries in SCD patients [15][16][17]. Dental caries can destroy hard tissues of the teeth and may lead to pulpitis and periapical periodontitis, which can even become a source of infection in sickle cell crisis due to an insufficient blood supply [18,19].…”

Section: Introductionmentioning

confidence: 99%

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Association between sickle cell disease and dental caries: a systematic review and meta-analysis

Hui

et al. 2020

Hematology

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Objectives: Although dental caries has been widely reported in individuals with sickle cell disease (SCD), there is still controversial in the literature regarding the association between SCD and dental caries. The aim of this systematic review was to investigate whether individuals with SCD have more dental caries than individuals with non-SCD. Methods: PubMed and Embase databases were searched for eligible studies. The parameters of the permanent decayed, missing and filled teeth (DMFT) index and the permanent decayed, missing and filled surface (DMFS) index were considered as outcome measures. The overall meta-analyses of the DMFT and DMFS index and various subgroup analyses (caries components, age, and genotypes) of DMFT index were performed to calculate the weighted mean differences (WMD) between patients with SCD and non-SCD individuals. Results: A total of 9 studies covering 1478 individuals were included in this meta-analysis. The results of overall meta-analyses indicated that the scores of the DMFT and DMFS index were not significantly different between patients with SCD and non-SCD participants. The results of subgroup analyses by caries components, age, and genotypes showed no significant difference in most items. The result of the missing teeth was significantly lower in patients with SCD than in non-SCD individuals (WMD, −0.14; 95% confidence interval [CI], −0.25 to −0.03; P = 0.01). Discussion and Conclusions: The results revealed that compared with non-SCD individuals, patients with SCD did not suffer from worse dental caries. Considering the limitations, further well-designed studies are necessary to reveal the association between SCD and dental caries. KEYWORDS Sickle cell disease; sickle cell anemia; dental caries; oral health; sickle hemoglobin S; decayed, missing and filled teeth; decayed, missing and filled surface; meta-analysis

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Section: Analysis Of Subgroupsmentioning

confidence: 99%

Section: Analysis Of Subgroupsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between sickle cell disease and dental caries: a systematic review and meta-analysis

Hui

et al. 2020

Hematology

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“…Furthermore, patients with thalassemia major are found to have significantly higher DMFT in comparison to those with thalassemia intermedia [31]. Of note, DMFT index has been reported to be higher in thalassemia patients than in SCD [29,32]. It has been suggested that this increased caries experience in thalassemia might be due to lower concentrations of IgA in saliva, which could allow increased microbial proliferation [23].…”

Section: Anemia and Oral Healthmentioning

confidence: 99%

“…Patients with thalassemia were shown to have increased levels of several inflammatory markers in gingival crevicular fluid and in saliva, such as IL-6, IL-8, matrix metalloproteinase (MMP)-8, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1, compared with a systemically healthy group suggesting an exacerbation of the local immune response in these patients, which could affect the periodontal condition [48,50]. Whether there is a difference in periodontal status between thalassemia and SCD is not clear, though it has been shown that thalassemia patients have more missing teeth than SCD patients [32].…”

Section: Anemia and Oral Healthmentioning

confidence: 99%

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Boström

Lira-Júnior

2019

Curr Oral Health Rep

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Purpose of Review This review aims to summarize the literature on inherited hemoglobin and coagulation disorders, focusing on sickle cell disease (SCD), thalassemia, hemophilia, and von Willebrand disease (vWD), and their impact on oral health. Clinical dental management of patients with these conditions is also reviewed. Recent Findings There is no evident association between caries and SCD. Despite limited available studies, there may be a possible association between caries and thalassemia, which could relate to salivary changes in immunoglobulin A and Streptococcus mutans reported in these patients. Controversial results on the caries experience of hemophilia and vWD patients are found in the literature, which are likely to reflect differences in the provided preventive dental care of these patients rather than a biological association. Current evidence does not support any association between periodontal disease and SCD. The literature on periodontal disease and thalassemia shows controversial results although some evidence suggests differences in the gingival inflammation of thalassemia patients with increased levels of inflammatory cytokines and matrix metalloproteinases, deserving further investigation. The available literature does not provide evidence of an increased risk for gingival bleeding or periodontal disease in patients with hemophilia or vWD. Dental management of these patients requires appropriate measures to prevent infection and excessive bleeding. The use of local hemostatic may often be sufficient; however, in severe bleeding disorders, systemic hemostatic or replacement therapy may be required, and procedures are recommended to be planned with the patient's hematologist. Summary Maintaining good oral health through preventive dentistry is important for patients with inherited hemoglobin and coagulation disorders as that may prevent the risk of infection and the need for invasive dental treatments that can result in bleeding complications. Keywords Hematologic diseases. Anemia. Blood coagulation disorders. Oral health. Periodontal diseases. Dental caries This article is part of the Topical Collection on Systemic Diseases * Elisabeth A.

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Thalassaemia

2022

A Practical Approach to Special Care in Dentistry

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Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major

Cited by 17 publications

References 20 publications

Association between sickle cell disease and dental caries: a systematic review and meta-analysis

Association between sickle cell disease and dental caries: a systematic review and meta-analysis

Non-Malignant Blood Disorders and Their Impact on Oral Health: an Overview

Thalassaemia

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